Results 51 to 60 of about 1,712,061 (282)

Chronic Itch Affects Patients’ Ability to Experience Pleasure: Anhedonia in Itchy Disorders

Acta Dermato-Venereologica
Anhedonia, the reduced ability to experience pleasure, is a prevalent symptom in various psychiatric disorders, but has not been investigated in dermatological conditions, particularly those characterized by chronic itch.
Aleksandra Stefaniak, Magdalena Berek-Zamorska, Claudia Zeidler, Sonja Ständer, Jacek C. Szepietowski   +4 more
doaj   +1 more source

Validation of the Itch Severity Item as a Measurement Tool for Pruritus in Patients with Psoriasis: Results from a Phase 3 Tofacitinib Program

Acta Dermato-Venereologica, 2017
Tofacitinib is an oral Janus kinase inhibitor. This post-hoc analysis aimed to investigate the psychometric properties of the Itch Severity Item (ISI), a numeric rating scale from 0 (no itching) to 10 (worst possible itching) for pruritus in psoriasis ...
Sonja Ständer, Thomas Luger, Joseph C. Cappelleri, Andrew G. Bushmakin, Carla Mamolo, Michael A. Zielinski, Anna M Tallman, Gil Yosipovitch   +7 more
doaj   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Brachioradial Pruritus and Notalgia Paraesthetica: A Comparative Observational Study of Clinical Presentation and Morphological Pathologies

Acta Dermato-Venereologica, 2017
Brachioradial pruritus (BRP) and notalgia paraesthetica (NP) represent 2 of the most common neuropathic itch syndromes. A total of 58 consecutive patients presenting at the Center for Chronic Pruritus, University Hospital Münster, were analysed with ...
Manuel P. Pereira, Hannah Lüling, Annette Dieckhöfer, Sabine Steinke, Claudia Zeidler, Sonja Ständer   +5 more
doaj   +1 more source

Temporal‐Targeted Accelerated 40 Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial

Advanced Science, EarlyView.
Bilateral temporal accelerated 40‐Hz tACS improves cognitive function in patients with Alzheimer's disease. Resting‐state fNIRS identifies treatment‐related increases in frontotemporoparietal functional connectivity, which are associated with cognitive improvement. ABSTRACT The temporal lobes are key hubs for memory and cognition.
Rong Guo, Xingxing Li, Chenjun Zou, Chao Zheng, Xiaohong Wu, Xuechao Lu, Jiaying Yan, Junfang Zhang, Xiaoyan Luo, Shiwei Ye, Dongsheng Zhou   +10 more
wiley   +1 more source

Content Validity and Psychometric Validation of an Adapted Version of the Subject Sleep Diary in Prurigo Nodularis

Dermatology and Therapy
Introduction Patients with prurigo nodularis (PN) often experience sleep disturbance. A psychometric evaluation was conducted to assess the suitability of a PN-adapted multi-item subject sleep diary (SSD) for measuring PN-related sleep disturbance ...
Sonja Ständer, Danielle N. Rodriguez, Carla Dias-Barbosa, Dina Filipenko, Jorge Puelles, Zarif K. Jabbar-Lopez, Christophe Piketty, Henning Wiegmann, Shawn G. Kwatra   +8 more
doaj   +1 more source

Pruritus and the Quality of Life in Patients with Chronic Kidney Disease Stage VD Treated by Hemodialysis

, 2013
Introduction. The problem of the quality of life of patients with the chronic kidney disease stage VD treated by hemodialysis is becoming more and more urgent in medicine. One of the most common factors that worsen in patients with chronic kidney disease
Abrahamovych K., Abrahamovych O., Dudar I.   +2 more
core   +1 more source

Targeted‐Penetrating Biomimetic Hybrid Transfersomes for Enhanced Transdermal Gene Transfection in Hypertrophic Scar Therapy

Advanced Science, EarlyView.
Hypertrophic scar fibroblasts membrane‐hybridized cationic transfersomes enable efficient loading and transdermal delivery of TGF‐β1 siRNA through multiple skin penetration pathways. The biomimetic platform enhances homotypic targeting, transfection, and immune evasion, suppresses TGF‐β1‐driven fibrotic signaling, and reduces extracellular matrix ...
Hui Xing, Ziyi Zhao, Yuhui Yang, Yichen Lin, Yinglin Xuan, Ziyang Wang, Kai Lv, Xiaoxu Zhu, Zhi Zhang, Dong Ma   +9 more
wiley   +1 more source

Koebnerization of Hailey–Hailey disease into chronic prurigo nodularis: Clearance of both entities under a naloxone therapy

JEADV Clinical Practice
Hailey–Hailey disease (HHD) is a genetic skin disorder, accompanied by lesional pruritus and a relevant impact on quality of life of affected patients. Approved or even successful treatments are still lacking, highlighting the need for further insight in
Felix Witte, Dieter Metze, Sonja Ständer, Claudia Zeidler   +3 more
doaj   +1 more source

Chronic kidney disease-associated pruritus: features and associated factors

, 2021
Introduction: Chronic kidney disease (CKD) is a condition characterized by a gradual loss of kidney function over time due to injured kidneys or when the glomerular filtration rate is less than 60mL/min/1.73 m2, for more than three months.
Rana Khalid Obeed, Intisar Ahmed Hasan
core   +1 more source