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G-protein coupled receptor kinase-2 regulates the migration of chronic lymphocytic leukaemia cells to sphingosine-1 phosphate in vitro and their trafficking in vivo. [PDF]
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[Chronic lymphocytic leukaemia].
Ugeskrift for laeger, 2021Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the world with approximately 450 new cases yearly in Denmark. The disease is highly heterogeneous, and half of the patients will never require treatment. The standard treatment is chemoimmunotherapy, but highly effective targeted therapies are approved for patients with high-risk ...
Caspar, da Cunha-Bang +2 more
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The Lancet, 2018
Important advances in understanding the pathogenesis of chronic lymphocytic leukaemia in the past two decades have led to the development of new prognostic tools and novel targeted therapies that have improved clinical outcome. Chronic lymphocytic leukaemia is the most common type of leukaemia in developed countries, and the median age at diagnosis is ...
Michael, Hallek +2 more
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Important advances in understanding the pathogenesis of chronic lymphocytic leukaemia in the past two decades have led to the development of new prognostic tools and novel targeted therapies that have improved clinical outcome. Chronic lymphocytic leukaemia is the most common type of leukaemia in developed countries, and the median age at diagnosis is ...
Michael, Hallek +2 more
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Critical Reviews in Oncology/Hematology, 2016
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among the adults in the Western World. CLL (and the corresponding nodal entity small lymphocytic lymphoma, SLL) is classified as a lymphoproliferative disorder characterised by the relentless accumulation of mature B-lymphocytes showing a peculiar immunophenotype in the peripheral blood ...
Scarfò, Lydia +2 more
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Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among the adults in the Western World. CLL (and the corresponding nodal entity small lymphocytic lymphoma, SLL) is classified as a lymphoproliferative disorder characterised by the relentless accumulation of mature B-lymphocytes showing a peculiar immunophenotype in the peripheral blood ...
Scarfò, Lydia +2 more
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The Lancet, 2008
Chronic lymphocytic leukaemia is the commonest form of leukaemia in Europe and North America, and mainly, though not exclusively, affects older individuals. It has a very variable course, with survival ranging from months to decades. Major progress has been made in identification of molecular and cellular markers that could predict disease progression ...
Dighiero, G., Hamblin, T.J.
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Chronic lymphocytic leukaemia is the commonest form of leukaemia in Europe and North America, and mainly, though not exclusively, affects older individuals. It has a very variable course, with survival ranging from months to decades. Major progress has been made in identification of molecular and cellular markers that could predict disease progression ...
Dighiero, G., Hamblin, T.J.
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Medicine, 2000
Abstract Chronic lymphocytic leukaemia (CLL) results from neoplastic proliferation of a mature B lymphocyte. It is defined by a persistent lymphocytosis of more than 10 × 10 9 /litre and lymphoid infiltration of the bone marrow of at least 40%. With the use of immunological markers, it is possible to establish the diagnosis of CLL by B cell clonality,
Estella Matutes, Claire Dearden
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Abstract Chronic lymphocytic leukaemia (CLL) results from neoplastic proliferation of a mature B lymphocyte. It is defined by a persistent lymphocytosis of more than 10 × 10 9 /litre and lymphoid infiltration of the bone marrow of at least 40%. With the use of immunological markers, it is possible to establish the diagnosis of CLL by B cell clonality,
Estella Matutes, Claire Dearden
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The Lancet
The last decade has seen remarkable progress in our understanding of disease biology of chronic lymphocytic leukaemia (CLL) and the development of novel targeted therapies. Randomised clinical trials have reported improved progression-free survival and overall survival with targeted therapies compared with chemoimmunotherapy, and thereby the role of ...
Nitin, Jain +2 more
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The last decade has seen remarkable progress in our understanding of disease biology of chronic lymphocytic leukaemia (CLL) and the development of novel targeted therapies. Randomised clinical trials have reported improved progression-free survival and overall survival with targeted therapies compared with chemoimmunotherapy, and thereby the role of ...
Nitin, Jain +2 more
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Chronic lymphocytic leukaemia treatment
Blood Reviews, 1993Advances in the understanding of the natural history and prognosis of chronic lymphocytic leukaemia (CLL) and the introduction of new drugs and strategies have renewed interest in the treatment of this disease. Clinical trials in patients stratified according to risk factors are useful to determine the efficacy of different treatments.
E, Montserrat, C, Rozman
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Lymphocyte Kinetics in Chronic Lymphocytic Leukaemia
British Journal of Haematology, 197051‐Chromium was used to study lymphocyte kinetics in patients with chronic lymphocytic leukaemia. Lymphocytes were found to equilibrate with a pool larger than that accounted for by blood volume and the blood lymphocyte count. Lymphocyte disappearance from the blood stream was exponential and complex, with an initial large rapid component and a smaller
J L, Spivak, S, Perry
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