Results 211 to 220 of about 112,698 (266)

Asciminib demonstrates superior efficacy and safety in newly diagnosed chronic myeloid leukemia in the ASC4FIRST trial.

open access: yesBlood
Cortes JE   +20 more
europepmc   +1 more source

Chronic Myeloid Leukemia

New England Journal of Medicine, 1999
Over the past twenty years, clinical and laboratory studies have led to important new insights into the biology of chronic myeloid leukemia. Basic science has defined the molecular pathogenesis of chronic myeloid leukemia (CML) as unregulated signal transduction by the Bcr-Abl tyrosine kinase.
Charles L Sawyers, Sawyers Charles L
exaly   +3 more sources

The Biology of Chronic Myeloid Leukemia

New England Journal of Medicine, 1999
Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of transformed, primitive hematopoietic progenitor cells. It involves myeloid, monocytic, erythroid, megakaryocytic, B-lymphoid, and occasionally T-lymphoid lineages.1 CML was the first human disease in which a specific abnormality of the karyotype — the Philadelphia (Ph ...
Moshe Talpaz   +2 more
exaly   +3 more sources

Asciminib in chronic myeloid leukemia

Drugs of Today, 2022
Despite the fact that, in the last years, life expectancy of chronic myeloid leukemia (CML) patients has reached that of the normal population, a significant proportion of CML patients is likely to fail treatment with first- or second-generation tyrosine kinase inhibitors (TKIs).
Assanto, Giovanni Manfredi   +2 more
openaire   +3 more sources

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