Results 61 to 70 of about 604,501 (260)
Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection
Frontiers in Immunology, 2019 Dendritic cells (DCs) play important roles in orchestrating host immunity against invading pathogens, representing one of the first responders to infection by mucosal invaders.
Jake William Rhodes +6 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
High-Resolution Genome-Wide Single Nucleotide Polymorphism Mapping in Acute Myeloid Leukaemia [PDF]
, 2008 PhDInvestigation of the genetics of acute myeloid leukaemia (AML) has revealed the underlying basis of the disease and led to targets for therapy. High-resolution single nucleotide polymorphism (SNP) arrays detected regions of loss of heterozygosity ...
Raghavan, Manoj
core +2 more sources
A model for the functional assessment of elderly with myeloid neoplasms
Revista Brasileira de Hematologia e Hemoterapia, 2015 Objective: Myeloid neoplasms are heterogeneous diseases that are more incident in the elderly. The goals of this study were to aggregate a geriatric approach to the patient assessment, to show the impact of gender, age, hemoglobin concentration and ...
Ana Lúcia Ippolito Carbonell +4 more
doaj +1 more source
Granulomatous rosacea: Like leukemid in a patient with acute myeloid leukemia [PDF]
Vojnosanitetski Pregled, 2008 Introduction. Skin findings in leukemias may be divided into specific lesions (leukemia cutis) and non-specific lesions (leukemids) which may be found in up to 80% of all patients with leukemias.
Škiljević Dušan +4 more
doaj +1 more source
Eradication of chronic myeloid leukemia stem cells: a novel mathematical model predicts no therapeutic benefit of adding G-CSF to imatinib [PDF]
, 2009 Imatinib mesylate induces complete cytogenetic responses in patients with chronic myeloid leukemia (CML), yet many patients have detectable BCR-ABL transcripts in peripheral blood even after prolonged therapy.
Holyoake, T. +14 more
core +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
eJHaemBackground Acute myeloid leukaemia (AML) is an aggressive and heterogeneous malignant disease. Patient age, comorbidities and disease‐specific genetic abnormalities are recognized as primary determinants of treatment response.
Espen Talseth Skar +2 more
doaj +1 more source
Illuminating the Role of Vpr in HIV Infection of Myeloid Cells
Frontiers in Immunology, 2019 Vpr is a 14 kDa accessory protein conserved amongst extant primate lentiviruses that is required for virus replication in vivo. Although many functions have been attributed to Vpr, its primary role, and the function under selective pressure in vivo ...
Sarah Beth Nodder, Suryaram Gummuluru
doaj +1 more source
Myeloid-derived suppressor cells in gliomas
, 2016 Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of early myeloid progenitors and precursors at different stages of differentiation into granulocytes, macrophages, and dendritic cells.
Bozena Kaminska, Anna Gieryng
core +1 more source