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Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
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Epidemiology of chronic renal diseases

International Urology and Nephrology, 1983
Autopsies of all uraemic patients in Leningrad for three years, and materials of the City Nephrological Service have demonstrated that the structures of nephrological diseases in their early and terminal stages were different. Chronic glomerulonephritis has been noted in patients with normal renal function just as often as chronic pyelonephritis but ...
S I, Ryabov, V V, Stavskaya
openaire   +2 more sources

Progression of chronic renal disease

American Journal of Kidney Diseases, 2003
Risk factors for progression of kidney disease include hypertension, proteinuria, male sex, obesity, diabetes mellitus, hyperlipidemia, smoking, high-protein diets, phosphate retention, and metabolic acidosis. Angiotensin II production upregulates the expression of transforming growth factor-beta1, tumor necrosis factor-alpha, nuclear factor-kappaB ...
Saulo, Klahr, Jeremiah, Morrissey
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Earnings and Chronic Renal Disease

Transplantation Proceedings, 2007
The number of patients with chronic renal disease (CRD) has grown worldwide, especially in Brazil. This disease increases the public expenditure, besides having other economic implications and impacts. Most patients are in the productive age, range (15-49 years old).The purpose of this study was to estimate the income losses due to CRD using data from ...
M R, Godoy, G, Balbinotto Neto, E P, Ribeiro   +2 more
openaire   +2 more sources

Chronic Renal Disease in Pregnancy

Obstetrics & Gynecology, 2006
The purpose of this review was to examine the impact of varying degrees of renal insufficiency on pregnancy outcome in women with chronic renal disease. Our search of the literature did not reveal any randomized clinical trials or meta-analyses. The available information is derived from opinion, reviews, retrospective series, and limited observational ...
Susan M, Ramin, Alex C, Vidaeff, Edward R, Yeomans, Larry C, Gilstrap   +3 more
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Analgesics and chronic renal disease

Current Opinion in Nephrology and Hypertension, 1996
Intake of analgesics has been associated with the presence of chronic renal diseases in a number of studies. Phenacetin was the first drug to be linked with chronic renal disease. Four out of five case-control studies that have examined this issue have also demonstrated an association of acetaminophen use with renal disease.
M J, Klag, P K, Whelton, T V, Perneger
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Chronic renal disease

The Lancet, 2001
Sir—We disagree with Ruggenenti and colleagues’ (May 19, p 1601) interpretation of nutritional control of renal insufficiency. A systematic review has provided evidence-based data supporting the effectiveness of reduced protein intake in delaying end-stage renal disease. Ruggenenti and colleagues do not discuss those data.
Piero Ruggenenti, Arrigo Schieppati, Giuseppe Remuzzi   +2 more
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Silicosis and chronic renal disease

American Journal of Industrial Medicine, 2015
BackgroundSilica has been associated with end stage kidney disease and kidney dysfunction.MethodsCalculated glomerular filtration rate, history of kidney disease or chronic dialysis, elevated serum creatinine, and stages of chronic kidney disease among silicotics identified in Michigan's Silicosis Surveillance System from 1987 to 2009 were reviewed to ...
Melissa L, Millerick-May, Sarah, Schrauben, Mary Jo, Reilly, Kenneth D, Rosenman   +3 more
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Hyperuricemia and chronic renal disease

Journal of Chronic Diseases, 1971
Abstract Simultaneous serum creatinine and enzymatic spectrophotometric uric acid determinations were performed in a group of 25 patients with known renal disease. The presence or absence of six other factors associated with hyperuricemia was also documented. A group of 41 middle-aged white male volunteers, who had been found to have hyperuricemia by
G E, Gresham, M D, Keller
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Tuberculosis and Chronic Renal Disease

Seminars in Dialysis, 2003
AbstractThere is an increased risk (6.9‐ to 52.5‐fold) of tuberculosis (TB) in patients with chronic renal failure and on dialysis as compared to the general population. The symptomatology in renal patients is often insidious and nonspecific, mimicking uremic symptoms, whereas the localization is often extrapulmonary (most frequently tuberculous ...
Magdi M, Hussein, Jaap M, Mooij, Haysam, Roujouleh   +2 more
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