Results 91 to 100 of about 427,029 (392)

Pre‐Administration of Akkermansia Muciniphila Prevents the Development of Severe Acute Graft‐Versus‐Host Disease in Systemic Organs

Advanced Science, EarlyView.
Akkermansia muciniphila, a next‐generation probiotic, alleviates acute graft‐versus‐host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) by providing protective effects across multiple organs. Pre‐colonization with A.
Jeong‐Eun Han, Dae‐Seong Lee, Su‐Won Jeong, Ji‐Hyun Yun, Seomin Kang, Seoyoung Jang, EunAh Lee, Ju Hye Baek, Che Ok Jeon, Jin‐Woo Bae   +9 more
wiley   +1 more source

Indole-3-carbinol induces apoptosis of chronic myelogenous leukemia cells through suppression of STAT5 and Akt signaling pathways

Tumor Biology, 2017
Signal transducer and activator of transcription 5 and Akt pathways, implicated in signaling transduction downstream of BCR–ABL, play critical roles in the pathogenesis of chronic myeloid leukemia.
Majid Safa, Leila Jafari, Fatemeh Alikarami, Rima Manafi Shabestari, Ahmad Kazemi   +4 more
doaj   +1 more source

Low expression of miR-196b enhances the expression of BCR-ABL1 and HOXA9 oncogenes in chronic myeloid leukemogenesis. [PDF]

PLoS ONE, 2013
MicroRNAs (miRNAs) can function as tumor suppressors or oncogene promoters during tumor development. In this study, low levels of expression of miR-196b were detected in patients with chronic myeloid leukemia.
Yue Liu, Wenling Zheng, Yanbin Song, Wenli Ma, Hong Yin   +4 more
doaj   +1 more source

Tyrosine Kinase Inhibitors Available for Chronic Myeloid Leukemia: Efficacy and Safety

Frontiers in Oncology, 2019
Chronic myeloid leukemia (CML) is currently a disease in which patients can enjoy a near normal life-expectancy. However, since the majority of patients will need to remain on treatment indefinitely, physicians in care of CML patients need be familiar ...
V. García‐Gutiérrez, J. Hernández-Boluda   +1 more
semanticscholar   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

The role of natural killer cells in chronic myeloid leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2011
Chronic myeloid leukemia is a neoplasia resulting from a translocation between chromosomes 9 and 22 producing the BCR-ABL hybrid known as the Philadelphia chromosome (Ph).
Anna Carolyna Araújo Danier, Ricardo Pereira de Melo, Marcelo Henrique Napimoga, Maria Theresa Cerávolo Laguna-Abreu   +3 more
doaj   +1 more source

Biological aspects of mTOR in leukemia [PDF]

, 2018
The mammalian target of rapamycin (mTOR) is a central processor of intra-and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival.
Bianchi, Mp, Gianfelici, V, Mirabilii, S, Piedimonte, M, Ricciardi, Mr, Tafuri, A.   +5 more
core   +1 more source

Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants

Leukemia, 2017
Chronic myeloid leukemia (CML)-study IV was designed to explore whether treatment with imatinib (IM) at 400 mg/day (n=400) could be optimized by doubling the dose (n=420), adding interferon (IFN) (n=430) or cytarabine (n=158) or using IM after IFN ...
R. Hehlmann, Michael Lauseker, Susanne Saussele, Markus Pfirrmann, S. Krause, Kolb Hj, Andreas Neubauer, D. Hossfeld, C. Nerl, A. Gratwohl, G. Baerlocher, D. Heim, T. Brümmendorf, A. Fabarius, C. Haferlach, B. Schlegelberger, M. Müller, S. Jeromin, Ulrike Proetel, K. Kohlbrenner, A. Voskanyan, S. Rinaldetti, W. Seifarth, B. Spiess, L. Balleisen, M. Goebeler, M. Hänel, A. Ho, J. Dengler, C. Falge, Lothar Kanz, Stephan Kremers, Andreas Burchert, M. Kneba, F. Stegelmann, C. Köhne, H. Lindemann, C. Waller, Michael Pfreundschuh, K. Spiekermann, We Berdel, Lutz P. Müller, Matthias Edinger, J. Mayer, D. Beelen, M. Bentz, H. Link, B. Hertenstein, R. Fuchs, M. Wernli, F. Schlegel, R. Schlag, M. D. Wit, L. Trümper, H. Hebart, M. Hahn, J. Thomalla, C. Scheid, P. Schafhausen, W. Verbeek, M. Eckart, W. Gassmann, A. Pezzutto, M. Schenk, P. Brossart, T. Geer, S. Bildat, E. Schäfer, A. Hochhaus, J. Hasford   +69 more
semanticscholar   +1 more source

Chronic Myeloid Leukemia in 2020

HemaSphere, 2020
New insights have emerged from maturing long-term academic and commercial clinical trials regarding optimum management of chronic myeloid leukemia (CML).
R. Hehlmann
semanticscholar   +1 more source

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, EarlyView.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source