Results 71 to 80 of about 125,713 (396)
Respirology Case Reports, 2021 Dasatinib is a potent and effective second‐generation oral tyrosine kinase inhibitor that is clinically indicated for the treatment of imatinib‐resistant or imatinib‐intolerant breakpoint cluster region‐Abelson (BCR‐ABL)‐positive chronic myeloid ...
Chao‐Chin Hsu +2 more
doaj +1 more source
Sudden blastic transformation in treatment‐free remission chronic myeloid leukaemia
British Journal of Haematology, 2019 Chronic myeloid leukaemia (CML) progresses through three distinct phases, referred to as chronic, accelerated and blast. With the emergence of tyrosine kinase inhibitors (TKIs), and more recently the success of TKI discontinuation (Ross et al, 2013 ...
M. Alfayez +7 more
semanticscholar +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Assembling defenses against therapy-resistant leukemic stem cells: Bcl6 joins the ranks [PDF]
, 2011 The resistance of leukemic stem cells in response to targeted therapies such as tyrosine kinase inhibitors (TKIs) relies on the cooperative activity of multiple signaling pathways and molecules, including TGFβ, AKT, and FOXO transcription factors ...
Austin +30 more
core +2 more sources
Paediatric chronic myeloid leukaemia: Is it really a different disease?
The Indian journal of medical research, 2019 Paediatric chronic myeloid leukaemia (CML) has biological and clinical differences from adult CML. Management of paediatric CML presents unique challenges in growing children, and there are no specific guidelines for paediatric CML.
D. Pushpam, S. Bakhshi
semanticscholar +1 more source
Identification of genes involved in leukaemia and differentiation induced by activated mutants of the GM-CSF receptor β subunit. [PDF]
, 2005 Interleukin (IL)-3, IL-5 and granulocyte-macrophage-colony-stimulating factor (GM-CSF) are cytokines that affect the growth, survival and differentiation of many cells within the haematopoietic system.
Reynolds, Brenton James
core +1 more source
Acute Myeloid Leukaemia Presenting as B12 Vitamin Deficiency When Multiple Horses Become a Zebra
European Journal of Case Reports in Internal Medicine, 2022 Vitamin B12 deficiency is a common finding in medical practice. It is easily treated with supplementation and typically has a favourable prognosis. In rare circumstances, it can hide a severe disease that should be promptly addressed.
Diana Ferrao +2 more
doaj +1 more source
Large amplicon droplet digital PCR for DNA‐based monitoring of pediatric chronic myeloid leukaemia
Journal of Cellular and Molecular Medicine, 2019 Quantification of tumour‐specific molecular markers at the RNA and DNA level for treatment response monitoring is crucial for risk‐adapted stratification and guidance of individualized therapy in leukaemia and other malignancies.
M. Krumbholz +5 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia [PDF]
, 2014 Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene. Although mechanisms of BCR/ABL1-induced transformation are well-defined, little is known about effector-molecules contributing to malignant expansion and ...
Bilban, Martin +15 more
core +1 more source