Results 51 to 60 of about 591,080 (338)

Projecting the Burden of Chronic Kidney Disease in a Developed Country and Its Implications on Public Health

International Journal of Nephrology, 2018
Background. Chronic Kidney Disease (CKD) is a major public health problem worldwide. There is limited literature on a model to project the number of people with CKD. This study projects the number of residents with CKD in Singapore by 2035 using a Markov
L. Y. Wong, A. S. T. Liew, W. T. Weng, C. K. Lim, A. Vathsala, M. P. H. S. Toh   +5 more
doaj   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Anemia among Chinese patients with chronic kidney disease and its association with quality of life - results from the Chinese cohort study of chronic kidney disease (C-STRIDE)

BMC Nephrology, 2021
Background Anemia is one of the common complications in patients with chronic kidney disease (CKD). However, there is no systematic investigation on the prevalence of anemia in CKD patients and its relationship with the quality of life in China.
Yan Shen, Jinwei Wang, Jing Yuan, Li Yang, Fangfang Yu, Xiaolei Wang, Ming-Hui Zhao, Luxia Zhang, Yan Zha, the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)   +9 more
doaj   +1 more source

Clinical and Pathological Characteristics of Patients With Nonproteinuric Diabetic Nephropathy

Frontiers in Endocrinology, 2021
IntroductionAs the most common complication of diabetes mellitus (DM), diabetic nephropathy (DN) was initially considered to begin with proteinuria preceding the progression of renal insufficiency.
Dong-Yuan Chang, Dong-Yuan Chang, Dong-Yuan Chang, Dong-Yuan Chang, Dong-Yuan Chang, Meng-Rui Li, Meng-Rui Li, Meng-Rui Li, Meng-Rui Li, Meng-Rui Li, Xiao-Juan Yu, Xiao-Juan Yu, Xiao-Juan Yu, Xiao-Juan Yu, Xiao-Juan Yu, Su-Xia Wang, Su-Xia Wang, Su-Xia Wang, Su-Xia Wang, Su-Xia Wang, Min Chen, Min Chen, Min Chen, Min Chen, Min Chen, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao   +29 more
doaj   +1 more source

Sympatho-renal axis in chronic disease [PDF]

Clinical Research in Cardiology, 2011
Essential hypertension, insulin resistance, heart failure, congestion, diuretic resistance, and functional renal disease are all characterized by excessive central sympathetic drive. The contribution of the kidney's somatic afferent nerves, as an underlying cause of elevated central sympathetic drive, and the consequences of excessive efferent ...
Felix Mahfoud, Markus P. Schlaich, Michael Böhm, Paul A. Sobotka, Henry Krum, Uta C. Hoppe   +5 more
openaire   +3 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Clinical Phenotyping of Long COVID Patients Evaluated in a Specialized Neuro‐COVID Clinic

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To report Long COVID characteristics and longitudinal courses of patients evaluated between 4/14/21–4/14/22 at the University of Pennsylvania Neurological COVID Clinic (PNCC), including clinical symptoms, neurological examination findings, and neurocognitive screening tests from a standardized PNCC neurological evaluation approach ...
Luana D. Yamashita, Neel Desai, Abigail R. Manning, Caitlin Pileggi, Sara Manning Peskin, Danielle K. Sandsmark, Dennis L. Kolson, Matthew K. Schindler   +7 more
wiley   +1 more source

Compound Heterozygous MRPS14 Variants Associated With Leigh Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT MRPS14 (uS14m) is a nuclear‐encoded ribosomal protein important for mitochondria‐specific translation. To date, only a single individual with a recessive MRPS14‐related disorder (also known as COXPD38) has been reported. We report an additional subject possessing novel compound heterozygous MRPS14 variants (p.Asp37Asn, p.Asn60Asp). The subject
Maria Gabriela Otero, Christina Freeman, Ruchi Shah, Renkui Bai, Hong Cui, Marian Castro, Zachary Myers, Eric Choy, Derek Chan, Molly Easter, Sophia Y. Zhao, Madeline Babros, Ruchi Garg, Matthew Deardorff, Franklin Moser, Tyler Mark Pierson   +15 more
wiley   +1 more source

Renal Parenchymal Area and Kidney Collagen Content [PDF]

arXiv, 2016
The extent of renal scarring in chronic kidney disease (CKD) can only be ascertained by highly invasive, painful and sometimes risky tissue biopsy. Interestingly, CKD-related abnormalities in kidney size can often be visualized using ultrasound. Nevertheless, not only does the ellipsoid formula used today underestimate true renal size but also the ...
arxiv  

Arterial stiffening provides sufficient explanation for primary hypertension [PDF]

, 2013
Hypertension is one of the most common age-related chronic diseases and by predisposing individuals for heart failure, stroke and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense research efforts over many decades.
arxiv   +1 more source