Results 331 to 340 of about 125,713 (396)
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Journal of Clinical Nursing, 2021
AIMS AND OBJECTIVES To investigate the relationship between illness uncertainty, self-perceived burden and quality of life and explore the mediating role of self-perceived burden between illness uncertainty and quality of life in patients with chronic ...
Nan Zhang +6 more
semanticscholar +1 more source
AIMS AND OBJECTIVES To investigate the relationship between illness uncertainty, self-perceived burden and quality of life and explore the mediating role of self-perceived burden between illness uncertainty and quality of life in patients with chronic ...
Nan Zhang +6 more
semanticscholar +1 more source
The Lancet, 2015
Chronic myeloid leukaemia (CML) was the first leukaemia associated with a unique genetic abnormality, the Philadelphia chromosome. This results from a reciprocal translocation between chromosomes 9 and 22, which generates the BCR-ABL1 fusion gene encoding a constitutively active tyrosine kinase.
Junia V. Melo, Debora A. Casolari
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Chronic myeloid leukaemia (CML) was the first leukaemia associated with a unique genetic abnormality, the Philadelphia chromosome. This results from a reciprocal translocation between chromosomes 9 and 22, which generates the BCR-ABL1 fusion gene encoding a constitutively active tyrosine kinase.
Junia V. Melo, Debora A. Casolari
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TARGET: a survey of real‐world management of chronic myeloid leukaemia across 33 countries
British Journal of Haematology, 2020Despite the availability of guidelines for the management of chronic myeloid leukaemia (CML), various issues may prevent their successful implementation.
A. Turkina +10 more
semanticscholar +1 more source
The Lancet, 2007
Chronic myeloid leukaemia (CML) was the first neoplastic disease for which knowledge of the genotype led to a rationally designed therapy. As a result of its well known pathophysiology, straightforward diagnosis, well established prognostic factors, and treatment for the cause of disease, CML has been studied to an extent that far exceeds that expected
Hehlmann R +3 more
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Chronic myeloid leukaemia (CML) was the first neoplastic disease for which knowledge of the genotype led to a rationally designed therapy. As a result of its well known pathophysiology, straightforward diagnosis, well established prognostic factors, and treatment for the cause of disease, CML has been studied to an extent that far exceeds that expected
Hehlmann R +3 more
openaire +4 more sources
Oxford Textbook of Medicine, 2020
Chronic myeloid leukaemia (CML) has a worldwide incidence of 1 to 2 per 100 000 of the population. Most cases are caused by translocation of the distal end of chromosome 9 on to chromosome 22 which leads to the creation of a fusion protein expressed from
M. Copland, T. Holyoake
semanticscholar +1 more source
Chronic myeloid leukaemia (CML) has a worldwide incidence of 1 to 2 per 100 000 of the population. Most cases are caused by translocation of the distal end of chromosome 9 on to chromosome 22 which leads to the creation of a fusion protein expressed from
M. Copland, T. Holyoake
semanticscholar +1 more source
Staging of Chronic Myeloid Leukaemia
British Journal of Haematology, 1981Summary. The prognostic value of nine clinical and haematological features, recorded at diagnosis in chronic myeloid leukaemia (CML), was analysed in two distinct series of patients. One series (116 cases) was collected at a single hospital over a 12‐year period.
Tura, S +4 more
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Dynamics of chronic myeloid leukaemia
Nature, 2005The clinical success of the ABL tyrosine kinase inhibitor imatinib in chronic myeloid leukaemia (CML) serves as a model for molecularly targeted therapy of cancer, but at least two critical questions remain. Can imatinib eradicate leukaemic stem cells? What are the dynamics of relapse due to imatinib resistance, which is caused by mutations in the ABL ...
Martin A. Nowak +7 more
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Chronic myeloid leukaemia in childhood
The Indian Journal of Pediatrics, 19631. Seven patients with chronic myeloid leukaemia who came under our observations during the years 1957 to 1961 are reported. 2. Certain peculiarities of the childhood form of this disease are mentioned. 3. Some possible aetiological factors are discussed.
L. Ramakumar +3 more
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Cytogenetics of chronic myeloid leukaemia
Best Practice & Research Clinical Haematology, 2001The standard Philadelphia (Ph) translocation t(9;22), its variants and a proportion of Ph-negative cases are positive for the BCR-ABL fusion gene, as determined by molecular analysis. Extensive deletions of chromosome 9 and 22 derived sequences around the translocation breakpoints on the derivative 9 are seen in 10-30% of patients at diagnosis and may ...
Chase, Andrew +2 more
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What is New in Chronic Myeloid Leukaemia? [PDF]
Scottish Medical Journal, 2007 Chronic myeloid leukaemia is a relatively rare condition, though it has stimulated widespread interest as a consequence of both the stem cell basis and the success of rationally designed therapies. This review will outline some of the issues involving the aetiology of the disease and how this relates to current and future therapies.
Tessa L. Holyoake, Nicholas B. Heaney
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