Results 281 to 290 of about 155,160 (352)

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 916-927, April 2026.
Thiopurine methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) are key enzymes that catabolize thiopurines. Decreased or no‐function alleles in TPMT and NUDT15 are associated with reduced or no enzyme activity and predictive of pronounced adverse effects, including severe myelosuppression, that may occur among individuals treated with standard ...
Maud Maillard, Matthias Schwab, Michelle Whirl‐Carrillo, Ann M. Moyer, Guilherme Suarez‐Kurtz, Ching‐Hon Pui, C. Michael Stein, Teri E. Klein, Claire Spahn, Sooyeon Kwon, Juanda Leo Hartono, Nanne K. de Boer, Tariq Ahmad, Federico Guillermo Antillon‐Klussmann, Kelly E. Caudle, Motohiro Kato, Allen E. J. Yeoh, Kjeld Schmiegelow, Jun J. Yang   +18 more
wiley   +1 more source

Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview. [PDF]

Front Physiol
Lin Z, Pandol S, Apte M, Jiang Y.
europepmc   +1 more source

Medical tactics for chronic pancreatitis: some features of patient management during outpatient follow-up

D. O. Hontsariuk, V. O. Zapotochna, O. O. Horbachova   +2 more
openalex   +2 more sources

Endoscopic management of acute cholecystitis in high‐risk surgical patients: A comprehensive review article

DEN Open, Volume 6, Issue 1, April 2026.
Abstract Acute cholecystitis is frequently encountered in daily clinical practice, and early cholecystectomy is the standard therapy. In high‐risk surgical patients, such as those with advanced age, deteriorated performance status, or underlying diseases, conservative treatment is typically preferred to manage acute cholecystitis.
Akinori Maruta, Takuji Iwashita, Kensaku Yoshida, Shogo Shimizu, Masahito Shimizu   +4 more
wiley   +1 more source

Targeted inhibition of M2 macrophages polarization via a PDC attenuates chronic pancreatitis through the PPARα pathway. [PDF]

iScience
Kong X, Tao X, Xiang H, Guo F, Wu Y, Lv J, Zhao X, Zhang X, Zhai Z, Dong D.   +9 more
europepmc   +1 more source

Covered Self‐Expanding Metal Stents Versus Multiple Plastic Stents in Treating Biliary Strictures Post‐Orthotopic Liver Transplantation: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives Anastomotic biliary strictures are a common complication following orthotopic liver transplantation (post‐OLT), impacting morbidity and graft survival. This meta‐analysis evaluates the efficacy, safety, and cost‐effectiveness of covered self‐expanding metal stents (cSEMS) versus multiple plastic stents (MPS) for treating post‐OLT ...
Ygor Rocha Fernandes, Thiago Arantes de Carvalho Visconti, Marcelo Klotz Dall'Agnol, André Orsini Ardengh, Matheus de Oliveira Veras, Evellin Souza dos Santos Valentim, Marcos Eduardo Lera dos Santos, Sergio Eiji Matuguma, Wanderley Marques Bernardo, Eduardo Guimarães Hourneaux de Moura   +9 more
wiley   +1 more source

Incretin system and glucagon secretion in patients with chronic pancreatitis. [PDF]

Eur J Clin Invest
Ciccarelli G, Di Giuseppe G, Gliozzo G, Soldovieri L, Quero G, Nista EC, Brunetti M, Cinti F, De Lucia SS, Hartmann B, Mari A, Gasbarrini A, Alfieri S, Pontecorvi A, Juul Holst J, Giaccari A, Mezza T.   +16 more
europepmc   +1 more source

Prevention of Adverse Events in Endoscopic Ultrasound‐Guided Biliary Drainage

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Endoscopic ultrasound‐guided biliary drainage (EUS‐BD) is used when biliary drainage using endoscopic retrograde cholangiopancreatography fails. Recently, it has been adopted as a primary biliary drainage method, and its indications have expanded.
Hirotoshi Ishiwatari, Hiroki Sakamoto, Takuya Doi, Masahiro Yamamura   +3 more
wiley   +1 more source

Mortality and cancer risk in patients with chronic pancreatitis in japan: insights into the importance of surveillance for pancreatic cancer. [PDF]

J Gastroenterol
Matsumoto R, Kikuta K, Takikawa T, Nakai Y, Takenaka M, Oki K, Ohno E, Ito K, Fujimori N, Katanuma A, Masuda A, Hori Y, Ikeura T, Suzuki R, Yamamoto S, Sogame Y, Kawashima H, Ito T, Okuwaki K, Itoi T, Takayama Y, Nakamura A, Terai S, Matsumoto K, Kuwatani M, Kishiwada M, Shigekawa M, Matsumori T, Inatomi O, Hatta W, Irisawa A, Unno M, Takeyama Y, Masamune A, Japan Pancreatitis Study Group for Chronic Pancreatitis.   +34 more
europepmc   +1 more source

Wirsungocele as a Rare Cause of Recurrent Pancreatitis: Etiology and Therapeutic Insights

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Wirsungocele, a cystic dilation at the end of the main pancreatic duct, is associated with recurrent acute pancreatitis. A 52‐year‐old man presented to our hospital with recurrent epigastric pain over an 8‐month period with a history of multiple medical visits for the same complaint.
Sorano Ichiya, Jun Nakahodo, Shunsuke Imaeda, Ryogo Minami, Fumio Kakizaki, Wataru Ujita, Hiroki Tabata, Kazuro Chiba, Toshiro Iizuka   +8 more
wiley   +1 more source