Results 261 to 270 of about 46,203 (306)

Chronic Lymphocytic Leukaemia with Binucleated Lymphocytes

Leukemia & Lymphoma, 1997
Chronic lymphocytic leukaemia (CLL) is a monoclonal proliferation usually involving B cells and composed of mature lymphoid cells. Distinct morphologic subtypes have been recognized according to lymphocyte size, nuclear:cytoplastic ratio and nucleolus.
I, Amouroux, H, Mossafa, O, Gentilhomme, R, Girot, G, Flandrin, X, Troussard   +5 more
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Chronic lymphocytic leukaemia

Medicine, 2013
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in developed countries. It is a disease of the elderly, usually incurable and characterized by significant clinical and biological heterogeneity. Many patients are diagnosed after the incidental finding of a sustained lymphocytosis, while others present with symptomatic disease requiring ...
Devereux, Stephen, Cuthill, Kirsty
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ZAP70 in chronic lymphocytic leukaemia

The International Journal of Biochemistry & Cell Biology, 2008
The protein tyrosine kinase zeta-chain associated protein kinase (ZAP70), normally expressed in T cells and a subset of B cells, is solely expressed in poor prognosis chronic lymphocytic leukaemia and implicated in enhanced B cell receptor signalling. As a result, the expression of this protein provides an ideal prognostic marker for the disease.
Amin S, Parker A, Mann J
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Chronic lymphocytic leukaemia genetics overview

British Journal of Haematology, 2007
SummaryAlthough the familial aspect of chronic lymphocytic leukaemia (CLL) has been appreciated for decades, it is only with the recent confluence of improved molecular and gene technologies and world‐wide collaborative networks that accelerated progress has become apparent.
Neil, Caporaso, Lynn, Goldin, Christoph, Plass, George, Calin, Gerald, Marti, Steven, Bauer, Elizabeth, Raveche, Mary Lou, McMaster, David, Ng, Ola, Landgren, Susan, Slager   +10 more
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NULL CELL CHRONIC LYMPHOCYTIC LEUKAEMIA

Medical Journal of Australia, 1979
Lymphocytes lacking receptors for sheep erythrocytes and surface immunoglobulin were present in the blood in large numbers at some stage in four cases of chronic lymphocytic leukaemia (which included a mother and son), and formed a substantial proportion of the circulating lymphocytes in other cases.
I J, Forbes, P D, Zalewski, P, Cowled, H, Lander, R E, Sage, B, Dale   +5 more
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Management of Chronic Lymphocytic Leukaemia

Drugs & Aging, 2000
Chronic lymphocytic leukaemia (CLL) is the most common form of adult leukaemia in Western countries. The diagnosis requires mature-appearing lymphocytes in the peripheral blood to >5 x 10(9)/L. The immunophenotype typically includes B cell antigens CD19, CD20 and CD23, low expression of surface immunoglobulin and CD5+, with other T cell antigens absent.
N, Kalil, B D, Cheson
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Fludarabine in chronic lymphocytic leukaemia

Expert Opinion on Pharmacotherapy, 2006
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. Historically, CLL patients have received prednisone- or chlorambucil-containing regimens, resulting in modest responses and a slim chance of long-term survival.
Thomas, Elter, Michael, Hallek, Andreas, Engert   +2 more
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Splenectomy in Chronic Lymphocytic Leukaemia

Scandinavian Journal of Haematology, 1977
In a retrospective study it was endeavoured to evaluate the effects of splenectomy in chronic lymphocytic leukaemia (CLL) characterised by splenomegaly. The material comprises 42 patients subjected to the operation in the course of the past 20 years. In the majority the spleen weighed more than 1000 g.
B E, Christensen, M M, Hansen, A, Videbaek   +2 more
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Chronic lymphocytic leukaemia

2010
Chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL) is the most prevalent lymphoid neoplasm in Europe and North America. The ‘cell of origin’ is a mature B lymphocyte that has a rearranged immunoglobulin gene. CLL cells express modest amounts of surface immunoglobulin, and are characterized by defective apoptosis. The cause of CLL is unknown.
Clive S. Zent, Aaron Polliack
openaire   +1 more source

Transient leukaemia cutis in chronic lymphocytic leukaemia

Clinical and Experimental Dermatology, 1997
Leukaemia cutis arises from cutaneous infiltration by neoplastic leukocytes or their precursors. Recent evidence suggests that this sign does not necessarily herald a poor prognosis. We describe a 72-year-old woman with B-cell chronic lymphatic leukaemia who developed a papular eruption of her breast at the site of a recent herpetic eruption. Histology
S H, Wakelin, E, Young, S, Kelly, M, Turner   +3 more
openaire   +3 more sources