Socioeconomic cost of AML in Sweden—A population‐based study using multiple nation‐wide registers
eJHaem, 2021 Acute myeloid leukemia (AML) is associated with a high economic and clinical burden. Recently novel therapies have been added to standard treatment regimens. Here, we evaluated the economic impact of AML up until the introduction of these novel therapies.
Emma Hernlund +6 more
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Concurrent Evaluation of the Expression and Methylation of Secreted Frizzled-Related Protein 2 along with Beta-Catenin Expression in Patients with non-M3 Acute Myeloid Leukemia [PDF]
Iranian Journal of Medical Sciences, 2021 Background: Wnt signaling is a critical pathway for the development of acute myeloid leukemia (AML). Some studies have evaluated the expression or methylation of secreted frizzled-related protein 2 (SFRP2) as an antagonist and beta-catenin (β-catenin) as
Fatemeh Mirzaeyan +5 more
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The consequences of cohesin mutations in myeloid malignancies
Frontiers in Molecular Biosciences, 2023 Recurrent somatic mutations in the genes encoding the chromatin-regulatory cohesin complex and its modulators occur in a wide range of human malignancies including a high frequency in myeloid neoplasms. The cohesin complex has a ring-like structure which
Shubhra Ashish Bhattacharya +6 more
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Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease
Frontiers in Immunology, 2023 The liver is a vital metabolic organ that also performs important immune-regulatory functions. In the context of infections, the liver represents a target site for various pathogens, while also having an outstanding capacity to filter the blood from ...
Mohamed Amer Musrati +8 more
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Congenital leukemia cutis in an infant
Indian Journal of Paediatric Dermatology, 2022 Background: The infiltration of neoplastic leukocytes or their progenitors into the epidermis, dermis, or subcutis, resulting in clinically evident cutaneous lesions, is known as leukemia cutis.
Carol Lobo, J P Prathibha
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Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy
Frontiers in Immunology, 2020 Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and ...
Els Lebegge +11 more
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Outcomes of allogeneic stem cell transplantation in acute leukemias – single centre study [PDF]
Documenta Haematologica, 2023 Aim: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is recommended in first complete remission (CR) for adverse and intermediate-risk acute myeloid leukemia (AML) and not recommended for AML patients with favourable disease.
Alexandra Oana ENACHE +7 more
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Purification of Tumor-Associated Macrophages (TAM) and Tumor-Associated Dendritic Cells (TADC)
Bio-Protocol, 2014 Tumors are heterogeneous microenvironments where complex interactions take place between neoplastic cells and infiltrating inflammatory cells, such as tumor-associated macrophages (TAM) and tumor-associated dendritic cells (TADC).
Damya Laoui +4 more
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Systemic Reprogramming of Monocytes in Cancer
Frontiers in Oncology, 2020 Monocytes influence multiple aspects of tumor progression, including antitumor immunity, angiogenesis, and metastasis, primarily by infiltrating tumors, and differentiating into tumor-associated macrophages.
Máté Kiss +7 more
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Cancer Reports, 2023 Background Although Ethiopia has more than 78% of leukemia cases and a significant burden of the disease, the survival of leukemia patients in the country is poorly recognized.
Bargude Balta +2 more
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