Results 71 to 80 of about 3,957,405 (296)

A reversible system for chronic recordings in macaque monkeys [PDF]

Journal of Neuroscience Methods, 1997
We propose a system for head fixation and neuronal recording that minimizes surgery for implantation. Fixation is obtained by posts which are attached to the opposite sides of the skull and are connected by a rigid frame around the animal's head. As forces are counterbalanced and distributed around the head, the system does not need to be implanted ...
Pigarev, I., Nothdurft, H., Kastner, S.
openaire   +3 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Melatonin improves quality and longevity of chronic neural recording.

Biomaterials, 2018
The chronic performance of implantable neural electrodes is hindered by inflammatory brain tissue responses, including microglia activation, glial scarring, and neuronal loss.
Asiyeh Golabchi, Bingchen Wu, Xia Li, D. Carlisle, Takashi D. Y. Kozai, R. Friedlander, X. Cui   +6 more
semanticscholar   +1 more source

Minocycline increases quality and longevity of chronic neural recordings [PDF]

Journal of Neural Engineering, 2007
Brain/machine interfaces could potentially be used in the treatment of a host of neurological disorders ranging from paralysis to sensory deficits. Insertion of chronic micro-electrode arrays into neural tissue initiates a host of immunological responses, which typically leads to the formation of a cellular sheath around the implant, resulting in the ...
R L, Rennaker, J, Miller, H, Tang, D A, Wilson   +3 more
openaire   +2 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Printable microscale interfaces for long-term peripheral nerve mapping and precision control

Nature Communications, 2020
Modulation of peripheral nervous system signalling has many applications in medicine, neurobiology and machine-man interfaces. Here the authors develop a microscale implantable device for chronic interfacing with a small diameter nerve, and show multi ...
Timothy M. Otchy, Christos Michas, Blaire Lee, Krithi Gopalan, Vidisha Nerurkar, Jeremy Gleick, Dawit Semu, Louis Darkwa, Bradley J. Holinski, Daniel J. Chew, Alice E. White, Timothy J. Gardner   +11 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Plasticity changes in forebrain activity and functional connectivity during neuropathic pain development in rats with sciatic spared nerve injury

Molecular Brain, 2018
Neuropathic pain is a major worldwide health problem. Although central sensitization has been reported in well-established neuropathic conditions, information on the acute brain activation patterns in response to peripheral nerve injury is lacking.
Tzu-Hao Harry Chao, Jyh-Horng Chen, Chen-Tung Yen   +2 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Reimplantable Microdrive for Long-Term Chronic Extracellular Recordings in Freely Moving Rats

Frontiers in Neuroscience, 2019
Extracellular recordings of electrical activity in freely moving rats are fundamental to understand brain function in health and disease. Such recordings require a small-size, lightweight device that includes movable electrodes (microdrive) to record ...
Leopoldo Emmanuel Polo-Castillo, Leopoldo Emmanuel Polo-Castillo, Miguel Villavicencio, Leticia Ramírez-Lugo, Elizabeth Illescas-Huerta, Mario Gil Moreno, Leopoldo Ruiz-Huerta, Leopoldo Ruiz-Huerta, Ranier Gutierrez, Francisco Sotres-Bayon, Alberto Caballero-Ruiz, Alberto Caballero-Ruiz   +11 more
doaj   +1 more source