Results 31 to 40 of about 586,559 (303)

Tagraxofusp in myeloid malignancies

Hematological Oncology, 2023
Abstract Tagraxofusp (or SL‐401) is a recombinant molecule composed of human interleukin‐3 that binds CD123 on neoplastic cells fused to a truncated diphtheria toxin (DT). Tagraxofusp's most significant success has come from studies involving patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), an aggressive disease ...
Antonella Bruzzese, Enrica Antonia Martino, Caterina Labanca, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Antonino Neri, Annalisa Imovilli, Fortunato Morabito, Ernesto Vigna, Massimo Gentile   +10 more
openaire   +3 more sources

Adoptive Transfer of Monocytes Sorted from Bone Marrow

Bio-Protocol, 2019
Inflammatory Ly6Chi monocytes can give rise to distinct mononuclear myeloid cells in the tumor microenvironment, such as monocytic myeloid-derived suppressor cells (Mo-MDSC), immature macrophages, M2-like tumor-associated macrophages (TAMs), M1-like TAMs
Damya Laoui, Eva Overmeire, Chloé Abels, Jiri Keirsse, Jo Ginderachter   +4 more
doaj   +1 more source

Hematopoietic stem cells produce intermediate lineage adipocyte progenitors that simultaneously express both myeloid and mesenchymal lineage markers in adipose tissue

Adipocyte, 2021
Some adipocytes are produced from bone marrow hematopoietic stem cells. In vitro studies previously indicated that these bone marrow-derived adipocytes (BMDAs) were generated from adipose tissue macrophage (ATM) that lose their hematopoietic markers and ...
Kathleen M. Gavin, Timothy M. Sullivan, Joanne K. Maltzahn, Jeremy T. Rahkola, Alistair S. Acosta, Wendy M. Kohrt, Susan M. Majka, Dwight J. Klemm   +7 more
doaj   +1 more source

High-Yield Human Induced Pluripotent Stem Cell-Derived Monocytes and Macrophages Are Functionally Comparable With Primary Cells

Frontiers in Cell and Developmental Biology, 2021
Macrophages are pivotal effectors of host immunity and regulators of tissue homeostasis. Understanding of human macrophage biology has been hampered by the lack of reliable and scalable models for cellular and genetic studies.
Di Cui, Alexandra Franz, Sophie A. Fillon, Linda Jannetti, Timo Isambert, Katrin Fundel-Clemens, Heinrich J. Huber, Coralie Viollet, Alexander Ghanem, Akira Niwa, Bernd Weigle, Stefan Pflanz, Stefan Pflanz   +12 more
doaj   +1 more source

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells [PDF]

, 2011
Chronic myeloid leukaemia (CML) is maintained by a rare population of tyrosine kinase inhibitor (TKI)-insensitive malignant stem cells. Our long-term aim is to find a BcrAbl-independent drug that can be combined with a TKI to improve overall disease ...
E K Allan, Holyoake, T.L., Jorgensen, H.G., A R Craig, T L Holyoake, Allan, E.K., Craig, A.R., H G Jørgensen   +7 more
core   +1 more source

Acute myelogenous leukemia – current recommendations and approaches in molecular-genetic assessment

Romanian Journal of Internal Medicine, 2022
Acute myelogenous leukemia is a multi-step hematological malignancy, affecting function, growth, proliferation and cell cycle of myeloid precursors.
Yahya Dinnar, Hachmeriyan Mari, Micheva Ilina, Chervenkov Trifon   +3 more
doaj   +1 more source

Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia - a randomised SAL pilot study [PDF]

, 2012
INTRODUCTION: Older patients with acute myeloid leukemia (AML) experience short survival despite intensive chemotherapy. Azacitidine has promising activity in patients with low proliferating AML.
Ulrich Dührsen, Anja Koschmieder (106749), Matthias Stelljes, Christian Thiede (106768), Carsten Müller-Tidow, Nicola Tidow (106758), Noppeney, Richard, Utz Krug, Gerhard Ehninger, Daniela Schwammbach (106754), Steffen Koschmieder, Nicola Tidow, Wolfgang E Berdel, Markus Schaich (106764), Stelljes, Matthias, Matthias Stelljes (106772), Utz Krug (106744), Carsten Müller-Tidow (105305), Krug, Utz, Tidow, Nicola, Bug, Gesine, Schaich, Markus, Björn Steffen, Richard Noppeney (106769), Gerss, Joachim, Christian Thiede, Joachim Gerss, Schwammbach, Daniela, Thomas Büchner, Björn Steffen (106759), Büchner, Thomas, Ulrich Dührsen (106782), Anja Koschmieder, Christoph Röllig, Steffen, Björn, Markus Schaich, Steffen Koschmieder (106779), Thomas Büchner (106775), Hubert Serve, Koschmieder, Steffen, Christian H. Brandts (106762), Ehninger, Gerhard, Brandts, Christian Hubertus, Berdel, Wolfgang E., Joachim Gerss (106757), Gerhard Ehninger (106788), Dührsen, Ulrich, Wolfgang E. Berdel (106792), Richard Noppeney, Gesine Bug (106760), Serve, Hubert, Müller-Tidow, Carsten, Daniela Schwammbach, Christian H Brandts, Hubert Serve (106786), Thiede, Christian, Gesine Bug, Koschmieder, Anja, Röllig, Christoph, Christoph Röllig (106766), Koschmieder Steffen, Ehninger, G. (Gerhard), Schaich, M. (Markus), Tidow Nicola, Gerß, J. (Joachim), Müller-Tidow, C. (Carsten), Steffen Björn, Röllig, C. (Christoph), Thiede Christian, Dührsen, U. (Ulrich), Bug Gesine, Brandts, C.H. (Christian), Stelljes Matthias, Thiede, C. (Christian), Brandts Christian H., Noppeney, R. (Richard), Büchner, T. (Thomas), Schaich Markus, Tidow, N. (Nicola), Schwammbach, D. (Daniela), Röllig Christoph, Steffen, B. (Björn), Koschmieder Anja, Serve, H. (Hubert), Koschmieder, A. (Anja), Noppeney Richard, Bug, G. (Gesine), Krug Utz, Dührsen Ulrich, Stelljes, M. (Matthias), Berdel, W.E. (Wolfgang), Büchner Thomas, Schwammbach Daniela, Serve Hubert, Krug, U. (Utz), Berdel Wolfgang E., Ehninger Gerhard, Koschmieder, S. (Steffen), Gerss Joachim, Müller-Tidow Carsten   +99 more
core   +2 more sources

Effects of Stem Cell Factor on Hypoxia-Inducible Factor 1 Alpha Accumulation in Human Acute Myeloid Leukaemia and LAD2 Mast Cells [PDF]

, 2011
Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signalling through the tyrosine kinase receptor known as Kit or CD117.
Bernhard F. Gibbs, Sumbayev, Vadim V., Yasinska, Inna M., Gibbs, Bernhard F., Vadim V. Sumbayev, Inna M Yasinska, Abraham E. Oniku, Vadim V Sumbayev, Oniku, Abraham E., Bernhard F Gibbs, Abraham E Oniku, Inna M. Yasinska   +11 more
core   +2 more sources

Signaling through CD44 affects cell cycle progression and c-Jun expression in acute myeloid leukemia cells [PDF]

, 2004
We present here the first evidence linking CD44 signaling to c-Jun expression and cell cycle progression in myeloid cell line models. CD44 ligation with the anti-CD44 monoclonal antibodies have been shown to induce differentiation and inhibit the ...
Peer Zada, Abdul Ali
core   +1 more source

Immunophenotypic Aberrancies in Acute Leukemia: A Tertiary Care Centre Experience

Oman Medical Journal, 2021
Objectives: Acute leukemias (AL) are a heterogeneous group of hematological malignancies with the presence of 20% or more blasts in the peripheral blood or bone marrow.
Monika Gupta, Lovekesh Monga, Dimple Mehrotra, Sonia Chhabra, Shivani Singhal, Rajeev Sen   +5 more
doaj   +1 more source