Results 1 to 10 of about 90,048 (278)
Mechanisms of Resistance and Implications for Treatment Strategies in Chronic Myeloid Leukaemia. [PDF]
Cancers (Basel), 2022 Simple Summary Chronic myeloid leukaemia (CML) is a type of blood cancer that is currently well-managed with drugs that target cancer-causing proteins. However, a significant proportion of CML patients do not respond to those drug treatments or relapse ...
Poudel G +3 more
europepmc +2 more sources
Treatment of blast phase chronic myeloid leukaemia: A rare and challenging entity. [PDF]
Br J Haematol, 2022 Despite the success of BCR‐ABL‐specific tyrosine kinase inhibitors (TKIs) such as imatinib in chronic phase (CP) chronic myeloid leukaemia (CML), patients with blast phase (BP)‐CML continue to have a dismal outcome with median survival of less than one ...
Copland M.
europepmc +2 more sources
Nature Communications, 2021 In chronic myeloid leukaemia (CML), the drivers of blast crisis and resistance to tyrosine kinase inhibitors are not fully characterised. Here, the authors analyse a cohort of CML samples with genomic technologies and find that at least one driver ...
Yotaro Ochi +34 more
doaj +2 more sources
An update on chronic myeloid leukaemia [PDF]
Clinical Medicine, 2001 The therapy of CML is clearly 'work in progress' Although long-term follow-up data for patients treated with STI571 are not yet available, preliminary results are encouraging. STI571 is likely to be licensed in late 2001/early 2002 and will certainly find a place in the treatment of CML. Current therapeutic considerations are summarised in Fig 2.
G Stark, Stephen G. O’Brien
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A rare case of an elderly male with progression to chronic myeloid leukaemia secondary to chronic lymphocytic leukaemia [PDF]
European Journal of Case Reports in Internal MedicineChronic lymphocytic leukaemia (CLL) is a lymphoproliferative disorder characterised by an accumulation of monoclonal B lymphocytes, with an increased risk of secondary cancers.
Sakditad Saowapa +7 more
doaj +2 more sources
Chronic myeloid leukaemia in Central Africans
East African Medical Journal, 2004 To document the pattern of presenting clinical and haematological features of chronic myeloid leukaemia (CML) in central Africans and evaluate the clinical consequences of treating the disease with chemotherapy.Prospective descriptive analysis of clinical and haematological data.Departments of Haematology of tertiary referral centres and teaching ...
JM Mukiihi +5 more
openalex +6 more sources
Chronic myeloid leukaemia with marked thrombocytosis [PDF]
eJHaem, 2021 Jun Ooi, Tomonori Sato
doaj +4 more sources
Adult type CML in paediatric age group – a case series from tertiary care hospital
Asian Journal of Medical Sciences, 2021 Chronic myeloid leukaemia is a clonal disorder arising from hematopoietic stem cell, affecting all the lineage of haematopoietic stem cells. The average age of affection in chronic myeloid leukaemia is 60 to 65 years and is extremely rare in childhood ...
Sumaiya Irfan +3 more
doaj +1 more source
Clinicohaematological Study of Leukaemias at a Tertiary Care Centre, Vindhya Region of India: A Cross-sectional Study [PDF]
National Journal of Laboratory Medicine, 2023 Introduction: Leukaemia is characterised by widespread proliferation of leucocytes and their precursors in the body tissues and is usually associated with qualitative and quantitative changes in circulating white blood cells.
Lekha Ramchandani +3 more
doaj +1 more source