Results 61 to 70 of about 161,533 (212)

Efficacy and safety of artesunate for patients with IgA nephropathy: a study protocol for a multicenter, double-blind, randomized, placebo-controlled trial

Trials, 2022
Background IgA nephropathy is the most common glomerular disease and is a common cause of progression to end-stage renal disease in patients with kidney diseases.
Qi Chen, Zi Wang, Jicheng Lv, Lijun Liu, Hang Li, Weiwei Sun, Yanhong Huo, Yingbo Guo, Cun Shen, Shichao Li, Zhenjie Chen, Jingwei Zhou   +11 more
doaj   +1 more source

Association of urinary NGAL and early diagnosis and prognosis of IgA nephropathy

Zhongguo linchuang yanjiu, 2023
Objective To investigate the value of urinary neutrophil gelatinase-associated lipocalin (NGAL) in the early diagnosis of IgA nephropathy and its relationship with the cumulative survival rate of kidney in patients with IgA nephropathy.
SHI Jia-jia*, ZHU Guo-zhen
doaj   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

IgA Polyspecific autoantibodies in IgA nephropathy

, 1990
SUMMARY The specificity of circulating and kidney-bound IgA during IgA nephropathy is suit a matter of discussion. In the present study, high levels of IgA antibodies directed against a panel of self and non-out of the seven kidney ...
H LOUZIR, P DRUET, E DRUET, S AVRAMEAS, P MATSIOTA, P DOSQUET   +5 more
core   +1 more source

Glycosyltransferase expression in IgA[superscript +] B cells in IgA nephropathy

, 2014
IgA nephropathy is a common kidney disease classically presenting in the second to third decade with episodic haematuria following mucosal infection. Up to a third of patients will develop progressive renal failure requiring renal replacement therapy ...
Joanna Kathryn Fiona Boyd (7703114)
core   +5 more sources

Exploring the causal effect of complement and IgA nephropathy—a Mendelian randomization study

Renal Failure
IgA nephropathy, one of the most common primary glomerulonephritis worldwide, is still under investigation for its precise etiology. The widely accepted theory is the ‘four-hit model’ and subsequent complement and inflammatory responses.
Han Xu, Mengxiao Zou, Yichun Cheng, Shuwang Ge   +3 more
doaj   +1 more source

Half a century of IgA nephropathy: achievements, frustrations and challenges

Український Журнал Нефрології та Діалізу, 2018
IgA nephropathy is the most common glomerulonephritis worldwide. This disease has a tremendous economic impact because renal replacement therapy is expensive and hard-to-reach.
I.I. Lapchynska
doaj   +1 more source

Identification of C3d Complement Fragments in Lesional Tissues in ANCA‐Associated Vasculitis

ACR Open Rheumatology, Volume 8, Issue 11, November 2026.
Objective Antineutrophil cytoplasmic antibody–associated vasculitis (AAV) is typically described as “pauci‐immune” due to the absence or weak detection of Igs and complement activation within AAV tissue lesions. However, complement fragments have been recently reported in significant amounts in damaged tissue in AAV, notably in traps formed by ...
Claire Galand, Fei Liu, Katherine A. Vernon, Ravi Vats, Christine Lian, V. Michael Holers, Michael Woodbury, H. Terence Cook, David Cuthbertson, Nader Khalidi, Curry Koening, Carol A. Langford, Carol A. McAlear, Paul A. Monach, Christian Pagnoux, Jason A. Campagna, Stefan Wawersik, Shelia Violette, Peter A. Merkel, for the Vasculitis Clinical Research Consortium   +19 more
wiley   +1 more source

IgA nephropathy

Kidney International, 1995
IgAN is the most common type of glomerulonephritis worldwide, and is found more in men and distinctly less in blacks. It presents with macroscopic hematuria in about 40 to 45% of patients, with microscopic hematuria and proteinuria in about 35 to 40%, and with nephrotic syndrome or acute renal failure in the remainder.
openaire   +2 more sources

Correlation of Serum Immunoglobulin A and Immunoglobulin A / Complement 3 Ratio with IgA Nephropathy: One Year Prospective Study

Journal of Nobel Medical College
Background: IgA nephropathy is the most prevalent primary glomerulonephritis worldwide, characterized by the mesangial deposition of IgA immune complexes.Its clinical course is highly variable, ranging from indolent to rapidly progressive forms, and it ...
Nirajan Mainali, Keshika Kshatree
doaj   +1 more source