Results 61 to 70 of about 149,546 (225)

Improving treatment decisions using personalized risk assessment from the International IgA Nephropathy Prediction Tool

, 2020
Immunosuppression in IgA nephropathy (IgAN) should be reserved for patients at high-risk of disease progression, which KDIGO guidelines determine based solely on proteinuria 1g or more/day.
John Feehally (753825), Reich, Heather N, Hong Zhang (25820), Jonathan Barratt (3387179), Feehally, John, Liu, Zhi-Hong, Cattran, Daniel C, Coppo, Rosanna, Daniel C Cattran (8956040), Canney, Mark, Dilshani Induruwage (8956031), Barbour, Sean J, Rosanna Coppo (4542127), Er, Lee, Ritsuko Katafuchi (5278760), Heather N Reich (8956037), Katafuchi, Ritsuko, Keiichi Matsuzaki (525710), International IgA Nephropathy Network (8956043), Matsuzaki, Keiichi, Barratt, Jonathan, Zhang, Hong, Mark Canney (843116), Induruwage, Dilshani, Yusuke Suzuki (525707), Zhi-Hong Liu (137039), Magistroni Riccardo, Suzuki, Yusuke, Sean J Barbour (8956028), Lee Er (8956034), For The International IgA Nephropathy   +30 more
core   +1 more source

Low incidence of IgA nephropathy in Blacks [PDF]

, 1985
Low incidence of IgA nephropathy in blacks. The clinical and pathologic features were evaluated in 106 IgA nephropathy patients identified in 1,753 consecutive patients undergoing renal biopsy in the southeastern United States. Special attention was paid
Jennette, J. Charles, Wilkman, Alice S., Wall, Sherri D., Wilkman, Alice, Wall, Sherri   +4 more
core   +1 more source

Correlation of Serum Immunoglobulin A and Immunoglobulin A / Complement 3 Ratio with IgA Nephropathy: One Year Prospective Study

Journal of Nobel Medical College
Background: IgA nephropathy is the most prevalent primary glomerulonephritis worldwide, characterized by the mesangial deposition of IgA immune complexes.Its clinical course is highly variable, ranging from indolent to rapidly progressive forms, and it ...
Nirajan Mainali, Keshika Kshatree
doaj   +1 more source

Breakthrough Hemolysis in Paroxysmal Nocturnal Hemoglobinuria: Mechanistic Insights and Management Strategies

Transfusion, EarlyView.
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder caused by somatic mutations in the PIGA gene, resulting in loss of glycosylphosphatidylinositol (GPI)‐anchored proteins, including the complement regulatory proteins, CD55 and CD59.
Ganesh Raman, Meghana Vivek, Rida Hasan, Siobán Keel, Laura Connelly‐Smith   +4 more
wiley   +1 more source

TREM2+ macrophages accumulate in childhood IgA nephropathy and soluble TREM2 represents a reliable non‐invasive biomarker

Experimental Physiology, EarlyView.
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu, Xuan Gang, Jingjing Wang, Guoping Huang, Qiuyu Li, Weizhong Gu, Haidong Fu, Jianhua Mao   +7 more
wiley   +1 more source

Advancements in understanding the role of intestinal dysbacteriosis mediated mucosal immunity in IgA nephropathy

BMC Nephrology
IgA nephropathy, presently recognized as the foremost primary glomerular disorder, emerges as a principal contributor to renal failure globally, with its pathogenesis yet to be fully elucidated. Extensive research has highlighted the critical role of gut
Yitao Fan, Yan Wang, Han Xiao, Hui Sun
doaj   +1 more source

Research advances on the pathogenesis of IgA nephropathy

Linchuang shenzangbing zazhi, 2022
IgA nephropathy is the most common primary glomerular disease in the world. Up to 20%-40% of patients develop end-stage renal disease within 20 years after a definite diagnosis of renal biopsy.
Lu Fang-cao, Yuan Hong-ling
doaj  

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

Urinary uromodulin excretion predicts progression of chronic kidney disease resulting from IgA nephropathy. [PDF]

PLoS ONE, 2013
BACKGROUND: Uromodulin, or Tamm-Horsfall protein, is the most abundant urinary protein in healthy individuals. Recent studies have suggested that uromodulin may play a role in chronic kidney diseases.
Jingjing Zhou, Yuqing Chen, Ying Liu, Sufang Shi, Suxia Wang, Xueying Li, Hong Zhang, Haiyan Wang   +7 more
doaj   +1 more source

POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, Volume 101, Issue 10, Page 2632-2651, October 2026.
ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley   +1 more source