Results 301 to 310 of about 71,029 (345)
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Chronic myeloid leukaemia-associated retinopathy
BMJ Case Reports, 2021A 38-year-old man presented with mild blurring of vision in both eyes for the past 1 week. On examination, the retinal vessels were dilated and tortuous, along with multiple dot blot haemorrhages all over the fundus with yellowish white focal retinal infiltrates at the macula temporal to the fovea.
Ashish, Khalsa +2 more
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Medicine, 2004
Abstract Chronic myeloid leukaemia (CML, previously termed ‘chronic granulocytic leukaemia' or ‘chronic myelogenous leukaemia') appears to result from acquisition in a single pluripotent haemopoietic stem cell of a molecular lesion that causes inappropriate expansion of its progeny.
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Abstract Chronic myeloid leukaemia (CML, previously termed ‘chronic granulocytic leukaemia' or ‘chronic myelogenous leukaemia') appears to result from acquisition in a single pluripotent haemopoietic stem cell of a molecular lesion that causes inappropriate expansion of its progeny.
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Medicine, 2013
Chronic myeloid leukaemia (CML) is a clonal disorder in which cells of the myeloid lineage undergo inappropriate clonal expansion, caused by a BCR–ABL1 fusion gene resulting from a balanced translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11), also known as the Philadelphia (Ph) chromosome.
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Chronic myeloid leukaemia (CML) is a clonal disorder in which cells of the myeloid lineage undergo inappropriate clonal expansion, caused by a BCR–ABL1 fusion gene resulting from a balanced translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11), also known as the Philadelphia (Ph) chromosome.
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Dynamics of chronic myeloid leukaemia
Nature, 2005The clinical success of the ABL tyrosine kinase inhibitor imatinib in chronic myeloid leukaemia (CML) serves as a model for molecularly targeted therapy of cancer, but at least two critical questions remain. Can imatinib eradicate leukaemic stem cells? What are the dynamics of relapse due to imatinib resistance, which is caused by mutations in the ABL ...
Michor, F. +6 more
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Staging of Chronic Myeloid Leukaemia
British Journal of Haematology, 1981Summary. The prognostic value of nine clinical and haematological features, recorded at diagnosis in chronic myeloid leukaemia (CML), was analysed in two distinct series of patients. One series (116 cases) was collected at a single hospital over a 12‐year period.
Tura, S +4 more
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2018
Chronic myeloid leukaemia (CML) was recognized in the 1970s by Janet Rowley to be a genetically simple malignancy; resulting as a consequence of a balanced translocation between chromosome 9 and 22. This provided vital insights into the molecular aberration, in the 1990s, which ushered in the current ‘precision medicine’ era, not only for patients of ...
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Chronic myeloid leukaemia (CML) was recognized in the 1970s by Janet Rowley to be a genetically simple malignancy; resulting as a consequence of a balanced translocation between chromosome 9 and 22. This provided vital insights into the molecular aberration, in the 1990s, which ushered in the current ‘precision medicine’ era, not only for patients of ...
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Ph‐negative chronic myeloid leukaemia
British Journal of Haematology, 1987SummaryAn analysis of five patients with Philadelphia chromosome (Ph) negative chronic myeloid leukaemia (CML) revealed that two were clinically and haematologically identical to Ph‐positive CML whereas three should be reclassified as chronic myelomonocytic leukaemia (CMML). At a molecular level the first two patients showed the same juxtaposition of c‐
P H, Fitzgerald +4 more
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Chronic myeloid leukaemia in childhood
The Indian Journal of Pediatrics, 19631. Seven patients with chronic myeloid leukaemia who came under our observations during the years 1957 to 1961 are reported. 2. Certain peculiarities of the childhood form of this disease are mentioned. 3. Some possible aetiological factors are discussed.
L, RAMAKUMAR +3 more
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Cytogenetics of chronic myeloid leukaemia
Best Practice & Research Clinical Haematology, 2001The standard Philadelphia (Ph) translocation t(9;22), its variants and a proportion of Ph-negative cases are positive for the BCR-ABL fusion gene, as determined by molecular analysis. Extensive deletions of chromosome 9 and 22 derived sequences around the translocation breakpoints on the derivative 9 are seen in 10-30% of patients at diagnosis and may ...
Chase, Andrew +2 more
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Graft vs. Leukaemia reactions in chronic myeloid leukaemia
European Journal of Cancer, 1992A 39-year-old female relapsed 36 months after allogeneic bone marrow transplantation for chronic myeloid leukaemia. Infusion of peripheral blood leucocytes from her bone marrow donor resulted in complete remission, and she remains leukaemia-free 18 months later. This case provides direct evidence for a 'graft vs. leukaemia' (GVL) effect contributing to
J O, Cullis, A J, Barrett, J M, Goldman
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