Results 241 to 250 of about 1,092,122 (354)

ON THE MECHANISM OF ACIDOSIS IN CHRONIC RENAL DISEASE* [PDF]

Journal of Clinical Investigation, 1959
W B, SCHWARTZ, P W, HALL, R M, HAYS, A S, RELMAN   +3 more
openaire   +2 more sources

Inhibiting Liver‐Derived C3 Protein Rescues Anesthesia/Surgery‐Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis

Advanced Science, EarlyView.
This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu, Peilin Cong, Zhouxiang Li, Yuxin Zhang, Huanghui Wu, Qian Zhang, Yawei Li, Li Tian, Qingyuan Miao, Yinggang Zheng, Hui Zhang, Qian Chen, Enduo Feng, Xinyang Li, Zheping Chen, Dong‐Xin Wang, Xinwei Huang, Lize Xiong   +17 more
wiley   +1 more source

Echocardiographic Assessment of Right Ventricular Systolic Function in Patients with Chronic Renal Disease.

J Cardiovasc Echogr
Abuelfotoh AE, Kassem HK, Alhefnawy SB, Elbarbary M.   +3 more
europepmc   +1 more source

Triglycerides to High-Density Lipoprotein Cholesterol Ratio Predicts Chronic Renal Disease in Patients without Diabetes Mellitus (STELLA Study). [PDF]

J Cardiovasc Dev Dis, 2020
Raikou VD, Kyriaki D, Gavriil S.
europepmc   +1 more source

Epigenetic Targeting of Senescent Cells Prevents the Deleterious Effects of Obstructive Sleep Apnea on Growing Skeleton

Advanced Science, EarlyView.
Chronic intermittent hypoxia induces premature senescence of osteoprogenitor cells in long bone metaphysis via HIF1α‐mediated EZH2‐H3k27me3 downregulation, leading to impaired bone growth. Restoration of H3K27me3 level via UTX inhibition rescues osteogenesis and growth impairment in young mice.
Xiaonan Liu, Peilin Zhang, Zhongyi Su, Yong Feng, Zhenger Zhou, Sa Pang, Yicheng Wang, Jiacheng Hu   +7 more
wiley   +1 more source

Obesity and bariatric intervention in patients with chronic renal disease. [PDF]

J Int Med Res, 2019
Bellini MI, Paoletti F, Herbert PE.
europepmc   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Expert consensus on the diagnosis and management of diabetic kidney disease

Chinese Medical Journal, 2020
Xiu-Yuan Hao, Xin Chen, Diabetic Kidney Disease Cooperative Group of Peking University Health Science Center   +2 more
doaj   +1 more source

FP314A RISK SCORING MODEL TO PREDICT RENAL PROGRESSION IN CHRONIC KIDNEY DISEASE PATIENTS WITH CONTRAST INDUCED NEPHROPATHY [PDF]

, 2018
Seung Don Baek, Mun Jang, Won-Hak Kim, Eun Kyoung Lee, So Mi Kim, Jai Won Chang   +5 more
openalex   +1 more source

Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury

Advanced Science, EarlyView.
By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou, Fan Fan Hou, Haiyan Fu, Youhua Liu   +14 more
wiley   +1 more source