Results 51 to 60 of about 31,703 (224)

Gene Expression Analysis in Tubule Interstitial Compartments Reveals Candidate Agents for IgA Nephropathy

Kidney & Blood Pressure Research, 2014
Background/Aims: Our aim was to explore the molecular mechanism underlying development of IgA nephropathy and discover candidate agents for IgA nephropathy.
Jinling Wang, Juan Cao
doaj   +1 more source

Possible Link between IgA Nephropathy and B-cell Acute Lymphoblastic Leukemia

Turkish Journal of Nephrology, 2020
IgA nephropathy (IgA-N) is the most common glomerulonephritis type globally. IgA-N is usually accepted as a kidney disease; however, IgA-N has been reported with infections, autoimmune diseases, and malignancies in the literature.
Eray Eroğlu, Uğur Türkmen, İsmail Koçyiğit, Hülya Akgün, Sümeyra Koyuncu, Murat Hayri Sipahioğlu, Bülent Tokgöz, Oktay Oymak   +7 more
doaj   +1 more source

Cesni‐cel (ARI0002h) in ultra‐high‐risk multiple myeloma with plasma cell leukaemia or central nervous system involvement

British Journal of Haematology, EarlyView.
ARI0002h induced response in 15/17 patients with plasma cell leukaemia (PCL)/central nervous system (CNS)‐multiple myeloma (MM) (87% achieved ≥ very good partial response [VGPR]) with a median progression‐free survival (PFS)/overall survival (OS) of 10.5 and 15.9 months respectively.
Carlos Jimenez‐Mira, Natalia Tovar, Núria Martínez‐Cibrián, Verónica González‐Calle, Nil Albiol, Nieves López‐Muñoz, Aina Oliver‐Caldés, Azucena González, José Miguel Mateos, Marta Español‐Rego, Laura Rosiñol, Manel Juan, Paola Charry, José María Sanchez‐Pina, Sergio Navarro, Daniel Munárriz, Lucía López‐Corral, Valentín Ortiz‐Maldonado, Sara Varea, Eulalia Olesti, Julio Delgado, Álvaro Urbano‐Ispizua, Joaquín Martínez‐López, María Victoria Mateos, Luis Gerardo Rodríguez‐Lobato, Carlos Fernández de Larrea   +25 more
wiley   +1 more source

IgA nephropathy enigma [PDF]

Clinical Immunology, 2016
IgA nephropathy (IgAN) is the leading cause of primary glomerulonephritis in the world. The disease is characterized by the presence of IgA-containing immune complexes in the circulation and in mesangial deposits with ensuing glomerular injury. Although in humans there are two IgA subclasses, only IgA1 molecules are involved.
Jiri, Mestecky, Jan, Novak, Zina, Moldoveanu, Milan, Raska   +3 more
openaire   +2 more sources

Australian clinical practice guideline: diagnosis and treatment of idiopathic multicentric Castleman disease

Internal Medicine Journal, EarlyView.
Abstract Idiopathic multicentric Castleman disease (iMCD) is a rare condition. The pathogenesis is incompletely understood; however, interleukin‐6 (IL‐6) is a major mediator. The clinical presentation is heterogeneous, from mild constitutional symptoms to severe multi‐organ failure.
Dipti Talaulikar, Jun Yen Ng, Adam Bryant, Annmarie Bosco, Hugh C. Caterson, Pratyush Giri, Pravin Hissaria, Simon J. Harrison, Stephen Lade, Connull Leslie, Jacinta Perram, H. Miles Prince, Dejan Radeski, Maureen Rischmueller, Craig Wallington‐Gates, Nicholas Weber, Alberta Hoi   +16 more
wiley   +1 more source

Improving treatment decisions using personalized risk assessment from the International IgA Nephropathy Prediction Tool

, 2020
Immunosuppression in IgA nephropathy (IgAN) should be reserved for patients at high-risk of disease progression, which KDIGO guidelines determine based solely on proteinuria 1g or more/day.
John Feehally (753825), Reich, Heather N, Hong Zhang (25820), Jonathan Barratt (3387179), Feehally, John, Liu, Zhi-Hong, Cattran, Daniel C, Coppo, Rosanna, Daniel C Cattran (8956040), Canney, Mark, Dilshani Induruwage (8956031), Barbour, Sean J, Rosanna Coppo (4542127), Er, Lee, Ritsuko Katafuchi (5278760), Heather N Reich (8956037), Katafuchi, Ritsuko, Keiichi Matsuzaki (525710), International IgA Nephropathy Network (8956043), Matsuzaki, Keiichi, Barratt, Jonathan, Zhang, Hong, Mark Canney (843116), Induruwage, Dilshani, Yusuke Suzuki (525707), Zhi-Hong Liu (137039), Magistroni Riccardo, Suzuki, Yusuke, Sean J Barbour (8956028), Lee Er (8956034), For The International IgA Nephropathy   +30 more
core   +1 more source

Causal role of immune cells in IgA nephropathy: a mendelian randomization study

Renal Failure
Background Previous observational studies have shown that immune cells play an important role in IgA nephropathy. However, the specific causal relationship between the two is inconsistent.Methods We used a two-sample mendelian randomization(MR) analysis ...
Jinlian Shu, Yating Ge, Yonggui Wu
doaj   +1 more source

Clinical implications of imlifidase interference in antibody screening and transfusion management

Transfusion, EarlyView.
Abstract Background Imlifidase has received conditional approval from the EMA for desensitizing deceased donor kidney transplant recipients. It works by cleaving IgG into F(ab′)2 and Fc fragments, thereby reducing the risk of antibody‐mediated rejection. However, its impact on diagnostic assays remains understudied. Case Report We present the case of a
Zgjim Osmani, Aiko P. J. de Vries, Arjan Albersen   +2 more
wiley   +1 more source

Severity of Glomerulosclerosis Predicts Prognosis of IgA Nephropathy with Proteinuria [PDF]

, 2002
We determined the natural history of IgA nephropathy (IgAN) among patients who presented with proteinuria, and factors associated with the development of clinical events, namely blood pressure(BP)竕ｧ130/85 mmHg, serum creatinine 竕ｧ1.4mg/dl.
Tadokoro, Masato, Suyama, Naofumi, Horita, Yoshio, Taura, Kouichi   +3 more
core  

TREM2+ macrophages accumulate in childhood IgA nephropathy and soluble TREM2 represents a reliable non‐invasive biomarker

Experimental Physiology, EarlyView.
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu, Xuan Gang, Jingjing Wang, Guoping Huang, Qiuyu Li, Weizhong Gu, Haidong Fu, Jianhua Mao   +7 more
wiley   +1 more source