Results 81 to 90 of about 1,936,563 (245)

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Outcomes of dietitian involvement with leukemia patients receiving total parenteral nutrition [PDF]

, 2002
Plan BThere is an increasing need for justification of medical nutrition therapy given by the dietitian. With health care costs escalating rapidly, practitioners need to demonstrate that they can improve patient outcomes.
Mattson, Christine
core  

Társult tumorok előfordulása krónikus lymphoid leukaemiában | Occurrence of associated tumours in chronic lymphocytic leukemia [PDF]

, 2016
Absztrakt Bevezetés: A krónikus lymphoid leukaemia az egyik leggyakoribb hematológiai rosszindulatú kórkép. Célkitűzés: A 2000–2015 között diagnosztizált krónikus lymphoid leukaemiás betegek ...
László Szerafin, Jakó, János, Szerafin, László, Lóránt Varju, János Jakó, Varju, Lóránt   +5 more
core   +1 more source

Myeloid sarcoma presenting as an isolated pancreatic mass in a 3‐year‐old child

JPGN Reports, EarlyView.
Abstract Myeloid sarcoma (MS) is an extramedullary tumor of myeloid precursor cells, frequently associated with acute myeloid leukemia (AML), and rarely occurring in isolation. We present a child with obstructive jaundice secondary to a pancreatic head mass.
Jappmann Kaur Monga, Cara L. Mack, Michelle Saad, Dylan Applin, Maisam Abu‐El‐Haija, David Vitale, Zachary Graff, Gila Ginzburg   +7 more
wiley   +1 more source

Pattern of Occurrence of Leukemia at a Teaching Hospital in Eastern Region of Nepal - A Six Year Study

Journal of Nepal Medical Association, 2009
INTRODUCTION: Pattern of leukemia is known to vary widely throughout the world. The characterization of distribution patterns of different subtypes of leukemia in Nepal needs further study.
Ritu Kulshrestha, SP Sah
doaj   +1 more source

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Ocular Manifestations in Acute and Chronic Leukemia: A Prospective Observational Study from Northwestern Rajasthan

Delhi Journal of Ophthalmology
Aim: The aim is to evaluate the pattern of ocular manifestations in patients with acute and chronic leukemia, both myeloid and lymphoid, admitted to a tertiary care institution in Northwestern Rajasthan. Materials and Methods: A prospective observational
Navdeep Kaur, Khyati Yadav, Shilpi Kochar, Anil Chouhan, Jaishri Murli Manoher   +4 more
doaj   +1 more source

Paraneoplastic leukocytoclastic vasculitis in chronic lymphoid leukemia [PDF]

, 2007
A 50-year-old female who was a known case of chronic lymphoid leukemia (CLL) developed ecchymoses, purpuric spots with papules, some nodules (1-3 mm) and crusts all over the body associated with severe burning and itching along with exaggeration of CLL ...
Yadav, BS, Sharma, SC
core   +4 more sources