Results 61 to 70 of about 772,617 (344)

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations

Nature Genetics, 2019
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from
P. Sakornsakolpat, Dmitry Prokopenko, M. Lamontagne, N. Reeve, A. Guyatt, V. Jackson, N. Shrine, D. Qiao, Traci M. Bartz, D. Kim, Mi Kyeong Lee, J. Latourelle, Xingnan Li, J. Morrow, M. Obeidat, A. Wyss, P. Bakke, R. Barr, T. Beaty, S. Belinsky, G. Brusselle, J. Crapo, K. Jong, D. Demeo, T. Fingerlin, S. Gharib, A. Gulsvik, I. Hall, J. Hokanson, W. Kim, D. Lomas, S. London, D. Meyers, G. O'Connor, S. Rennard, D. Schwartz, P. Śliwiński, D. Sparrow, D. Strachan, R. Tal-Singer, Y. Tesfaigzi, J. Vestbo, J. Vonk, J. Yim, Xiaobo Zhou, Y. Bossé, A. Manichaikul, L. Lahousse, E. Silverman, H. Boezen, L. Wain, M. Tobin, B. Hobbs, M. Cho, C. Batini, Jinghua Zhao, M. Wielscher, S. Weiss, K. Kentistou, J. Cook, J. Hui, S. Karrasch, M. Imboden, S. Harris, J. Marten, Stefan Enroth, S. Kerr, I. Surakka, V. Vitart, T. Lehtimäki, R. Ewert, C. Gieger, G. Homuth, Peter K. Joshi, C. Langenberg, L. Lind, J. Luan, A. Mahajan, Alison D. Murray, D. Porteous, R. Rawal, Blair H. Smith, P. Timmers, O. Raitakari, M. Kähönen, O. Polašek, U. Gyllensten, I. Rudan, I. Deary, N. Probst-Hensch, H. Schulz, A. James, James F. Wilson, B. Stubbe, E. Zeggini, M. Jarvelin, N. Wareham, C. Hayward, Andrew P Morris, A. Agustí, W. Anderson, N. Bakerly, R. Bals, Kathleen C. Barnes, E. Bleecker, Russell P Bowler, C. Brightling, Marleen de Bruijne, P. Castaldi, B. Celli, H. Coxson, R. Crystal, P. D. Jong, A. Dirksen, J. Dy, M. Foreman, J. Garcia-Aymerich, P. Gevenois, Soumitra Ghosh, H. Gietema, N. Hansel, C. Hersh, E. Hoffman, N. Kalsheker, H. Kauczor, Tarja Laitinen, D. Lambrechts, Sang-Do Lee, A. Litonjua, D. Loth, S. Lutz, D. Lynch, W. Macnee, Merry-Lynn N. McDonald, J. Newell, B. Nordestgaard, Y. Oh, P. Paré, M. Pistolesi, D. Postma, M. Puhan, E. Regan, S. Rich, J. Seo, Andrea B. Short, B. Stoel, N. Sverzellati, G. Riet, E. V. Beek, B. Ginneken, C. Vogelmeier, A. Wanner, G. Washko, E. Wauters, E. Wouters, R. P. Young, L. Zeigler-Heitbrock   +156 more
semanticscholar   +1 more source

Chronic Obstructive Pulmonary Disease

Veterinary Clinics of North America: Equine Practice, 1991
COPD continues to be a severe condition in horses. Despite increased understanding of its pathogenesis, there is relatively little information on effective treatment regimens. Management and prevention are critical, and more emphasis should be placed on improved housing, bedding, and feeding.
openaire   +2 more sources

Heterogeneity of Rheumatoid Arthritis–Associated Interstitial Lung Disease by Longitudinal Forced Vital Capacity Trajectory and Associations With Disease Outcomes

Arthritis Care &Research, EarlyView.
Objective We aimed to identify unique disease trajectories within rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) based on longitudinal forced vital capacity (FVC) values and their associated clinical outcomes. Methods We performed a cohort study of RA‐ILD within the Veterans Health Administration from 1999 to 2021.
Bryant R. England, Yangyuna Yang, Punyasha Roul, Tate M. Johnson, Scott M. Matson, Grant W. Cannon, Brian C. Sauer, Jeffrey R. Curtis, Joshua F. Baker, Ted R. Mikuls   +9 more
wiley   +1 more source

Trajectories of illness perceptions in persons with chronic Illness: An explorative longitudinal study [PDF]

, 2013
Accurate illness perceptions are essential to the self-management of chronic illness. This study explored trajectories of illness perceptions in persons with morbid obesity (n = 53) and persons with chronic obstructive pulmonary disease (n = 52 ...
Bonsaksen, Tore, Fagermoen, May Solveig, Lerdal, Anners   +2 more
core   +1 more source

Adipokines and Associations With Incident Osteoporotic Fracture in Patients With Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective We assessed whether circulating adipokines are associated with incident fractures in patients with rheumatoid arthritis (RA). Methods Three adipokines (adiponectin, leptin, and fibroblast growth factor [FGF]‐21) were measured using banked enrollment serum from participants in a longitudinal RA cohort.
Joshua F. Baker, Bryant R. England, Michael D. George, Hannah Brubeck, Brian Sauer, Aleksander Lenert, Punyasha Roul, Geoffrey M. Thiele, Ted R. Mikuls, Katherine D. Wysham   +9 more
wiley   +1 more source

The effects of atorvastatin in mustard gas exposed patients with chronic obstructive pulmonary disease: A randomized controlled trail [PDF]

Background: Statins have anti-inflammatory effects in patients with chronic obstructive pulmonary disease. This study designed to evaluate the effects of atorvastatin on serum highly sensitive C-reactive protein (hs-CRP) and pulmonary function in ...
قانعی, مصطفی, قبادی مراللو, حسن, محمدزاده لاری, شهرزاد, محمودپور, افسون, پورفرضی, فرهاد   +4 more
core  

The once-daily fixed-dose combination of olodaterol and tiotropium in the management of COPD : current evidence and future prospects [PDF]

, 2019
Long-acting bronchodilators are the cornerstone of pharmacologic treatment of chronic obstructive pulmonary disease (COPD). Spiolto (R) or Stiolto (R) is a fixed-dose combination (FDC) containing two long-acting bronchodilators, the long-acting ...
Brusselle, Guy, Derom, Eric, Joos, Guy
core   +1 more source

Clinical Outcomes of Patients Within the Rheumatoid Arthritis Care Pathway Cohort at a Tertiary Care Integrated Delivery Network: A Comparison to Usual Care

Arthritis Care &Research, EarlyView.
Objective We aimed to compare clinical outcomes between patients in the Allegheny Health Network rheumatoid arthritis (RA) care pathway and patients receiving usual care. Methods The care pathway initiative implements guideline‐based best practice alongside multidisciplinary team‐based care.
Tarun Sharma, Tyson S. Barrett, Teigan Dwyer, Nancy Campbell, Jessica Heintzinger, Ellen Kraemer, Adam Dore, Susan Manzi   +7 more
wiley   +1 more source

Systematic review on inhaled corticosteroid monotherapy and its efficacy and safety in longterm treatment of patients with chronic obstructive pulmonary disease (COPD) [PDF]

--chronic obstructive pulmonary disease,COPD,corticosteroids,systematic review,chronisch obstruktive Lungenerkrankung,COPD,Kortikosteroid,systematischer ...
Buchberger, Barbara, Kossmann, Beate, Neumann, Anja, Niebuhr, Dea, Wasem, Jürgen   +4 more
core  

Comparing the effectiveness of small-particle versus large-particle inhaled corticosteroid in COPD [PDF]

, 2014
Dirkje S Postma,1 Nicolas Roche,2 Gene Colice,3 Elliot Israel,4 Richard J Martin,5 Willem MC van Aalderen,6 Jonathan Grigg,7 Anne Burden,8 Elizabeth V Hillyer,8 Julie von Ziegenweidt,8 Gokul Gopalan,9 David Price8,10 1University of Groningen, Department ...
Burden, A, Colice, G, Gopalan, G, Grigg, J, Hillyer, EV, Israel, E, Martin, RJ, Postma, DS, Price, D, Roche, N, van Aalderen, WMC, von Ziegenweidt, J   +11 more
core   +6 more sources