Results 61 to 70 of about 7,324,613 (292)

Complement 5a receptor 2 attenuates diabetic kidney disease by promoting mitochondria-associated endoplasmic reticulum membrane formation mediated by PSS-MFN2 interaction

Cell Discovery
Complement-mediated metabolic disorders are considered important contributors to the pathogenesis of diabetic kidney disease (DKD). This study investigated the non-canonical roles of complement 5a receptor 2 (C5aR2) in metabolism and its underlying ...
Yi-yang Zhao, Yi-hui Wang, Zi-han Li, Dong-yuan Chang, Lin Nie, Ming-hui Zhao, Sydney Chi Wai Tang, Min Chen   +7 more
doaj   +1 more source

Development of a measure of caregiver burden in paediatric chronic kidney disease: the Paediatric Renal Caregiver Burden Scale [PDF]

, 2014
To inform the development of a measure of caregiver burden for carers of children with chronic kidney disease, interviews were conducted with 16 caregivers and 10 renal healthcare professionals. A pool of 97 items generated from interviews was reduced to
Holttum, S., Horthi, D., Marks, S., Parham, R., Jacyna, N., Camic, P.   +5 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Screening of key genes in the pathogenesis of muscle atrophy in CKD-PEW children based on RNA sequencing

BMC Medical Genomics, 2023
Background In children with CKD, Protein Energy Wasting (PEW) is common, which affects the outcome of children and is an important cause of poor prognosis. We are aiming to explore the pathogenesis of muscle wasting in CKD-PEW children.
Liang Ying, Jiang Yeping, Wang Hui, Zhou Nan, FuQian, Shen Ying   +5 more
doaj   +1 more source

CHRONIC RENAL FAILURE AND PERIODONTAL DISEASE

Renal Failure, 2000
In order to define the effects of chronic renal failure (CRF) in the progress of gingival inflammation, we studied 6 patients (4 male, 2 female) with CRF who were on chronic hemodialysis for 4.25 (range 1-15) years. Six healthy individuals, age and sex matched were used as controls.
Kitsou, V. K., Konstantinidis, A., Siamopoulos, K. C.   +2 more
openaire   +3 more sources

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Clinical application of deep learning-based measurement of glomerular morphometry in IgAN

Frontiers in Immunology
BackgroundAccurate glomerular pathology assessment is crucial for predicting outcomes and guiding treatment in IgA nephropathy (IgAN). Although the Oxford classification provides a standardized histological assessment, it is semi-quantitative and ...
Lin-lin Xu, Xing-kuo Zhang, Zhen-zheng Dong, Pei Chen, Lei Jiang, Li-jun Liu, Xu-jie Zhou, Ji-cheng Lv, Li Xiao, Su-fang Shi, Hong Zhang   +10 more
doaj   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

The cost of implementing UK guidelines for the management of chronic kidney disease [PDF]

, 2007
Background. Chronic kidney disease (CKD) is a major public health problem. In the UK, guidelines have been developed to facilitate case identification and management.
B. Klebe, Stevens, PE, H. Hobbs, Lamb, EJ, Cooley, R, Irving, J, Hobbs, H, D. J. O'Donoghue, Farmer, CKT, J. New, Middleton, R, S. de Lusignan, Klebe, B, J. Irving, O'Donoghue, DJ, John, I, R. Middleton, I. John, P. E. Stevens, R. Cooley, de Lusignan, S, New, J, C. K.T. Farmer, E. J. Lamb, Hobbs, Helen, John, Ian, Klebe, Bernhard, Middleton, Rachel, Stevens, Paul E., New, John, Cooley, Roger, Lamb, Edmund J., O'Donoghue, Donal J., Farmer, Chris, Irving, Jean, de Lusignan, Simon   +35 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source