Pathophysiology of ANCA-associated vasculitides: Are ANCA really pathogenic? [PDF]
Kidney International, 2004 The strong relation between antineutrophil cytoplasmic autoantibodies (ANCA) and primary vasculitic syndromes suggests a pathophysiological role for ANCA. Experimental evidence for the pathogenic potential of ANCA has been derived from in vitro studies that demonstrate that ANCA can activate tumour necrosis factor alpha primed neutrophils, monocytes ...
Peter Heeringa, J W Cohen Tervaert
exaly +5 more sources
ANCA associated vasculitis [PDF]
BMJ, 2020 ### What you need to know Nicola, 44, goes to her general practitioner with a one month history of fatigue and night sweats. Physical examination is unremarkable. The duration of her symptoms prompts her GP to consider systemic inflammatory disease. Urinalysis is positive for blood and protein, and blood tests show new renal impairment (serum creatine
Hunter, Robert W +4 more
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The effect of various forms of treatment of vasculitis on C3, C4 and C5a complement levels in infants and children attending Assiut University Children Hospital (AUCH) [PDF]
E3S Web of Conferences, 2023 Vasculitis is an umbrella term for various and heterogeneous disorders sharing the presence of inflammation of blood vessel walls (Geetha & Jefferson, 2020).
Fatthi Dalal Abdullah
doaj +1 more source
Interstitial Lung Disease and Diffuse Alveolar Hemorrhage, the Two Key Pulmonary Manifestations in Microscopic Polyangiitis [PDF]
Tuberculosis and Respiratory Diseases, 2021 Microscopic polyangiitis (MPA) is an antineutrophil cytoplasmic antibody (ANCA)‒associated necrotizing vasculitis, which mainly affects small vessels in various organs, especially the lungs. The two key pulmonary manifestations, interstitial lung disease
Min Jung Kim, Kichul Shin
doaj +1 more source
Journal of Experimental Orthopaedics, 2021 Purpose The aim is to compare the results of isolated hip arthroscopy in patients with borderline dysplasia with Lateral center edge angle (LCEA) between 18° and 25° with a control group of patients with normal LCEA (> 25°).
Enrico Tassinari +8 more
doaj +1 more source
Cementless Total Hip Arthroplasty After an Iatrogenic Subtrochanteric Fracture due to Hardware Removal: A Case Report [PDF]
Hospital Practices and Research, 2019 Introduction: Total hip arthroplasty (THA) after proximal femoral fixation is a challenging procedure due to possible hardware-related complications. Case presentation: A 78-year-old female with hip osteoarthritis had a proximal femoral osteotomy fixed ...
Francesco Castagnini +3 more
doaj +1 more source
AB0593 Anca-associated vasculitis with both MPO-ANCA and PR3-ANCA shares characteristics of ANCA-associated vasculitis with single ANCA [PDF]
Annals of the Rheumatic Diseases, 2017 Background The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides are heterogeneous group of necrotizing inflammation of small vessel and the presence of the ANCA. ANCAs are defined according to the target antigens, leukocyte proteinase 3 (PR3) and myeloperoxidase (MPO).
SM Kim +4 more
openaire +1 more source
Microscopic polyangiitis: Modern concepts and treatment options
Научно-практическая ревматология, 2021 The article summarizes the modern concepts of microscopic polyangiitis (MPA), a primary ANCA-associated systemic necrotizing vasculitis without immune globulin deposition (pauci-immune) that affects mainly small vessels, while granulomatous inflammation ...
I. T. Murkamilov +6 more
doaj +1 more source
Standardisation of PR3-ANCA and MPO-ANCA: evaluation of certified reference materials [PDF]
Annals of the Rheumatic Diseases, 2020 Antineutrophil cytoplasmic antibodies (ANCAs) are important laboratory markers to support the diagnosis of ANCA-associated vasculitis. A 2017 international consensus states that high-quality immunoassays for proteinase-3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA can be used as the primary screening method for patients suspected of having granulomatosis
Xavier Bossuyt +8 more
openaire +3 more sources
Serum antibodies in first-degree relatives of patients with IBD: A marker of disease susceptibility? A follow-up pilot-study after 7 years [PDF]
, 2005 Introduction: Various disease-specific serum antibodies were described in patients with inflammatory bowel disease and their yet healthy first-degree relatives.
Bansi DS +29 more
core +5 more sources