Results 61 to 70 of about 47,991 (257)

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Selective Nerve Fibre Activation in Patients with Generalized Chronic Pruritus: Hint for Central Sensitization?

Acta Dermato-Venereologica, 2019
Central sensitization induces pain augmentation in chronic pain states. An analogous mechanism is speculated for chronic pruritus. This study compared patients with chronic pruritus (n = 79) of different origins (atopic dermatitis, chronic pruritus on ...
Manuel P. Pereira, Konstantin Agelopoulos, Johannes Köllner, Gitta Neufang, Martin Schmelz, Sonja Ständer   +5 more
doaj   +1 more source

Inflammatory Factors in Allergic Rhinitis: A 20‐Year Bibliometric Mapping and Emerging Trends

Flavour and Fragrance Journal, EarlyView.
This figure illustrates the bibliometric process and results of research on inflammatory factors of allergic rhinitis from 2004 to 2024 including data screening, global distribution, collaborative networks and the evolution of research hotspots. ABSTRACT Allergic rhinitis (AR) is driven by a network of inflammatory mediators released by mast cells ...
Shanshan Jing, Fengying Zhang, Qiqi Liu
wiley   +1 more source

Prevalence and Burden of Somatic Symptom Disorder in Atopic Dermatitis and Chronic Pruritus—The Persistent Somatic Symptoms Across Diseases: Pruritus (SOMA.PRU) Study

JEADV Clinical Practice
Background Somatic symptom disorder (SSD) is a relatively “novel” psychiatric diagnosis defined as excessive thoughts, feelings, or behaviors related to persistent somatic symptoms such as chronic pruritus (CP) and could be important in this population ...
Stefan M. Kahnert, Ansgar Koechel, Gina L. Frank, Svenja Royeck, Claudia Zeidler, Felix Witte, Christian Mess, Konstantin Agelopoulos, Volker Huck, Bernd Löwe, Rupert Conrad, Gudrun Schneider, Stefan W. Schneider, Sonja Ständer   +13 more
doaj   +1 more source

Monitoring and Mitigation Strategies for Hazardous Compounds in Chinese Rice Wine (Huangjiu): A Comprehensive Review

Food Safety and Health, EarlyView.
This review elucidates the formation pathways and detection technologies for ethyl carbamate, biogenic amines, and higher alcohols in Huangjiu. It concludes that integrated control frameworks are essential to decouple safety risks from the metabolic processes responsible for flavor development.
Lulu Liu, Zhiqiang Kong, Lin Li, Yifan Zhang, Bei Fan, Minmin Li   +5 more
wiley   +1 more source

"Electronic calculator of chronic pruritus": the first questionnaire for chronic pruritus evalution in the Ukrainian language

Journal of Education, Health and Sport, 2018
Andrashko Y. V., Yaremkevych R. R., Devinyak O. T., Zimenkovskyi A. A. “Electronic calculator of chronic pruritus”: the first questionnaire for chronic pruritus evalution in the Ukrainian language. Journal of Education, Health and Sport. 2018;8(1):414-429. eISSN 2391-8306.
Y. V. Andrashko, R. R. Yaremkevych, O. T. Devinyak, A. A. Zimenkovskyi   +3 more
openaire   +3 more sources

Management of Radiodermatitis in Patients With Head and Neck Cancer Undergoing Radiotherapy: A Scoping Review

Health Care Science, EarlyView.
The data obtained through this review highlight the lack of global consensus among radiotherapy centers on the best topical treatment for radiodermatitis. It indicates that the choice of treatment depends on professional judgment due to the absence of standardized guidelines, pointing to the need for more robust scientific research to develop effective
Tâmara Taynah Medeiros da Silva, Louise Constancia de Melo Alves Silva, Thatiane Evelyn de Lima Fernandes, Karena Cristina da Silva Leal, Thaís Brunna Maurício Pinheiro, Guilherme Moises Alves Fernandes, Kátia Regina Barros Ribeiro, Daniele Vieira Dantas, Rodrigo Assis Neves Dantas   +8 more
wiley   +1 more source

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

The Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi, Alessandra Ferro, Fabiana Cecere, Daniela Scattolin, Alessandro Del Conte, Alessandro Follador, Sara Pilotto, Valentina Polo, Mariacarmela Santarpia, Rita Chiari, Alberto Pavan, Alessandro Dal Maso, Valentina Da Ros, Giada Targato, Sabrina Vari, Stefano Indraccolo, Fiorella Calabrese, Stefano Frega, Laura Bonanno, Pier Franco Conte, Valentina Guarneri, Giulia Pasello   +21 more
wiley   +1 more source

Chronic Prurigo of Nodular Type: A Review

Acta Dermato-Venereologica, 2017
Prurigo nodularis (PN) is a subtype of chronic prurigo presenting single to multiple symmetrically distributed, hyperkeratotic and intensively itching papules and nodules.
Claudia Zeidler, Athanasios Tsianakas, Manuel Pereira, Hartmut Ständer, Gil Yosipovitch, Sonja Ständer   +5 more
doaj   +1 more source

Generalized chronic pruritus with fibromyalgia [PDF]

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2021
Max, Görg, Claudia, Zeidler, Manuel P, Pereira, Sonja, Ständer   +3 more
openaire   +2 more sources