Results 11 to 20 of about 604,501 (260)

A dual origin for Bcr-Abl gene translocation/fusion as dynamics of synergism of the hematopoietic stem cell and hemangioblast in chronic myeloid leukemia [PDF]

, 2015
Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core   +1 more source

Polyphenon E enhances the antitumor immune response in neuroblastoma by inactivating myeloid suppressor cells [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Note: In this manuscript as well as in the original published version of this article the word "Polyphenon" was incorrectly spelled in the title as ...
Chayka, O, Sala, A, Piotrowska, I, Himoudi, N, D'Alicarnasso, M, Cantilena, S, Santilli, G, Morgenstern, DA, Thrasher, AJ, Pearson, K, Anderson, J   +10 more
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Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity [PDF]

, 2015
Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have ...
Sumbayev, Vadim V., Gibbs, Bernhard F, Yasinska, Inna M., Sumbayev, Vadim V, Casely-Hayford, Maxwell A., Gibbs, Bernhard F., Vadim V. Sumbayev, Berger, Steffen M., Maryam Abooali, Prokhorov, Alexandr, Yasinska, Inna M, Abooali, Maryam, Berger, Steffen Michael, Isabel Gonçalves Silva, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Fasler-Kan, Elizaveta, Alexandr Prokhorov, Gonçalves Silva, Isabel, Casely-Hayford, Maxwell A, Maxwell A. Casely-Hayford, Inna M. Yasinska, Steffen M. Berger, Abooali M, Casely-Hayford MA, Berger SM, Yasinska IM, Gibbs BF, Sumbayev VV, Prokhorov A, Gonçalves Silva I, Fasler-Kan E   +31 more
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Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells [PDF]

, 2011
Chronic myeloid leukaemia (CML) is maintained by a rare population of tyrosine kinase inhibitor (TKI)-insensitive malignant stem cells. Our long-term aim is to find a BcrAbl-independent drug that can be combined with a TKI to improve overall disease ...
E K Allan, Holyoake, T.L., Jorgensen, H.G., A R Craig, T L Holyoake, Allan, E.K., Craig, A.R., H G Jørgensen   +7 more
core   +1 more source

Systemic Reprogramming of Monocytes in Cancer

Frontiers in Oncology, 2020
Monocytes influence multiple aspects of tumor progression, including antitumor immunity, angiogenesis, and metastasis, primarily by infiltrating tumors, and differentiating into tumor-associated macrophages.
Máté Kiss, Máté Kiss, Aarushi Audhut Caro, Aarushi Audhut Caro, Geert Raes, Geert Raes, Damya Laoui, Damya Laoui   +7 more
doaj   +1 more source

Survival and predictors of mortality among acute leukemia patients on follow‐up in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A 5‐year retrospective cohort study

Cancer Reports, 2023
Background Although Ethiopia has more than 78% of leukemia cases and a significant burden of the disease, the survival of leukemia patients in the country is poorly recognized.
Bargude Balta, Tigistu Gebreyohannis, Erdaw Tachbele   +2 more
doaj   +1 more source

Philadelphia Chromosome-Positive de Novo AML or Blast Phase CML? Case Report and Short Literature Review [PDF]

Documenta Haematologica, 2023
The BCR::ABL1 translocation and the accompanying Philadelphia chromosome represents the first mutation which defined a disease, chronic myeloid leukemia.
Dan-Sebastian SOARE, Georgiana Elena ENE, Daniela DIACONESCU, Delia SOARE, Cristina ENACHE, Cristina MAMBET, Ion DUMITRU, Madalina CIRNU, Ana Maria VLADAREANU, Eugen RADU, Horia BUMBEA   +10 more
doaj   +1 more source

Molecular Measurable Residual Disease Testing of Blood During AML Cytotoxic Therapy for Early Prediction of Clinical Response

Frontiers in Oncology, 2019
Measurable residual disease (MRD) testing after initial chemotherapy treatment can predict relapse and survival in acute myeloid leukemia (AML). However, it has not been established if repeat molecular or genetic testing during chemotherapy can offer ...
Hong Yuen Wong, Anthony D. Sung, Katherine E. Lindblad, Sheenu Sheela, Gregory W. Roloff, David Rizzieri, Meghali Goswami, Matthew P. Mulé, Nestor R. Ramos, Jingrong Tang, Julie Thompson, Christin B. DeStefano, Kristi Romero, Laura W. Dillon, Dong-Yun Kim, Catherine Lai, Christopher S. Hourigan   +16 more
doaj   +1 more source

Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies

eLife, 2020
Cancer immunotherapy by immune checkpoint blockade has proven its great potential by saving the lives of a proportion of late stage patients with immunogenic tumor types.
Ana Rita Pombo Antunes, Isabelle Scheyltjens, Johnny Duerinck, Bart Neyns, Kiavash Movahedi, Jo A Van Ginderachter   +5 more
doaj   +1 more source

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Nature Communications, 2016
Tissue-resident macrophages are mostly derived from embryonic progenitors. Scott et al. develop a mouse model to specifically deplete Kupffer cells (KC) in vivoand show that monocyte-derived cells can repopulate KC niche and behave similar to their ...
Charlotte L. Scott, Fang Zheng, Patrick De Baetselier, Liesbet Martens, Yvan Saeys, Sofie De Prijck, Saskia Lippens, Chloé Abels, Steve Schoonooghe, Geert Raes, Nick Devoogdt, Bart N. Lambrecht, Alain Beschin, Martin Guilliams   +13 more
doaj   +1 more source