Results 1 to 10 of about 12,711 (259)

PLA2R1 and HLA-DQA1 SNP in patients with primary membranous nephropathy. [PDF]

PLoS ONE
BackgroundPrimary membranous nephropathy is a widely recognized autoimmune disease associated with podocyte antigens; the most important autoantigen is PLA2R1. PLA2R1 and HLA-DQA1 play important roles in the production of pathogenic antibodies.
Junyi Zhou, Zhijian Zhang, Kezhi Zhou, Leting Zhou, Jing Xue, Bin Liu, Xiran Zhang, Ting Cai, Biao Huang, Yi Zhang, Zhigang Hu, Liang Wang, Xiaobin Liu   +12 more
doaj   +3 more sources

Mechanisms of Primary Membranous Nephropathy [PDF]

Biomolecules, 2021
Membranous nephropathy (MN) is an autoimmune disease of the kidney glomerulus and one of the leading causes of nephrotic syndrome. The disease exhibits heterogenous outcomes with approximately 30% of cases progressing to end-stage renal disease.
Yan Gu, Hui Xu, Damu Tang
doaj   +5 more sources

Primary Membranous Nephropathy With Enhanced Staining of Exostosin 1/Exostosin 2 in the Glomeruli: A Report of 2 Cases

Kidney Medicine, 2021
Technological advances have allowed the discovery of 6 subtypes of membranous nephropathy based on target antigens: M-type phospholipase A2 receptor (PLA2R), thrombospondin type 1 domain-containing 7A (THSD7A), neural epidermal growth factor-like 1 ...
Takamasa Iwakura, Chiemi Ema, Taichi Sato, Shinsuke Isobe, Tomoyuki Fujikura, Naro Ohashi, Akihiko Kato, Hideo Yasuda   +7 more
doaj   +3 more sources

Establishing a differential diagnosis model between primary membranous nephropathy and non-primary membranous nephropathy by machine learning algorithms [PDF]

Renal Failure
Context Four algorithms with relatively balanced complexity and accuracy in deep learning classification algorithm were selected for differential diagnosis of primary membranous nephropathy (PMN).Objective This study explored the most suitable ...
Shangmei Cao, Shaozhe Yang, Bolin Chen, Xixia Chen, Xiuhong Fu, Shuifu Tang   +5 more
doaj   +4 more sources

Primary Membranous Glomerulonephritis in a Young Patient with Proteinuria [PDF]

Turkish Journal of Internal Medicine, 2021
Membranous nephropathy is a common form of glomerulonephritis that typically presents with nephrotic syndrome between the 3rd and 5th decades and one-third of patients experience spontaneous remission.
Ece Ünal Çetin, Adil Uğur Çetin
doaj   +3 more sources

Efficacy and safety of obinutuzumab as rescue therapy for rituximab-resistant and rituximab-recurrent primary membranous nephropathy: a retrospective cohort study [PDF]

Open Medicine
With the recognition of membranous nephropathy as an autoimmune disease, targeting B-cells has emerged as an effective therapeutic agent for primary membranous nephropathy (PMN).
Tian Li, Pei Huaying, Dong Tianhua, Zhou Mengsi, Li Shaomei, Zhao Xi, Liang Xuzhi, Xing Lingling   +7 more
doaj   +2 more sources

Comparative efficacy and safety of rituximab versus cyclophosphamide with steroids in primary membranous nephropathy: a systematic review and meta-analysis [PDF]

BMC Nephrology
Background Primary membranous nephropathy (PMN) is a leading cause of nephrotic syndrome in adults. In some patients, PMN can be severe or continue to worsen even after 6 months of supportive treatment.
Fangjiao Huang, Chenxin Fu, Maorong Liu, Peiyu Wu, Yanfang Li, Zhuguang Lu, Yanlei Li, Yifeng Xie   +7 more
doaj   +2 more sources

Nomogram for thromboembolic events in primary membranous nephropathy associated with PLA2R antibody [PDF]

Scientific Reports
Patients with nephrotic syndrome, particularly those with primary membranous nephropathy (pMN), are at a heightened risk of thromboembolic events.
Zihan Zhai, Yanhong Guo, Lu Yu, Yulin Wang, Liuwei Wang, Qiuhong Li, Yapei Yuan, Lin Tang   +7 more
doaj   +2 more sources

Post-Transplant Thrombotic Microangiopathy due to a Pathogenic Mutation in Complement Factor I in a Patient With Membranous Nephropathy: Case Report and Review of Literature

Frontiers in Immunology, 2022
Thrombotic microangiopathy (TMA) is characterized by microangiopathic hemolytic anemia, thrombocytopenia and organ injury occurring due to endothelial cell damage and microthrombi formation in small vessels.
Maryam Saleem, Sana Shaikh, Zheng Hu, Nicola Pozzi, Anuja Java   +4 more
doaj   +1 more source

Treatment of membranous nephropathy: Perspectives on current and future therapies

Frontiers in Nephrology, 2023
Primary membranous nephropathy remains one of the most frequent causes of nephrotic syndrome in adults. It is an autoimmune disorder in which auto-antibodies target antigens at the podocytes cell membrane–basement membrane interface. Our understanding of
Monarch Shah, Andrew DeLaat, Corey Cavanaugh   +2 more
doaj   +1 more source