Results 311 to 320 of about 125,713 (396)

The Fortunes of Genomic Medicine: A Quarter Century of Promise

Annals of Human Genetics, EarlyView.
ABSTRACT Background The culmination of the Human Genome Project in the early 2000s came wreathed in promises of a revolution in medicine and healthcare. The ensuing quarter century has seen remarkable growth in genomic medicine, as well as notable shifts in the promissory rhetoric that accompanies it.
Steve Sturdy
wiley   +1 more source

Myelofibrosis predicts deep molecular response 4.5 in chronic myeloid leukaemia patients initially treated with imatinib: An extensive, multicenter and retrospective study to develop a prognostic model. [PDF]

Clin Transl Med
Zeng T, Yang X, Wang Y, Wu D, Feng W, Lu Y, Zhu X, Liu L, Zhou M, Zhang L, Shao Y, Qian H, Zhu F, Chen Y, Cao D, Huang L, Feng X, Chen L, Zhang G, Le J, Zhu W, Xia Y, Han Y, Jia Y, Tian G, Zhou H, Xu L, Yin X, Tang Q, Zhang Y, Yao G, Lang X, Zhang K, Zhou X, Guo J, Tu J, Zhao J, Wu G, Zhang H, Wu X, Luo Q, Cao L, Chu B, Jiang W, Wu H, Huang L, Hu M, He M, Zhu J, Tong H, Jin J, Huang J.   +51 more
europepmc   +1 more source

Dual Inhibition of Mast Cells and Thymic Stromal Lymphopoietin Using a Novel Bispecific Antibody, CDX‐622

Allergy, EarlyView.
SCF and TSLP expression are known to drive unique immune responses leading to the onset of allergic and inflammatory diseases. Here, we describe the characterization of a novel bsAb, CDX‐622, that targets SCF and TSLP. CDX‐622 inhibits MC functions through SCF starvation and Type 2 inflammatory responses via TSLP inhibition.
Michael B. Murphy, Laura Vitale, Thomas O'Neill, Deena M. Maurer, Linda Malenchek, Andrea Crocker, Colleen Patterson, Laura Mills‐Chen, Virginia Saley, Nicole M. Antczak, James M. Boyer, Kelly M. McManus, Noe Rico Montanari, Russell A. Hammond, Joel Goldstein, Lawrence J. Thomas, Tibor Keler, Diego Alvarado   +17 more
wiley   +1 more source

Goodbye to accelerated phase of chronic myeloid leukaemia

Jiang Q, Yang S, Zhang X, Gale R, Huang X.   +4 more
europepmc   +1 more source

Raddeanin A augments the cytotoxicity of natural killer cells against chronic myeloid leukaemia cells by modulating MAPK and Ras/Raf signalling pathways. [PDF]

J Cell Mol Med
Hsieh MJ, Lin JT, Chuang YC, Lo YS, Lin CC, Ho HY, Chen MK.   +6 more
europepmc   +1 more source

Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro

Andrology, EarlyView.
Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert, Sini Laasanen, Mirja Nurmio, Aida Wahlgren, Kirsi Jahnukainen, Kim Eerola, Miisael Nieminen, Opeyemi Olotu, Noora Kotaja, Juho‐Antti Mäkelä, Jorma Toppari   +10 more
wiley   +1 more source

A non‐hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation

Andrology, EarlyView.
Abstract Background and objectives Epididymal transit renders key competence to mammalian spermatozoa for fertilizing eggs. Generally, the two paralogs of glycogen synthase kinase 3, GSK3α and GSK3β, functionally overlap except in testis and sperm. We showed that GSK3α is essential for epididymal sperm maturation and fertilization.
Mustfa Kabi, Aditi Khamamkar, Kwaku Kyei‐Baffour, Michel Weïwer, Srinivasan Vijayaraghavan, Souvik Dey   +5 more
wiley   +1 more source

Prevalence of Asymptomatic Premalignant Oesophageal Lesions in Patients With Fanconi Anaemia

Alimentary Pharmacology &Therapeutics, EarlyView.
Clinically relevant endoscopic findings in asymptomatic Fanconi Anemia patients. ABSTRACT Fanconi anaemia (FA), a rare genetic disorder of DNA repair, predisposes to squamous cell carcinomas of head, neck and oesophagus. We assessed the value of screening esophagogastroduodenoscopy (EGD) in 20 asymptomatic adults (median age 23.5, 65% female) with FA ...
Joshua A. Sloan, Nicha Wongjarupong, Vikram Christian, Nabeel Azeem, Kevin O. Turner, C. Prakash Gyawali, Margaret L. MacMillan, John E. Wagner   +7 more
wiley   +1 more source

What do atomic bomb survivors teach us about therapy-free remission in people with chronic myeloid leukaemia? [PDF]

Leukemia
Radivoyevitch T, Gale RP, Kalaycio ME.
europepmc   +1 more source