Results 41 to 50 of about 161,533 (212)
Sibeprenlimab, which neutralizes A PRoliferation Inducing Ligand (APRIL), as a new approach to treating IgA nephropathy [PDF]
Introduction Immunoglobulin A (IgA) nephropathy is a common immune-mediated kidney disease leading to high blood pressure and may progress to kidney failure. None of the present treatments are disease-modifying or prolong life.
Doggrell, Sheila A
core +1 more source
Steroid therapy is effective for IgA nephropathy after liver transplantation in a pediatric patient
Clinical Case Reports, 2021 Hepatic IgA nephropathy is a complication of chronic liver disease. IgA nephropathy after liver transplantation is rare, especially in children, and carries a significant risk factor for chronic renal failure and mortality.
Hiroshi Tamura +2 more
doaj +1 more source
Low incidence of IgA nephropathy in Blacks [PDF]
, 1985 Low incidence of IgA nephropathy in blacks. The clinical and pathologic features were evaluated in 106 IgA nephropathy patients identified in 1,753 consecutive patients undergoing renal biopsy in the southeastern United States. Special attention was paid
Jennette, J. Charles +2 more
core +1 more source
Immunoglobulin A-nephropathy: modern view of the problem and treatment options
Лечащий Врач, 2021 The presented review discusses the mechanisms of development, the issues of diagnosis and the possibility of therapy for IgAnephropathy. IgA-nephropathy is an immunocomplex lesion of the glomeruli, characterized by the predominant deposition of ...
I. T. Murkamilov +3 more
doaj +1 more source
The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy
Frontiers in Immunology, 2019 IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is necessary for diagnosis, with routine immunofluorescence microscopy revealing dominant ...
Dana V. Rizk +7 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective CASTOR1 senses arginine and regulates mammalian target of rapamycin complex 1 (mTORC1), a central metabolic signaling molecule. This study aimed to elucidate the roles of CASTOR1 in humoral immune responses. Methods We analyzed human B cell transcriptomes from healthy controls and patients with systemic lupus erythematosus (SLE) via ...
Takeshi Kusuda +5 more
wiley +1 more source
Kidney & Blood Pressure Research, 2014 Background/Aims: Our aim was to explore the molecular mechanism underlying development of IgA nephropathy and discover candidate agents for IgA nephropathy.
Jinling Wang, Juan Cao
doaj +1 more source
Possible Link between IgA Nephropathy and B-cell Acute Lymphoblastic Leukemia
Turkish Journal of Nephrology, 2020 IgA nephropathy (IgA-N) is the most common glomerulonephritis type globally. IgA-N is usually accepted as a kidney disease; however, IgA-N has been reported with infections, autoimmune diseases, and malignancies in the literature.
Eray Eroğlu +7 more
doaj +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Tissue‐resident memory T (TRM) cells have been implicated in organ‐specific immune pathology; however, the pathological relevance of TRM‐like CD8+ T cells in systemic lupus erythematosus (SLE) remains unclear. We investigated their differentiation mechanisms and pathological significance in SLE, including associations with disease activity ...
Yuya Fujita +10 more
wiley +1 more source
IgA nephropathy presenting with pulmonary thromboembolism and renal artery infarct [PDF]
, 2019 Background: Venous and arterial thromboembolism are frequently seen in nephrotic syndrome. They generally occur during periods of sustained proteinuria in patients who are not responding to treatment and more commonly seen in minimal change disease and ...
Anil Mathew +6 more
core +2 more sources