Results 1 to 10 of about 12,518 (225)

Contemporary review of primary membranous nephropathy [PDF]

Frontiers in Immunology
Primary membranous nephropathy (PMN) is a single-organ autoimmune disease caused by autoantibodies targeting podocyte-associated antigens, most commonly phospholipase A2-receptor (PLA2R).
Edward J. Filippone, John L. Farber
doaj   +3 more sources

Primary Membranous Nephropathy With Enhanced Staining of Exostosin 1/Exostosin 2 in the Glomeruli: A Report of 2 Cases

Kidney Medicine, 2021
Technological advances have allowed the discovery of 6 subtypes of membranous nephropathy based on target antigens: M-type phospholipase A2 receptor (PLA2R), thrombospondin type 1 domain-containing 7A (THSD7A), neural epidermal growth factor-like 1 ...
Takamasa Iwakura, Chiemi Ema, Taichi Sato, Shinsuke Isobe, Tomoyuki Fujikura, Naro Ohashi, Akihiko Kato, Hideo Yasuda   +7 more
doaj   +3 more sources

PLA2R1 and HLA-DQA1 SNP in patients with primary membranous nephropathy. [PDF]

PLoS ONE
BackgroundPrimary membranous nephropathy is a widely recognized autoimmune disease associated with podocyte antigens; the most important autoantigen is PLA2R1. PLA2R1 and HLA-DQA1 play important roles in the production of pathogenic antibodies.
Junyi Zhou, Zhijian Zhang, Kezhi Zhou, Leting Zhou, Jing Xue, Bin Liu, Xiran Zhang, Ting Cai, Biao Huang, Yi Zhang, Zhigang Hu, Liang Wang, Xiaobin Liu   +12 more
doaj   +2 more sources

Obinutuzumab is effective for refractory primary membranous nephropathy [PDF]

BMC Nephrology
Purpose Primary membranous nephropathy has been recognized as an autoimmune disease since the discovery of anti-phospholipase A2 receptor (PLA2R) antibody.
Na Zhao, Ping Chen, Juan Chen, Baobao Wang, Xueqing Tang, Lijun Tang, Zunsong Wang, Ying Zhang   +7 more
doaj   +2 more sources

Efficacy and safety of obinutuzumab as rescue therapy for rituximab-resistant and rituximab-recurrent primary membranous nephropathy: a retrospective cohort study [PDF]

Open Medicine
With the recognition of membranous nephropathy as an autoimmune disease, targeting B-cells has emerged as an effective therapeutic agent for primary membranous nephropathy (PMN).
Tian Li, Pei Huaying, Dong Tianhua, Zhou Mengsi, Li Shaomei, Zhao Xi, Liang Xuzhi, Xing Lingling   +7 more
doaj   +2 more sources

Comparative efficacy and safety of rituximab versus cyclophosphamide with steroids in primary membranous nephropathy: a systematic review and meta-analysis [PDF]

BMC Nephrology
Background Primary membranous nephropathy (PMN) is a leading cause of nephrotic syndrome in adults. In some patients, PMN can be severe or continue to worsen even after 6 months of supportive treatment.
Fangjiao Huang, Chenxin Fu, Maorong Liu, Peiyu Wu, Yanfang Li, Zhuguang Lu, Yanlei Li, Yifeng Xie   +7 more
doaj   +2 more sources

Post-Transplant Thrombotic Microangiopathy due to a Pathogenic Mutation in Complement Factor I in a Patient With Membranous Nephropathy: Case Report and Review of Literature

Frontiers in Immunology, 2022
Thrombotic microangiopathy (TMA) is characterized by microangiopathic hemolytic anemia, thrombocytopenia and organ injury occurring due to endothelial cell damage and microthrombi formation in small vessels.
Maryam Saleem, Sana Shaikh, Zheng Hu, Nicola Pozzi, Anuja Java   +4 more
doaj   +1 more source

Treatment of membranous nephropathy: Perspectives on current and future therapies

Frontiers in Nephrology, 2023
Primary membranous nephropathy remains one of the most frequent causes of nephrotic syndrome in adults. It is an autoimmune disorder in which auto-antibodies target antigens at the podocytes cell membrane–basement membrane interface. Our understanding of
Monarch Shah, Andrew DeLaat, Corey Cavanaugh   +2 more
doaj   +1 more source

Primary Membranous Glomerulonephritis in a Young Patient with Proteinuria

Turkish Journal of Internal Medicine, 2021
Membranous nephropathy is a common form of glomerulonephritis that typically presents with nephrotic syndrome between the 3rd and 5th decades and one-third of patients experience spontaneous remission.
Ece Ünal Çetin, Adil Uğur Çetin
doaj   +1 more source

The value of repeat kidney biopsy during an atypical course of membranous nephropathy

BMC Nephrology, 2022
Background The clinical trajectory for patients with primary membranous nephropathy ranges widely from spontaneous remission to a rapid decline in kidney function.
Sumaiya Ahmed, David Massicotte-Azarniouch, Mark Canney, Clare Booth, Paula Blanco, Gregory L. Hundemer   +5 more
doaj   +1 more source