Results 1 to 10 of about 149,546 (225)
Relapses or de-novo IgA nephropathy following COVID-19 vaccination; a narrative review [PDF]
Journal of Nephropathology, 2023 Immunoglobulin A (IgA) nephropathy is the most common type of glomerulonephritis worldwide characterized by excessive serum levels of glycosylated which triggers the generation of glycan-specific IgG and IgA autoantibodies.
Masoud Hafizi +5 more
doaj +3 more sources
Sarsasapogenin Preserves Podocyte Integrity and Attenuates Renal Injury in Experimental IgA Nephropathy. [PDF]
FASEB JExperimental IgA nephropathy leads to renal inflammation, fibrosis, podocyte injury, and impaired renal function. Sarsasapogenin treatment attenuated inflammatory and profibrotic signaling, reduced extracellular matrix accumulation, preserved nephrin and podocin expression, improved podocyte ultrastructure, and ameliorated renal histopathological ...
Kumaş M +7 more
europepmc +2 more sources
Urinary IL-18 predicts progression of IgA nephropathy [PDF]
BMC NephrologyBackground There is currently a lack of noninvasive biomarkers that effectively predict the progression of IgA nephropathy. We investigated the value of urinary IL-18 in predicting the progression of IgA nephropathy and whether its combination with ...
Yuhong Tang +8 more
doaj +2 more sources
KM55 in the evaluation of IgA containing glomerular diseases
Glomerular Diseases, 2021 Introduction: Mucosal derived galactose deficient IgA is central to the pathogenesis of primary IgA nephropathy. Recent reports suggest similar pathogenesis in Henoch Schonlein purpura and secondary IgA nephropathy.
Rahul Raj +7 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Background: Aberrant O-glycosylation of IgA1 plays an important role in IgA nephropathy pathogenesis. Previous proteomic studies analyzed O-glycans of the circulating IgA1 hinge region and found that the N-acetylgalactosamine (GalNAc) and galactose ...
Shuyu Zhang +8 more
doaj +1 more source
International Journal of Pediatrics, 2023 Objectives. This review addresses the microscopic features of immunoglobulin A nephropathy (IgA nephropathy), its prognostic variables in children, and measures to which extent these features and variables differ from adults.
Reem A. Al Zahrani
doaj +1 more source
COVID-19 Hyperinflammation: What about Neutrophils?
mSphere, 2020 COVID-19 is often related to hyperinflammation that drives lung or multiorgan injury. The immunopathological mechanisms that cause excessive inflammation are under investigation and constantly updated.
Athanasios Didangelos
doaj +1 more source
Urinary exosomal miRNA signature of IgA nephropathy: a case–control study
Scientific Reports, 2023 IgA nephropathy is the most common primary glomerulonephritis worldwide and can progress to end-stage kidney disease (ESKD). The current “gold standard” for diagnosis is kidney biopsy, which is invasive and associated with morbidity.
Mythri Shankar +5 more
doaj +1 more source
Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathy. [PDF]
PLoS ONE, 2018 IgA nephropathy is an autoimmune disease characterized by IgA1-containing glomerular immune deposits. We previously proposed a multi-hit pathogenesis model in which patients with IgA nephropathy have elevated levels of circulatory IgA1 with some O ...
William J Placzek +8 more
doaj +1 more source
Frontiers in Immunology, 2023 Immunoglobulin A (IgA) nephropathy is a common autoimmune kidney disease. Accumulating studies showed that IgA nephropathy may be partially correlated with mucosal immune system dysfunction.
Jian Liao +9 more
doaj +1 more source