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Current Opinion in Immunology, 1994
Although chronic rejection remains the most crucial cause of organ graft loss over the long term, its etiology is not well defined. Early injury to graft endothelial cells caused by alloantigen-independent factors, such as ischemia or reperfusion, as well as alloantigen-dependent events, such as acute rejection, have been implicated.
H. Azuma, Nicholas L. Tilney
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Although chronic rejection remains the most crucial cause of organ graft loss over the long term, its etiology is not well defined. Early injury to graft endothelial cells caused by alloantigen-independent factors, such as ischemia or reperfusion, as well as alloantigen-dependent events, such as acute rejection, have been implicated.
H. Azuma, Nicholas L. Tilney
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Seminars in Nephrology, 2001
The major histocompatibility complex molecules are the primary antigens responsible for causing graft rejection, and T-cell recognition of alloantigens is the cardinal event initiating cellular rejection. Current concepts suggest that direct allorecognition mediates acute rejection, whereas indirect allorecognition mediates chronic rejection. In biopsy
Lea Emmett, Amir Tejani
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The major histocompatibility complex molecules are the primary antigens responsible for causing graft rejection, and T-cell recognition of alloantigens is the cardinal event initiating cellular rejection. Current concepts suggest that direct allorecognition mediates acute rejection, whereas indirect allorecognition mediates chronic rejection. In biopsy
Lea Emmett, Amir Tejani
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Mechanisms of chronic rejection
Current Opinion in Immunology, 2000Chronic rejection remains the major obstacle to long-term allograft survival. Detailed understanding of putative etiologic risk factors, both antigen-dependent and -independent, is important for designing effective therapeutic strategies to ameliorate this process. Cell senescence may be an important factor in chronic rejection.
Nicholas L. Tilney +3 more
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Chronic Rejection in the Heart
2006The dramatic improvements in 1-yr survival following cardiac transplantation have not been matched by similar improvements in long-term graft survival. Long-term survival of allografted hearts is limited by a progressive fibroproliferative disease, resulting in intimal thickening and occlusion of the grafted coronary vessels.
Marlene L. Rose, Philip Hornick
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Lymphoid neogenesis in chronic rejection
Current Opinion in Organ Transplantation, 2008Although chronic rejection is currently one of the main causes of long-term allograft failure, its pathogenesis remains elusive, thereby preventing the development of effective therapy.Recent advances in the comprehension of the pathophysiology of chronic inflammatory diseases could shed new light on the pathogenesis of chronic rejection.
Antonino Nicoletti, Olivier Thaunat
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Chronic Renal Transplant Rejection
American Journal of Kidney Diseases, 1994The most common cause of renal allograft failure, after the first year posttransplant, is chronic rejection (CR). The impact on allograft loss of CR has remained constant despite the improvements in immunosuppression that have occurred. This process is characterized by a gradual decline in graft function over months to years.
S. Ted Shaikewitz, Laurence Chan
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CHRONIC REJECTION OF THE LIVER ALLOGRAFT
Gastroenterology Clinics of North America, 1993Chronic rejection remains one of the major problems in the management of liver transplant recipients. Histologic diagnosis is central to the management of this condition. It remains difficult to predict cases that will progress toward irreversible rejection, because there are no early diagnostic features.
Stefan G. Hubscher +2 more
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Modulators of Chronic Rejection
1993Chronic rejection is one of the major threats of graft function on a long-term basis in heart and kidney transplantation.During the last decades, the results of organ transplantation have improved steadily, whereas the annual rate of graft loss after the first post-transplantation year has not changed significantly (Cook and Terasaki, 1989; Thorogood ...
Erik Larsson, Bengt Fellström
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Pathology of Chronic Rejection
1984In the 15 years since the first human heart transplant was performed by Barnard in 19671, there has been significant progress in establishing this procedure as an acceptable method of treating irremediable cardiac failure. Survival times have progressively improved2.
C. J. Uys, A. G. Rose
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Histopathology of chronic rejection
1997Chronic rejection remains a major cause of transplant organ loss [1–5]. Chronic rejection, characterized by end–organ ischemic atrophy and infarction secondary to vascular insufficiency (fibroproliferative/obliterative endarteritis), plays a prime role in cardiac, hepatic, renal and pancreatic allograft loss.
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