Results 1 to 10 of about 25,586 (182)
Nature Reviews Disease Primers, 2023 Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis in the world. The etiology is unknown but a dysregulated T-cell immune response to viral, bacterial, and food antigens activating mucosal plasma cells to produce polymeric IgA has been proposed. No serological test exists to diagnosis IgAN.
Vladimir Tesar +2 more
exaly +6 more sources
Nature Reviews Disease Primers, 2016 Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but current biochemical and genetic data implicate overproduction of aberrantly glycosylated IgA1.
Francesco Paolo Schena +2 more
exaly +9 more sources
Urinary IL-18 predicts progression of IgA nephropathy [PDF]
BMC NephrologyBackground There is currently a lack of noninvasive biomarkers that effectively predict the progression of IgA nephropathy. We investigated the value of urinary IL-18 in predicting the progression of IgA nephropathy and whether its combination with ...
Yuhong Tang +8 more
doaj +2 more sources
The Role of IgA in the Pathogenesis of IgA Nephropathy [PDF]
International Journal of Molecular Sciences, 2019 Immunoglobulin A (IgA) is the most abundant antibody isotype produced in humans, predominantly present in the mucosal areas where its main functions are the neutralization of toxins, prevention of microbial invasion across the mucosal epithelial barrier, and simultaneous maintenance of a physiologically indispensable symbiotic relationship with ...
Martina Perse, Željka Večerić-Haler
exaly +4 more sources
Relapses or de-novo IgA nephropathy following COVID-19 vaccination; a narrative review [PDF]
Journal of Nephropathology, 2023 Immunoglobulin A (IgA) nephropathy is the most common type of glomerulonephritis worldwide characterized by excessive serum levels of glycosylated which triggers the generation of glycan-specific IgG and IgA autoantibodies.
Masoud Hafizi +5 more
doaj +1 more source
KM55 in the evaluation of IgA containing glomerular diseases
Glomerular Diseases, 2021 Introduction: Mucosal derived galactose deficient IgA is central to the pathogenesis of primary IgA nephropathy. Recent reports suggest similar pathogenesis in Henoch Schonlein purpura and secondary IgA nephropathy.
Rahul Raj +7 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Background: Aberrant O-glycosylation of IgA1 plays an important role in IgA nephropathy pathogenesis. Previous proteomic studies analyzed O-glycans of the circulating IgA1 hinge region and found that the N-acetylgalactosamine (GalNAc) and galactose ...
Shuyu Zhang +8 more
doaj +1 more source
Clinical Journal of the American Society of Nephrology, 2017 IgA nephropathy (IgAN) is a leading cause of CKD and renal failure. Recent international collaborative efforts have led to important discoveries that have improved our understanding of some of the key steps involved in the immunopathogenesis of IgAN. Furthermore, establishment of multicenter networks has contributed to rigorous design and execution of ...
Jennifer C, Rodrigues +2 more
openaire +4 more sources
International Journal of Pediatrics, 2023 Objectives. This review addresses the microscopic features of immunoglobulin A nephropathy (IgA nephropathy), its prognostic variables in children, and measures to which extent these features and variables differ from adults.
Reem A. Al Zahrani
doaj +1 more source
COVID-19 Hyperinflammation: What about Neutrophils?
mSphere, 2020 COVID-19 is often related to hyperinflammation that drives lung or multiorgan injury. The immunopathological mechanisms that cause excessive inflammation are under investigation and constantly updated.
Athanasios Didangelos
doaj +1 more source