Results 231 to 240 of about 71,029 (345)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia. [PDF]

Nature
Kamizela AE, Leongamornlert D, Williams N, Wang X, Nyamondo K, Dawson K, Spencer Chapman M, Guo J, Lee J, Mane K, Milne K, Green AR, Chevassut T, Campbell PJ, Ellinor PT, Huntly BJP, Baxter EJ, Nangalia J.   +17 more
europepmc   +1 more source

Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: clinical results from a randomised phase‐2 study (NordCML006) [PDF]

, 2014
Henrik Hjorth‐Hansen, Leif Stenke, Stina Söderlund, Arta Dreimane, Hans Ehrencrona, Tobias Gedde‐Dahl, Bjørn Tore Gjertsen, Martin Höglund, Perttu Koskenvesa, Kourosh Lotfi, Waleed Majeed, Berit Markevärn, Lotta Ohm, Ulla Olsson‐Strömberg, Kari Remes, Merja Suominen, Bengt Simonsson, Kimmo Porkka, Satu Mustjoki, Johan Richter, the Nordic CML Study Group (NCMLSG)   +20 more
openalex   +1 more source

Elevated serum aminotransferases in an infant with failure to thrive: A clinicopathological case report

JPGN Reports, EarlyView.
Jamie M. Klapp, Lauren Nichols, Nicholas J. Gloude, Amber Hildreth, Kathleen B. Schwarz   +4 more
wiley   +1 more source

Rib Ewing Sarcomas in Children and Young Adults: A Large National Retrospective Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Purpose Ewing sarcoma (ES) is the most prevalent malignant thoracic tumor in childhood and young adults. This study reports the outcome of a national cohort treated in an international prospective trial for a localized rib ES, with a long follow‐up.
Audrey Claren, Alexandre Beige, Magali Morelle, Jérôme Doyen, Cyril Lervat, Luc Ollivier, Cécile Vérité, Perrine Marec‐Bérard, Maria Jolnerovski, Anne Ducassou, Valentine Martin, Line Claude, French Multidisciplinary Working Group on Bone Primary Tumours (GROUPOS), GSF (French Sarcoma Group), GETO (Bone Tumour Study Group) and SFCE (French Society for the Fight against Childhood and Adolescent Cancer and Leukaemia)   +14 more
wiley   +1 more source

Dasatinib-Induced Pulmonary Arterial Hypertension in Chronic Myeloid Leukaemia: A Case Report and Literature Review. [PDF]

Respirol Case Rep
Krishnan S, Adigopula S.
europepmc   +1 more source

CLONAL STRUCTURES OF LEUKAEMIA STEM CELL POPULATIONS IN MYELOID BLAST PHASE CHRONIC MYELOID LEUKAEMIA

, 2016
Dimitris Karamitros, Helen Morrison, Ross Kinstrie, Nicolas Goardon, R E Clark, Mhairi Copland, Paresh Vyas   +6 more
openalex   +1 more source

Guidelines for the measurement of BCR‐ABL1 transcripts in chronic myeloid leukaemia [PDF]

, 2011
Letizia Foroni, Gill Wilson, Gareth Gerrard, Joanne Mason, David Grimwade, Helen White, David González de Castro, Stephen J. Austin, Abida Awan, Emma Burt, Tim Clench, Joanna Farruggia, Jeremy Hancock, Alexandra E. Irvine, Aytug Kizilors, Stephen E. Langabeer, B. Milner, Guillermina Nickless, Anna Schuh, Anne M. Sproul, Lihui Wang, Caroline Wickham, Nicholas C.P. Cross   +22 more
openalex   +1 more source

The Evolution of Pneumocystis jirovecii Pneumonia Prophylaxis for Pediatric Patients With Extracranial Solid Tumors: A Review of Historical Insights and Future Directions

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pneumocystis jirovecii pneumonia (PJP) remains a modern‐day complication for pediatric patients receiving treatment for extracranial solid tumors (ST), highlighting the need for reconsideration of our current approach toward PJP prophylaxis. This critical review aims to evaluate both universal and risk‐stratified approaches to PJP prophylaxis ...
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source