Myeloperoxidase: a new target for the treatment of stroke?
Neural Regeneration Research, 2022 Myeloperoxidase is an important inflammatory factor in the myeloid system, primarily expressed in neutrophils and microglia. Myeloperoxidase and its active products participate in the occurrence and development of hemorrhagic and ischemic stroke ...
Ya-Wen Pan
exaly +3 more sources
Inhibition of Myeloperoxidase Activity in Cystic Fibrosis Sputum by Peptide Inhibitor of Complement C1 (PIC1). [PDF]
PLoS ONE, 2017 Myeloperoxidase is the major peroxidase enzyme in neutrophil granules and implicated in contributing to inflammatory lung damage in cystic fibrosis. Free myeloperoxidase is present in cystic fibrosis lung fluid and generates hypochlorous acid.
Pamela S Hair +3 more
doaj +3 more sources
A LINK BETWEEN ACTIVE MYELOPEROXIDASE AND CHLORINATED CERULOPLASMIN IN BLOOD PLASMA OF PATIENTS WITH CARDIOVASCULAR DISEASES [PDF]
Медицинская иммунология, 2018 Myeloperoxidase is a key factor promoting development of halogenative/oxidative stress under inflammatory conditions. Previously, we have discovered complexes including myeloperoxidase and its physiological inhibitor, ceruloplasmin in blood plasma of ...
A. V. Sokolov +6 more
doaj +3 more sources
Frontiers in Medicine, 2023 Despite significant progress in dialysis modalities, intermittent renal replacement therapy remains an “unphysiological” treatment that imperfectly corrects uremic disorders and may lead to low-grade chronic inflammation, neutrophil activation, and ...
Jean-Paul Cristol +6 more
doaj +1 more source
Myeloperoxidase-Sensitive T1 and T2 Switchable MR Imaging for Diagnosis of Nonalcoholic Steatohepatitis [PDF]
, 2023 Nonalcoholic steatohepatitis (NASH) is the critical stage in the development of nonalcoholic fatty liver disease (NAFLD) from simple and reversible steatosis to irreversible cirrhosis and even hepatocellular carcinoma (HCC).
Hui Jun Ting (14602980) +8 more
core +1 more source
Biodegradability of Carbon Nano-Onions by Human Myeloperoxidase and the Photo-Fenton Reaction [PDF]
, 2023 The biodegradability of graphene family materials (GFMs) in the environment and organisms is little understood to estimate their fate and possible byproducts. Herein, for the first time, we explored the biodegradability of multilayer fullerenes or carbon
Dr. Rajendra, Kurapati +7 more
core +1 more source
The relation of serum myeloperoxidase to disease progression and mortality in patients with chronic obstructive pulmonary disease (COPD). [PDF]
PLoS ONE, 2013 Myeloperoxidase is a strong oxidant stored in primary granules of neutrophils with potent antibacterial and proatherogenic properties. Myeloperoxidase has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD).
Hye Yun Park +6 more
doaj +1 more source
Научно-практическая ревматология, 2021 Aim of the work – to compare the frequency of upper respiratory tract (URT) involvement in patients with ANCAassociated vasculitides (AAV), to reveal its main clinical and radiological patterns and to estimate their association with the serological ...
I. G. Smirnova +4 more
doaj +1 more source
Myeloid expression of the anti-apoptotic protein Mcl1 is required in anti-myeloperoxidase vasculitis but myeloperoxidase inhibition is not protective [PDF]
, 2022 Antibodies to neutrophil and monocyte myeloperoxidase and proteinase 3 are a feature of anti-neutrophil cytoplasmic antibody vasculitis, a disease with significant morbidity for which new treatments are needed.
Adrian Freeman +11 more
core +1 more source
Antioxidants, 2022 Background: Myeloperoxidase (MPO) and advanced oxidation protein products, or AOPP (a type of MPO-derived chlorinated adducts), have been implicated in Parkinson´s disease (PD). Human MPO also show sex-based differences in PD.
Emilio Fernández-Espejo +5 more
doaj +1 more source