Results 201 to 210 of about 399,367 (396)

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Philadelphia-negative (Ph-) chronic myeloid leukemia (CML): comparison with Ph+ CML and chronic myelomonocytic leukemia. The Groupe Francais de Cytogenetique Hematologique [PDF]

, 1991
P. Martiat, Jl. Michaux, J Rodhain
openalex   +1 more source

Adjuvant External Beam Radiotherapy in Differentiated Thyroid Cancers: An Audit of Clinical Practice, Adapting to New Evidence

Head &Neck, EarlyView.
ABSTRACT Introduction There is limited evidence on the role of adjuvant external beam radiotherapy in differentiated thyroid cancer (DTC). Methods We conducted a retrospective study of patients with DTC treated with adjuvant Intensity Modulated radiotherapy (IMRT) from 2011 to 2024.
Sarbani Ghosh Laskar, Samarpita Mohanty, Shwetabh Sinha, Anuj Kumar, Gouri Pantvaidya, Shivakumar Thiagarajan, Ashwini Budrukkar, Monali Swain, Anuja Deshmukh, Deepa Nair, Richa Vaish, Vidisha Tuljapurkar, Chandrashekhar Dravid, Sudhir Nair, Poonam Joshi, Rathan Shetty, Arjun Gurmeet Singh, Pankaj Chaturvedi   +17 more
wiley   +1 more source

Features of the molecular expression of alkaline phosphatase gene in chronic myeloid leukemia

, 1970
L. P. Shvachko, I. V. Kravchuk, G. D. Teleheiev   +2 more
openalex   +1 more source

Autografting with cultured marrow in chronic myeloid leukemia: results of a pilot study [see comments] [PDF]

, 1994
MJ Barnett, CJ Eaves, GL Phillips, R. D. Gascoyne, Donna E. Hogge, DE Horsman, R. Keith Humphries, Klingemann Hg, PM Lansdorp, SH Nantel   +9 more
openalex   +1 more source

Feasibility of iFISH patterns in hematologic malignancies among Congolese patients at Kinshasa University clinics

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To analyze the feasibility of detecting Ph1 in leukemia patients in the Kinshasa University Clinics in the Democratic Republic of Congo, at KU Leuven, Belgium.
Mireille Solange Nganga Nkanga, Benjamin Longo-Mbenza, Peter Vandenberghe, Fons Verdonck, Venant Tchokonte-Nana, Nkama Claude Nlandu, Roth Laure Mapapa Miakassissa, Paul Roger Beia Kazadi, Antoine Lufimbo Katawandja, Jacques Bikaula Ngwidiwo, Ntolo Jean-Pierre Mufuta, Kuanda Thomas Solo, Mbombo Aurore Cecilia Orphée Beia   +12 more
doaj  

Inadvertent Transmission of a Donor's Acute Myeloid Leukemia in Bone Marrow Transplantation for Chronic Myelocytic Leukemia [PDF]

, 1990
Dietger Niederwieser, Frederick R. Appelbaum, Günther Gastl, Elisabeth Gersdorf, Bernhard Meister, D. Geißler, J. A. Tratkiewicz, Josef Thaler, Christoph Huber   +8 more
openalex   +1 more source

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

International Journal of Cancer, EarlyView.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner, Jayant Y. Gadrey, Scott A. Armstrong, Michael W. M. Kühn   +3 more
wiley   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Increased erythropoietin-receptor expression on CD34-positive bone marrow cells from patients with chronic myeloid leukemia [PDF]

, 1992
AW Wognum, Gerald Krystal, CJ Eaves, AC Eaves, PM Lansdorp   +4 more
openalex   +1 more source