Results 121 to 130 of about 71,029 (345)

Time Trends and Geographical Distribution of Childhood Leukaemia in Basrah, Iraq,from 2004 to 2009

Sultan Qaboos University Medical Journal, 2011
Objectives: This study aimed to assess the incidence and trend of childhood leukaemia in Basrah. Methods: This was a hospital-based cancer registry study carried out at the Pediatric Oncology Ward, Maternity & Children’s Hospital and other institutes in ...
Laith A Alrudainy, Jenan G Hassan, Hussam M Salih, Mohammed K Abbas, Athar AS Majeed   +4 more
doaj  

Identification of genes involved in leukaemia and differentiation induced by activated mutants of the GM-CSF receptor β subunit. [PDF]

, 2005
Interleukin (IL)-3, IL-5 and granulocyte-macrophage-colony-stimulating factor (GM-CSF) are cytokines that affect the growth, survival and differentiation of many cells within the haematopoietic system.
Reynolds, Brenton James
core   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Chronic myeloid leukaemia in Central Africans

East African Medical Journal, 2004
To document the pattern of presenting clinical and haematological features of chronic myeloid leukaemia (CML) in central Africans and evaluate the clinical consequences of treating the disease with chemotherapy.Prospective descriptive analysis of clinical and haematological data.Departments of Haematology of tertiary referral centres and teaching ...
Mukiibi, JM, Nyirenda, CM, Paul, B, Adewuyi, JO, Mzula, EL, Malata, HN   +5 more
openaire   +4 more sources

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Detection of BCR-ABL kinase domain mutations in CD34+ cells from newly diagnosed chronic phase CML patients and their association with imatinib resistance [PDF]

, 2011
BCR-ABL kinase domain (KD) mutations, the most common cause of imatinib resistance, are infrequently detected in newly diagnosed chronic-phase chronic myeloid leukemia (CP-CML) patients.
Aamer Aleem, Abdul Qayyum, Abid Jamil, Abid Taj, Ahmad Khalid, Ammara Tahir, Ijaz Shah, Mahwish Khan, Mubashar Naqvi, Mudassar Iqbal, Muhammad Abbad, Muhammad Ferhan, Muhammad Khalid, Najeeb ur-Rehman, Riaz ul-Haq, Shahid Baig, Tanveer Akhtar, Tariq Gill, Weng Qin, Zafar Iqbal   +19 more
core   +1 more source

Diagnostic radiography as a risk factor for chronic myeloid and monocytic leukaemia (CML) [PDF]

, 1989
Susan Preston‐Martin, DC Thomas, M-C. Yu, BE Henderson   +3 more
openalex   +1 more source

COVID‐19 infection in chronic myeloid leukaemia after one year of the pandemic in Italy. A Campus CML report [PDF]

, 2021
Massimo Breccia, Elisabetta Abruzzese, Vincenzo Accurso, Immacolata Attolico, Sara Barulli, Micaela Bergamaschi, Gianni Binotto, Monica Bocchia, Massimiliano Bonifacio, Giovanni Caocci, Isabella Capodanno, Fausto Castagnetti, Francesco Cavazzini, Elena Crisà, Monica Crugnola, Maria Stella De Candia, Chiara Elena, Carmen Fava, Sara Galimberti, Antonella Gozzini, Gabriele Gugliotta, Tamara Intermesoli, Alessandra Iurlo, Gaetano La Barba, Roberto Latagliata, Sabrina Leonetti Crescenzi, Luciano Levato, Giuseppina Loglisci, Alessandro Lucchesi, Luigiana Luciano, Francesca Lunghi, Debora Luzi, Alessandra Malato, Maria Cristina Miggiano, Pizzuti Michele, Patrizia Pregno, Davide Rapezzi, Giovanna Rege‐Cambrin, Gianantonio Rosti, Sabina Russo, Rosaria Sancetta, Anna Rita Scortechini, Federica Sorà, Paolo Sportoletti, Fabio Stagno, Agostino Tafuri, Mario Tiribelli, Robin Foà, Giuseppe Saglio   +48 more
openalex   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Auto-Commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells”

Molecular & Cellular Oncology, 2018
We have recently uncovered an abnormal increase in mitochondrial oxidative metabolism in therapy-resistant chronic myeloid leukaemia stem cells (LSCs).
Lucie de Beauchamp, Pablo Baquero, Elodie M. Kuntz, Eyal Gottlieb, G. Vignir Helgason   +4 more
doaj   +1 more source