Results 101 to 110 of about 83,612 (338)

Adipose Tissue Macrophages as Initiators of Exacerbated Periodontitis in Estrogen‐Deficient Environments via the Amplifier Extracellular Vesicles

Advanced Science, EarlyView.
Chronic systemic inflammation, worsened by estrogen deficiency, underlies and exacerbates periodontitis. Proinflammatory macrophages within visceral adipose tissue are hyperactivated due to hyper‐DNA methylation, releasing small extracellular vesicles (sEVs) similar to those of their parent cells.
Danfeng Li, Tian Yang, Yuqian Li, Xinwei Lyu, Cheng Hu, Jiayin Yan, Jiali Tan   +6 more
wiley   +1 more source

Detection of Granulocyte Chemotactic Protein 2 in Serum of Periodontitis Patients

Journal of Baghdad College of Dentistry, 2016
Background: Chronic periodontitis defined as “an infectious inflammatory disease within supporting tissues of the teeth, progressive attachment loss and bone loss".
Saja GH. Hussien, Basima Gh. Ali
doaj   +1 more source

General immune status and oral microbiology in patients with different forms of periodontitis and healthy control subjects. [PDF]

PLoS ONE, 2014
OBJECTIVE: Immunological processes in the etiopathogenesis of periodontitis, especially the aggressive form, are not well understood. This study examined clinical as well as systemic immunological and local microbiological features in healthy controls ...
Jana Schmidt, Holger Jentsch, Catalina-Suzana Stingu, Ulrich Sack   +3 more
doaj   +1 more source

Active invasion of Porphyromonas gingivalis and infection-induced complement activation in ApoE-/- mice brains [PDF]

, 2014
Periodontal disease is a polymicrobial inflammatory disease that leads to chronic systemic inflammation and direct infiltration of bacteria/bacterial components, which may contribute to the development of Alzheimer’s disease.
Chukkapalli, Sasanka, Crean, Stjohn, Kesavalu, Lakshmyya, Poole, Sophie, Rivera, Mercedes, Singhrao, Simarjit Kaur, Velsko, Irina   +6 more
core   +1 more source

Mitochondria‐Targeted ROS Scavenging Natural Enzyme Cascade Nanogels for Periodontitis Treatment via Hypoxia Alleviation and Immunomodulation

Advanced Science, EarlyView.
TPP‐SAT, a mitochondria‐targeted natural enzyme‐cascade nanogel, selectively scavenges mitochondrial ROS (e.g., H2O2/·O2⁻) and converts them into therapeutic O2 via enzymatic cascades, alleviating hypoxia and inflammation. It rebalances M1/M2 macrophage polarization, activates the Nrf2 pathway while suppressing NF‐κB, enhances antioxidant defenses, and
Yanfen Zheng, Liuzhou Mao, Qi Wang, Haohua Hu, Bahriman Xarpidin, Zheng Luo, Yun‐Long Wu   +6 more
wiley   +1 more source

Study of the patterns of periodontal destruction in smokers with chronic periodontitis

Indian Journal of Dental Research, 2008
Cigarette smoking is a well-established risk factor for periodontitis and carries an increased risk for loss of periodontal attachment as well as for bone loss.The purpose of the study was to investigate the pattern of the intraoral distribution of periodontal destruction among cigarette smokers with periodontitis by assessing the periodontal probing ...
openaire   +4 more sources

AI‐Enhanced Surface‐Enhanced Raman Scattering for Accurate and Sensitive Biomedical Sensing

Advanced Intelligent Discovery, EarlyView.
AI‐SERS advances spectral interpretation with greater precision and speed, enhancing molecular detection, biomedical analysis, and imaging. This review explores its essential contributions to biofluid analysis, disease identification, therapeutic agent evaluation, and high‐resolution biomedical imaging, aiding diagnostic decision‐making.
Seungki Lee, Rowoon Park, Ho Sang Jung
wiley   +1 more source

Study on porphyromonas gingivalis- and porphyromonas endodontalis- mediated signaling pathway [PDF]

, 2019
It is known that anaerobic microbes like Porphyromonas gingivalis (P. gingivalis) are involved in the progression and initiation of multiple forms of periodontal disease such as chronic periodontitis.
Alamry, Nujud
core  

Can oral infection be a risk factor for Alzheimer’s disease? [PDF]

, 2015
Alzheimer’s disease (AD) is a scourge of longevity that will drain enormous resources from public health budgets in the future. Currently, there is no diagnostic biomarker and/or treatment for this most common form of dementia in humans.
Alzheimer A, Ball MJ, Bünzli D, Cicci[ugrave] M, Dunn N, Hachinsky V, Ingar Olsen, Kovács T, Lin WR, Miklossy J, Mori I, Oldfield BJ, Ouerfurth HW, Regitz C, Sim K. Singhrao, Song Y, Urovesic N, Whittum-Hudson JA   +17 more
core   +2 more sources

Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects

Animal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang, Yiming Liu, Dan Chen, Leiming Liu, Leimin Sun, Lingling Zhang   +5 more
wiley   +1 more source