Results 81 to 90 of about 31,703 (224)
Aging Cell, Volume 25, Issue 6, June 2026.This study illustrates that omega‐3 PUFAs with their receptor FFAR4 alleviate tubular senescence and fibrosis in aged and fibrotic kidneys. Furthermore, we indicate that tubular FFAR4 improves renal senescence via 15d‐PGJ2‐PPARγ‐Klotho signaling, and suppresses kidney fibrosis by senescent tubular cell‐driven fibroblast activation.
Letian Yang +9 more
wiley +1 more source
IgA Polyspecific autoantibodies in IgA nephropathy
, 1990 SUMMARY The specificity of circulating and kidney-bound IgA during IgA nephropathy is suit a matter of discussion. In the present study, high levels of IgA antibodies directed against a panel of self and non-out of the seven kidney ...
H LOUZIR +5 more
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Glucocorticoids Reduce Aberrant O-Glycosylation of IgA1 in IgA Nephropathy Patients
Kidney & Blood Pressure Research, 2018 Background/Aims: IgA nephropathy is associated with aberrant O-glycosylation of IgA1, which is recognized by autoantibodies leading to the formation of circulating immune complexes. Some of them, after deposition into kidney mesangium, trigger glomerular
Petr Kosztyu +11 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 11, Page 2874-2889, June 2026.Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva +5 more
wiley +1 more source
IGA Nephropathy : From Molecules to Men /
, 1999 The author of this volume has studied IgA nephropathy for nearly 25 years, almost as long as primary IgA nephropathy has been recognized as a new disease.
Tomino, Y.
core
Introduction Immunoglobulin A (IgA) nephropathy is a common immune-mediated kidney disease leading to high blood pressure and may progress to kidney failure. None of the present treatments are disease-modifying or prolong life.
Doggrell, Sheila A
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Low incidence of IgA nephropathy in Blacks
, 1985 Low incidence of IgA nephropathy in blacks. The clinical and pathologic features were evaluated in 106 IgA nephropathy patients identified in 1,753 consecutive patients undergoing renal biopsy in the southeastern United States. Special attention was paid
Jennette, J. Charles +4 more
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Clinical Transplantation, Volume 40, Issue 6, June 2026.ABSTRACT Background Pneumocystis jirovecii is an opportunistic fungus responsible for Pneumocystis pneumonia (PJP) in hosts with impaired cell‐mediated immunity, particularly solid organ transplant recipients. The aim of our study was to identify risk factors associated with PJP in kidney transplant recipients (KTRs).
Solenne Hulot +9 more
wiley +1 more source
Clinical, genetic and molecular aspects of membranous nephropathy
, 2011 Membranous Nephropathy (MN) is one of the leading causes of end-stage renal disease (ESRD). MN is an autoimmune disease in which autoantibodies target antigens at the level of the glomerular basement membrane.
Stanescu, H.C.
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, 2011 IgA nephropathy is the most common primary glomerulonephritis worldwide. The clinical spectrum covers a wide range of features from minor urinary abnormalities (asymptomatic hematuria and mild proteinuria with normal renal function) to acute and chronic ...
Tibor Kovács +6 more
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