Results 51 to 60 of about 1,724,334 (359)

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova, Teresa Fazia, Giovanni Di Caprio, Davide Gentilini, Luisa Bernardinelli, Roberto Bergamaschi   +5 more
wiley   +1 more source

Distress as a mediator for pain and activities of daily living in older adults with fibromyalgia

Frontiers in Medicine, 2022
IntroductionPain, distress, and activities of daily living impact the lives of those with chronic pain. This study investigated distress (depressive symptoms, anxiety) on the relationship between pain (intensity and pain interference) and activities of ...
Caitlin Gower, Caitlin Gower, Jennifer Trevitt, Jennifer Trevitt, Barbara J. Cherry, Barbara J. Cherry, Barbara J. Cherry, Laura Zettel-Watson, Laura Zettel-Watson, Laura Zettel-Watson   +9 more
doaj   +1 more source

Lack of evidence for central sensitization in idiopathic, non-traumatic neck pain : a systematic review [PDF]

, 2015
Background: Chronic neck pain is a common problem with a poorly understood pathophysiology. Often no underlying structural pathology can be found and radiological imaging findings are more related to age than to a patient's symptoms.
Bramer, Wichor, Cagnie, Barbara, Danneels, Lieven, Dolphens, Mieke, Kregel, Jeroen, Kuipers, Mandy, Malfliet, Anneleen, Meeus, Mira, Nijs, Jo, Roussel, Nathalie   +9 more
core   +1 more source

Chronic non-specific low back pain - sub-groups or a single mechanism? [PDF]

, 2008
Copyright 2008 Wand and O'Connell; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use ...
A Antal, A Antal, A Delitto, A Keller, A Moore, A Pascual-Leone, A Radebold, A Radebold, A Rosner, A Schrag, AF Bendix, AF Mannion, AF Molsberger, AH McGregor, AJ Harris, AV Apkarian, AV Apkarian, AWM Evers, B Kainz, B Schweikert, Benedict Martin Wand, BF Walker, BW Koes, BW Koes, C Eccleston, C Larivie're, C Leboeuf-Yde, C Leboeuf-Yde, C Maihöfner, C Maihöfner, C Richardson, C Schmahl, C Young-Casey, CJ Hsieh, CJ Lamoth, CJ Main, CJ Main, CJ McCarthy, CJ McCarthy, CPN Watson, CS McCabe, CS McCabe, D Turk, DA Seminowicz, DC Turk, DG Wilder, DI Cook, DJ Clauw, DJ Critchley, DL Riddle, DM Small, EE Bostan, EH Kääpä, EI Skargren, EJ Carragee, EJ Carragee, EL Hurwitz, EL Hurwitz, EM Hay, EM Wassermann, F Fregni, F Keefe, F Kleinstück, FJ Keefe, G Bronfort, G Jull, G Waddell, GA Koumantakis, GE Bekkering, GE Hicks, GL Moseley, GL Moseley, GL Moseley, GL Moseley, GL Moseley, GL Moseley, GR Fink, H Flor, H Flor, H Flor, H Flor, H Flor, H Flor, H Frost, H Merskey, HJM Van Den Hoogen, ID Grachev, ID Grachev, ID Grachev, J Lorenz, J McCarthy, J Pells, JA Hayden, JA Hayden, JD Childs, JE Cassisi, JG Klein, JH Van Dieën, JL Carr, JL Porter, JM Fritz, JM Whitman, JS Lewis, JWS Vlaeyen, JWS Vlaeyen, KJ Petrie, KP Barr, KP Gill, L Klenerman, L Niemistö, L Vogt, LA Smith, LHM Pengel, LM McCracken, LM Smedstad, M Adams, M Jeannerod, M Leeuw, M Riipinen, M Van Der Hulst, M Van Tulder, M Yeh, MA Rogers, MC Cairns, MD Freeman, MD Grabiner, ME Geisser, MIV Mientjes, MN Baliki, MR Underwood, MS George, MW van Tulder, MW van Tulder, N Bogduk, N Bogduk, N Jousset, N Maniadakis, N Nies, Neil Edward O'Connell, NJ Zimny, NW Mok, P Dolan, P Jellema, P Kent, P Michaelson, P O'Sullivan, PB Fitzgerald, PB O'Sullivan, PB O'Sullivan, PH Canter, PH Ferreira, PJ Siddall, PJ Watson, PM Kent, R Andenaes, R Herbert, R Waxman, RA Deyo, RA McKenzie, RC de Charms, RJEM Smeets, RW Ostelo, RW Selles, S Brumagne, S Luoto, S Luoto, S Luoto, S Taimela, S Taimela, S Thompson, S Yusuf, SA Ferguson, SJ Linton, SJ Linton, SM Ott, T Bendix, T Flynn, T Giesecke, T Giesecke, T Honda, T Hyphantis, T Petersen, T Peterson, T Pincus, T Pincus, T Schmidt-Wilcke, The UK BEAM Trial Team, TS Carey, TZ Kincses, V Leinonen, VS Ramachandran, W Dankaerts, WJJ Assendelft, WO Spitzer, WS Marras, WS Marras, WS Marras, WS Marras, WS Marras   +198 more
core   +4 more sources

Remaining Burden of Spinal Muscular Atrophy Among Treated Patients: A Survey of Patients and Caregivers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinal muscular atrophy (SMA) significantly impacts motor function. This study aimed to assess the persistent burden and unmet needs among currently treated patients with SMA and their caregivers. Methods Two complementary web‐based surveys were distributed in August 2024 among patients with SMA and their caregivers.
Julie A. Parsons, Natalie Land, Melissa Culhane Maravic, Claire Cagle, Amal Jamaleddine, Hemal Shah, Thomas Brown, Christabella Cherubino, Mouhamed Gueye   +8 more
wiley   +1 more source

Green Light Exposure Reduces Primary Hyperalgesia and Proinflammatory Cytokines in a Rodent Model of Knee Osteoarthritis: Shedding Light on Sex Differences

Biomedicines
Knee osteoarthritis (OA) often causes chronic pain that disproportionately affects females. Proinflammatory cytokines TNF-α, IL-1β, and IL-6 are key effectors of OA pathological changes.
Laura Ventura, Renan F. do Espírito-Santo, Michael Keaser, Youping Zhang, Jin Y. Ro, Joyce T. Da Silva   +5 more
doaj   +1 more source

Prevalence of chronic pain in Libya before and after the uprising of 17 February 2011. [PDF]

, 2013
Two questionnaires were translated into Arabic and culturally adapted to measure chronic pain and neuropathic pain in the general population in Derna, Libya (1, 2), and then in a country-wide survey.
Tashani, OA
core   +2 more sources

Discovery and Treatment of Action Potential‐Independent Myotonia in Hyperkalemic Periodic Paralysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hyperkalemic periodic paralysis (hyperKPP) is characterized by attacks of transient weakness. A subset of hyperKPP patients suffers from transient involuntary contraction of muscle (myotonia). The goal of this study was to determine mechanisms causing myotonia in hyperKPP.
Chris Dupont, Adam Deardorff, Murad Nawaz, Andrew A. Voss, Mark M. Rich   +4 more
wiley   +1 more source

Altered network architecture of functional brain communities in chronic nociplastic pain

NeuroImage, 2021
Neuroimaging has enhanced our understanding of the neural correlates of pain. Yet, how neural circuits interact and contribute to persistent pain remain largely unknown.
Tony E. Larkin, Chelsea M. Kaplan, Andrew Schrepf, Eric Ichesco, Ishtiaq Mawla, Steven E. Harte, George A. Mashour, Daniel J. Clauw, Richard E. Harris   +8 more
doaj   +1 more source

Digital Activity Markers in Chronic Inflammatory Demyelinating Polyneuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the utility of smartwatch and smartphone‐based activity metrics for assessing disease severity and quality of life in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Methods In the electronic monitoring of disease activity in patients with CIDP (EMDA‐CIDP) trial, we performed a prospective ...
Lars Masanneck, Jan Voth, Noëmi Gmahl, Konstantin Jendretzky, Niklas Huntemann, Noah M. Werner, Linea Schmidt, Menekse Oeztuerk, Paula Quint, Christina B. Schroeter, Hans Peter Hartung, Thomas Skripuletz, Gerd Meyer zu Hörste, Tobias Ruck, Sven G. Meuth, Marc Pawlitzki   +15 more
wiley   +1 more source