Results 51 to 60 of about 161,533 (212)

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Correlation of immunostaining findings with demographic data and variables of Oxford classification in IgA nephropathy [PDF]

, 2013
Background: Oxford classification for IgA nephropathy (IgAN) did not include pattern of immunostaining in the analysis. Objective: The aim of this study is to determine the potential correlation between the immunostaining data and morphologic variables ...
Ali momeni, Madihi, Yahya., Emami Naieni, Afsoon., Alireza Merikhi, Alaleh Ghiessari, Afsoon Emami Naieni, Merikhi, Alireza., Hamid Nasri, Yahya Madihi, Mardani, Saeed., Nasri, Hamid., Sajjadieh, Shahram., Gheissari, Alaleh., Saeed Mardani, Shahram Sajjadieh, Momeni, Ali.   +15 more
core   +3 more sources

Pathogenesis of IgA nephropathy

Kidney International, 1992
A 52-year-old man was referred to Leiden University Hospital for management of acute renal insufficiency. Several previous yearly medical examinations had demonstrated normal urinary sediment and renal function. His medical history included an appendectomy 40 years previously and the removal of a cyst in his neck 13 years previously.
Vanes, LA., Pirson, Yves, Harrington, JT., Muldowney, FP., Kassirer, JP., Davison, AM., Olmer, M., Rambausek, MH., Borsatti, A., Donohoe, JF., Rees, A., Remuzzi, G., Madias, NE.   +12 more
openaire   +2 more sources

Causal role of immune cells in IgA nephropathy: a mendelian randomization study

Renal Failure
Background Previous observational studies have shown that immune cells play an important role in IgA nephropathy. However, the specific causal relationship between the two is inconsistent.Methods We used a two-sample mendelian randomization(MR) analysis ...
Jinlian Shu, Yating Ge, Yonggui Wu
doaj   +1 more source

Real‐world observational study evaluating metabolic and kidney outcomes in patients living with chronic kidney disease and type 2 diabetes mellitus with obesity prescribed tirzepatide

Diabetic Medicine, EarlyView.
Abstract Background Obesity and type 2 diabetes mellitus (T2DM) accelerate chronic kidney disease (CKD) progression. Tirzepatide, a dual glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonist, has demonstrated metabolic and potential renoprotective benefits in clinical trials.
Jack E. Carruthers, Xi Yan Ooi, Dawn Goodall, Jo Reed, Rachna Bedi, Adrian McGrath, Michelle Willicombe, Parizad Avari, Andrew H. Frankel   +8 more
wiley   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source

Plasma phospholipid metabolic profiling and biomarkers of mouse IgA nephropathy

, 2006
IgA nephropathy is the most common form of glomerulonephritis (GN) and it Could progress to end-stage renal failure within 10 years. Participating in biological processes in various pathways, phospholipids as a class of important Constituents in the ...
许国旺, Wang, Chang, Kong, Hongwei, Cai, Zongwei, Jia, Lewen, Xu, Guowang   +5 more
core   +1 more source

Breakthrough Hemolysis in Paroxysmal Nocturnal Hemoglobinuria: Mechanistic Insights and Management Strategies

Transfusion, EarlyView.
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder caused by somatic mutations in the PIGA gene, resulting in loss of glycosylphosphatidylinositol (GPI)‐anchored proteins, including the complement regulatory proteins, CD55 and CD59.
Ganesh Raman, Meghana Vivek, Rida Hasan, Siobán Keel, Laura Connelly‐Smith   +4 more
wiley   +1 more source

Coexisting genetic kidney disease explains many cases of ‘familial’ IgA nephropathy where the proband has biopsy-confirmed mesangial IgA deposits

Frontiers in Medicine
BackgroundOne in seven people with IgA nephropathy has another apparently-affected family member. This study examined how often biopsy-proven familial and sporadic IgA nephropathy were associated with genetic kidney disease.MethodsEleven unrelated people
YuXin Li, Jing Zhang, Zhuo Jun Yin, Ziming Zhou, Bocheng Huang, Khalid Mahmood, Deb Colville, David Barit, Russell Auwardt, Robert Fassett, Kathy Paizis, Francesco Ierino, Timothy Pianta, David Langsford, Mary Huang, Judy Savige   +15 more
doaj   +1 more source

TREM2+ macrophages accumulate in childhood IgA nephropathy and soluble TREM2 represents a reliable non‐invasive biomarker

Experimental Physiology, EarlyView.
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu, Xuan Gang, Jingjing Wang, Guoping Huang, Qiuyu Li, Weizhong Gu, Haidong Fu, Jianhua Mao   +7 more
wiley   +1 more source