Results 91 to 100 of about 149,546 (225)
Clinical Pharmacology in Drug Development, Volume 15, Issue 9, September 2026.Abstract Increased activity in the complement alternative pathway (AP) plays a key role in diseases such as IgA nephropathy (IgAN). This first‐in‐Japanese double‐blind Phase 1 study investigated the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of sefaxersen (RO7434656), an antisense oligonucleotide targeting complement factor ...
Takakazu Sato +3 more
wiley +1 more source
, 2011 IgA nephropathy is the most common primary glomerulonephritis worldwide. The clinical spectrum covers a wide range of features from minor urinary abnormalities (asymptomatic hematuria and mild proteinuria with normal renal function) to acute and chronic ...
Tibor Kovács +6 more
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Role of Tertiary Lymphoid Structures in Autoimmune Diseases and Cancer
MedComm, Volume 7, Issue 9, September 2026.Schematic overview of tertiary lymphoid structures (TLSs): The development process, detection, and the immune function that depends on the environment in different disease contexts of TLS. TLSs originate from loose lymphoid aggregates that acquire ordered follicular architecture to become primary follicular‐like TLS, before maturing into ...
Ze Yan +11 more
wiley +1 more source
Role of macromolecular IgA in IgA nephropathy [PDF]
, 2005 Role of macromolecular IgA in IgA nephropathy Primary IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis, leading to progressive renal failure in almost one third of the patients.
Van Der Boog, Paul J.M. +7 more
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Diagnosis and treatment of patients with IgA nephropathy in Japan
Kidney Research and Clinical Practice, 2016 Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of people from all racial and ethnic groups. Although CKD is not one specific disease, it is a comprehensive syndrome that includes IgA nephropathy.
Yasuhiko Tomino
doaj +1 more source
Molecular Genetics &Genomic Medicine, Volume 14, Issue 9, September 2026.This study describes the first reported case of concurrent sitosterolemia (STSL) and nephronophthisis (NPHP). Additionally, we provide a systematic review of the clinical and genetic characteristics of Chinese STSL patients, representing the largest comprehensive cohort in China to date.
Dan Ding +4 more
wiley +1 more source
, 1986 In the introduction of this thesis basic motives and assumptions are stated. In chapter I data from literature on IGA-Nephropathy upto December 1983 are reviewed. A heuristic system of work-hypotheses concerning mesangial IgAdeposition is developed. Some
Beukhof, Johan Richard +1 more
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Current therapeutic management of diabetic nephropathy [PDF]
, 1994 Roughly 40% of all patients with insulin-dependent diabetes mellitus (IDDM) develop diabetic nephropathy with proteinuria, hypertension and a decrease in glomerular filtration rate 10 to 20 years after the onset of the disease, and 5 years later most ...
Kohler, S. M., Krämer, Bernhard K.
core +1 more source
IgG Subclass (IgG1‐4) and IgA Autoantibody Profiles Against Muscle‐Specific Kinase in a Greek Cohort
Muscle &Nerve, Volume 74, Issue S1, Page S132-S141, September 2026.ABSTRACT Introduction/Aims Muscle‐specific kinase myasthenia gravis (MuSK‐MG) is an autoimmune neuromuscular disorder predominantly mediated by IgG4 autoantibodies disrupting MuSK signaling. The contribution of other isotypes remains incompletely defined. We characterized the serological profile of a Greek cohort of MuSK‐MG patients.
Sofia‐Natsοuko Gkotzamani +22 more
wiley +1 more source
Primary IgA nephropathy: current challenges and future prospects
, 2018 Rose S Penfold, Maria Prendecki, Stephen McAdoo, Frederick WK Tam Renal and Vascular Inflammation Section, Department of Medicine, Imperial College London, London, UK Abstract: IgA nephropathy (IgAN) is the most common form of primary ...
Prendecki M +3 more
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