Results 171 to 180 of about 1,680,702 (240)

Clinical use of sodium bicarbonate in small animals: indications, electrolyte changes and survival outcome

Journal of Small Animal Practice, EarlyView.
Objectives The objective of the study was to describe the use of sodium bicarbonate in dogs and cats. Materials and Methods Retrospective descriptive study of animals administered sodium bicarbonate from 2019 to 2023 in a university teaching hospital.
L. Hoover, M. A. Oyama, E. L. Reineke
wiley   +1 more source

GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms

Obesity Reviews, EarlyView.
ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani, Tzu‐Wen L. Cross, Erica de Jong, Emily S. Glover, Ivan D. Mendoza, Mojisola Adisa, Keigo Tomoo, Xinyi Zhou, Richard D. Mattes   +8 more
wiley   +1 more source

Rethinking Global Obesity Guidelines: Integrating Evidence, Equity and Precision (2014–2026)

Obesity Reviews, EarlyView.
Challenges and evidence in obesity guidelines. ABSTRACT Obesity remains a global health crisis characterized by substantial heterogeneity in diagnosis, management, and policy implementation. Although numerous national and international clinical practice guidelines have been published over the past decade, their translation into evidence‐based and ...
Rosero‐Revelo Ricardo, Tamayo Mateo, Henao Diana, Juan P. Polanco, Cortés David, Juan C. Alba, Giha Valeria, Camargo Camilo, Hernández Eder, Correa Ricardo, Nassar Ricardo, Cabandugama Peminda, Marcio L. Griebeler, Burguera Bartolome   +13 more
wiley   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

R‐Loops Mediated Odontogenic Differentiation of hDPSCs by Activating the cGAS‐STING Pathway Under Inflammatory Microenvironment

Oral Diseases, EarlyView.
ABSTRACT Background R‐Loops are three‐stranded DNA/RNA hybrids implicated in immune responses. Their role in mesenchymal stem cell differentiation, particularly in dental pulp regeneration under inflammation, remains unclear. Methods Rat pulpo‐dentinal complex (PDC) injury models and LPS‐stimulated human dental pulp stem cells (hDPSCs) were used.
Yun Yang, Yiqing Wang, Yating Miao, Zhipu Luo, Lin Niu, Ruirui Liu   +5 more
wiley   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Codocytosis in the Dog: 345 Cases (2020–2022)

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Introduction Codocytes, or target cells, are a morphologic variation of erythrocytes characterized by increased membrane surface area relative to volume. In dogs, codocytosis is frequently noted on blood smear evaluation, but its clinical significance remains poorly understood. Objectives To characterize the clinical conditions associated with
Sarena M. Krojanker, Maria Jaramillo, Brad D. Cingolani, Floyd L. Williams Jr., Priscila B. S. Serpa, Andrew D. Woolcock   +5 more
wiley   +1 more source

Kinetics of Regenerating Protein 3E and C‐Reactive Protein in Healthy Dogs, Dogs Undergoing Tibial Plateau Leveling Osteotomy, and Dogs With Sepsis

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Background Serial measurements of acute‐phase proteins help monitor the development of and recovery from sepsis in people and dogs. To date, the kinetics of regenerating protein (REG) 3E, a novel biomarker for inflammation in dogs, are unknown.
Laura Gentilini, Johanna Rompf, Judith Howard, Simone Schuller, Laureen M. Peters   +4 more
wiley   +1 more source

Cytologic, Clinicopathologic, and Histologic Findings in a Dog with a Gallbladder Neuroendocrine Carcinoma and Multiple Endocrinopathies

Veterinary Clinical Pathology, EarlyView.
ABSTRACT A 10‐year‐old spayed female Shih Tzu was evaluated for a gallbladder mass incidentally identified during a diagnostic workup for hyperadrenocorticism and persistent hypercalcemia. Diagnostic imaging revealed a vascularized intraluminal gallbladder mass, and cytologic examination showed cohesive clusters of epithelial cells with distinct ...
Sam Wicker, Alexis Johnson, Shelly Olin, Thomas Bevelock, Constance Fazio, Hiroyuki Mochizuki   +5 more
wiley   +1 more source