Results 41 to 50 of about 1,011,898 (268)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Persistance with non-functional problem solving in chronic pain [PDF]

, 2010
Research has demonstrated the relationship between persistence with problem solving focussed on pain removal and increased levels of distress in the chronic pain population.
Wells, Caroline Elizabeth
core  

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Prevalence and impact of chronic widespread pain in the Bangladeshi and White populations of Tower Hamlets, East London [PDF]

, 2013
The prevalence and impact of chronic pain differ between ethnic groups. We report a study of the comparative prevalence and impact of chronic pain in Bangladeshi, British Bangladeshi and White British/Irish people.
Griffiths, Chris J., Anwara Ali, Hussain, Iqbal, Choudhury, Yasmin, Rahman, A. (Anisur), Ali, A, Anisur Rahman (11489), Chris J Griffiths (16217579), Iqbal Hussain (740428), Martin Underwood (16814), Stephen A. Bremner, Yasmin Choudhury, Eldridge, Sandra, Chris J. Griffiths, Underwood, Martin, Rahman, Anisur, Martin Underwood, Hussain, I. (Iqbal), Griffiths, CJ, Hussain, I, Eldridge, S, Yasmin Choudhury (16217573), Stephen Bremner (4465981), Suzanne Parsons (16808), Rahman, A, Iqbal Hussain, Anisur Rahman, Underwood, M, Bremner, SA, Choudhury, Y, Suzanne Parsons, Ali, Anwara, Sandra Eldridge (80747), Parsons, Suzanne, Parsons, S, Sandra Eldridge, Bremner, Stephen A., Anwara Ali (16217576)   +37 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

"I feel so stupid because I can't give a proper answer ..." How older adults describe chronic pain: a qualitative study [PDF]

, 2012
Background - Over 50% of older adults experience chronic pain. Poorly managed pain threatens independent functioning, limits social activities and detrimentally affects emotional wellbeing.
Clarke, Amanda, McNamee Paul, Anthony, Geraldine, Paul McNamee, Geraldine Anthony, Blair H Smith, Schofield Patricia, Martin Denis, Denise Gray, Martin, D., McNamee, P., Patricia Schofield, Amanda Clarke, Gray, D., Smith Blair H, Schofield, Patricia, Smith, Blair H; id_orcid, Smith, Blair H., Derek Jones, Jones Derek, Smith, B.H., McNamee, Paul, Clarke Amanda, Anthony Geraldine, Martin, Denis, Denis Martin, Martin, Denis; id_orcid, Jones, D., Gray, Denise, Anthony, G., Jones, Derek, Gray Denise, Smith, Blair, Clarke, A.   +33 more
core   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

The effects of yoga on patients chronic pain [PDF]

, 2004
Plan BChronic pain is a challenging and costly medical problem. Interest has increased in the use of complementary alternative medicine (CAM) as a cost-effective way to manage chronic pain. The present program was initiated to assess the effects of Hatha
Young, Constance M.
core  

Assessment of chronic postsurgical pain after knee replacement : a systematic review [PDF]

, 2013
Objective: Approximately 20% of patients experience chronic pain after total knee replacement (TKR), yet there is no consensus about how best to assess such pain.
Rachael Gooberman‐Hill, Karen Elvers, Vikki Wylde, Wylde, Vikki, Beswick, Andrew, Elvers, Karen, Julie Bruce, Gooberman-Hill, Rachael, Bruce, Julie, Andrew Beswick, Bruce, J. (Julie)   +10 more
core   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source