Results 41 to 50 of about 586,559 (303)

Age-related changes of the innate immune system of the palatine tonsil in a healthy cohort

Frontiers in Immunology, 2023
Although tonsillectomy is performed frequently, the role of palatine tonsils in life long immune protection or tolerance is still debated and the consequences of their removal for the immune system are of general interest.
Nico Andreas, Katharina Geißler, Juliane Priese, Orlando Guntinas-Lichius, Thomas Kamradt   +4 more
doaj   +1 more source

Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia [PDF]

, 2009
<b>Background</b>: The majority of acute myeloid leukaemia (AML) patients are over sixty years of age. With current treatment regimens, survival rates amongst these, and also those younger patients who relapse, remain dismal and novel ...
Gunther Ulrich L., Gunther, U., Khanim, F.L., Alessia Lodi, Jim A Murray, Birtwistle Jane, Lodi, A, Chris, M., Gunther, Ulrich L., Khanim, Farhat L., Drayson, Mark T., Khanim Farhat L., Murray, James, Mountford, Joanne C., Murray, J.A., Ulrich L Gunther, Drayson, M., Tiziani, S, Gunther, U.L., Jane Birtwistle, Green Richard M., Farhat L Khanim, Bunce, Christopher, Hayden, R.E., Ride, Jon P., Murray, J., Mountford, J.C., Mark T Drayson, Davies, N., Schrewe, H., Stefano Tiziani, Drayson Mark T., Hayden, Rachel, Viant Mark R., Khanim, Farhat, Murray, Jim A., Davies, Nicholas, Lodi, A., Ride, Jonathan, Chris M Bunce, Gunther, Ulrich, Lodi, Alessia, Viant, Mark R., Tiziani, Stefano, Richard M Green, Viant, Mark; id_orcid, Mountford, JC, Ride, J.P., Joanne C Mountford, Green, Richard, Bunce Chris M., Heinrich Schrewe, Murray Jim A., Davies, Nicholas J., Drayson, Mark, Green, R., Schrewe, Heinrich, Mark R Viant, Davies Nicholas J., Jon P Ride, Mountford, J., Ride, J., Viant, M., Lodi Alessia, Drayson, M.T., Birtwistle, J., Hayden, Rachel E., Hayden Rachel E., Tiziani Stefano, Nicholas J Davies, Bunce, C.M., Ride Jon P., Hayden, R., Davies, N.J., Viant, M.R., Mountford Joanne C., Tiziani, S., Khanim, F., Birtwistle, Jane, Chris, M. Bunce, Schrewe Heinrich, Green, Richard M., Rachel E Hayden   +82 more
core   +1 more source

Treatment of Ph-positive Chronic Myeloid Leukemia with alpha-Interferon (Roferon-A). The Italian Cooperative Study Group experience.

, 1993
This is an interim report of two National studies of human recombinant interferon-alpha 2a (ROFERON-A) in Ph+ chronic myeloid leukemia (CML). The first study (1986-1988) enrolled 322 patients who were randomized to treatment by IFN or by hydroxyurea ...
The Italian Cooperative Study Group on Chronic Myeloid Leukemia, LIBERATI, Anna Marina   +1 more
core   +1 more source

Proteomics of Acute Myeloid Leukemia [PDF]

, 2007
Acute Myeloid Leukemia (AML) is characterized by specific cytogenetic aberrations that are strong determinants of prognostic outcome and therapeutic response.
Yaseen, Mumtaz
core   +1 more source

Reliability of Cell-Free DNA and Targeted NGS in Predicting Chromosomal Abnormalities of Patients With Myeloid Neoplasms

Frontiers in Oncology, 2022
IntroductionCytogenetic analysis is important for stratifying patients with various neoplasms. We explored the use of targeted next generation sequencing (NGS) in detecting chromosomal structural abnormalities or copy number variations (CNVs) in patients
Andrew Ip, Andrew Ip, Andrew Ip, Alexandra Della Pia, Alexandra Della Pia, Gee Youn (Geeny) Kim, Gee Youn (Geeny) Kim, Jason Lofters, James Behrmann, Dylon Patel, Simone Kats, Jeffrey Justin Estella, Ivan De Dios, Wanlong Ma, Andrew L. Pecora, Andrew L. Pecora, Andrew L. Pecora, Andre H. Goy, Andre H. Goy, Andre H. Goy, Jamie Koprivnikar, Jamie Koprivnikar, James K. McCloskey, James K. McCloskey, Maher Albitar   +24 more
doaj   +1 more source

CRISPR-Enabled Autonomous Transposable Element (CREATE) for RNA-based gene editing and delivery

EMBO Reports
To address a wide range of genetic diseases, genome editing tools that can achieve targeted delivery of large genes without causing double-strand breaks (DSBs) or requiring DNA templates are necessary.
Yuxiao Wang, Ruei-Zeng Lin, Meghan Harris, Bianca Lavayen, Neha Diwanji, Bruce McCreedy, Robert Hofmeister, Daniel Getts   +7 more
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Characterisation of the role of KLF5 in normal haemopoiesis and acute myeloid leukaemia. [PDF]

, 2011
Krüppel-like factor 5 (KLF5) encodes a zinc finger transcription factor involved in growth, differentiation and apoptosis of a number of different tissues, and it has previously been implicated as either a tumour suppressor or oncogene in various solid ...
Diakiw, Sonya
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source