Results 41 to 50 of about 31,703 (224)

The Pathophysiology of IgA Nephropathy [PDF]

Journal of the American Society of Nephrology, 2011
Here we discuss recent advances in understanding the biochemical, immunologic, and genetic pathogenesis of IgA nephropathy, the most common primary glomerulonephritis. Current data indicate that at least four processes contribute to development of IgA nephropathy. Patients with IgA nephropathy often have a genetically determined increase in circulating
Hitoshi, Suzuki, Krzysztof, Kiryluk, Jan, Novak, Zina, Moldoveanu, Andrew B, Herr, Matthew B, Renfrow, Robert J, Wyatt, Francesco, Scolari, Jiri, Mestecky, Ali G, Gharavi, Bruce A, Julian   +10 more
openaire   +2 more sources

IgA nephropathy presenting with pulmonary thromboembolism and renal artery infarct [PDF]

, 2019
Background: Venous and arterial thromboembolism are frequently seen in nephrotic syndrome. They generally occur during periods of sustained proteinuria in patients who are not responding to treatment and more commonly seen in minimal change disease and ...
Anil Mathew, Rajesh Nair, Madhav Venkatesan, Zachariah Paul, Sandeep Sreedharan, George Kurian, Seethalekshmy NV   +6 more
core   +1 more source

IgA Nephropathy [PDF]

Journal of the American Society of Nephrology, 2000
IgA nephropathy (IgAN), a mesangial proliferative glomerulonephritis (GN), is the most common GN in all parts of the world where renal biopsy is widely practiced. It is unique among glomerular diseases in being defined by immunohistochemical findings, i.e., mesangial deposition of IgA, rather than by light microscopy.
Jürgen, Floege, John, Feehally
openaire   +2 more sources

Plasma phospholipid metabolic profiling and biomarkers of mouse IgA nephropathy

, 2006
IgA nephropathy is the most common form of glomerulonephritis (GN) and it Could progress to end-stage renal failure within 10 years. Participating in biological processes in various pathways, phospholipids as a class of important Constituents in the ...
许国旺, Wang, Chang, Kong, Hongwei, Cai, Zongwei, Jia, Lewen, Xu, Guowang   +5 more
core   +1 more source

Novel Treatment Paradigms: Primary IgA Nephropathy

Kidney International Reports
IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Approximately 30% to 45% of patients progress to kidney failure (KF) within 20 to 25 years of diagnosis, and there has long been a lack of effective treatments.
Haresh Selvaskandan, Jonathan Barratt, Chee Kay Cheung   +2 more
doaj   +1 more source

Steroid therapy is effective for IgA nephropathy after liver transplantation in a pediatric patient

Clinical Case Reports, 2021
Hepatic IgA nephropathy is a complication of chronic liver disease. IgA nephropathy after liver transplantation is rare, especially in children, and carries a significant risk factor for chronic renal failure and mortality.
Hiroshi Tamura, Shohei Kuraoka, Hitoshi Nakazato   +2 more
doaj   +1 more source

Secondary IgA nephropathy [PDF]

Kidney International, 2018
IgA nephropathy is the most common primary glomerulonephritis worldwide. Its frequent coexistence with inflammatory, infectious, or malignant processes raises the possibility of a pathologic rather than coincidental association. Major strides have been made to elucidate the underlying pathophysiologic events that culminate in the development of primary
Manish K, Saha, Bruce A, Julian, Jan, Novak, Dana V, Rizk   +3 more
openaire   +2 more sources

Immunoglobulin A-nephropathy: modern view of the problem and treatment options

Лечащий Врач, 2021
The presented review discusses the mechanisms of development, the issues of diagnosis and the possibility of therapy for IgAnephropathy. IgA-nephropathy is an immunocomplex lesion of the glomeruli, characterized by the predominant deposition of ...
I. T. Murkamilov, I. S. Sabirov, V. V. Fomin, Zh. A. Murkamilova   +3 more
doaj   +1 more source

The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy

Frontiers in Immunology, 2019
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is necessary for diagnosis, with routine immunofluorescence microscopy revealing dominant ...
Dana V. Rizk, Nicolas Maillard, Bruce A. Julian, Barbora Knoppova, Barbora Knoppova, Todd J. Green, Jan Novak, Robert J. Wyatt   +7 more
doaj   +1 more source

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source