Results 31 to 40 of about 87,247 (298)
Myeloperoxidase G-463A and CYBA C242T genetic variants in gestational diabetes mellitus
Vascular Biology, 2023 Oxidative stress plays an important role in the pathophysiology of gestational diabetes mellitus (GDM). We investigated the relationship between NADPH oxidase p22phox subunit (CYBA) C242T (rs4673) and myeloperoxidase (MPO) G-463A (rs2333227) genetic ...
Chenyu Jiang +10 more
doaj +1 more source
Serum myeloperoxidase: a novel biomarker for evaluation of patients with acute coronary syndrome.
, 2009 Objectives Myeloperoxidase, an abundant leucocyte enzyme, is elevated in culprit lesions that have ruptured in patients with sudden cardiac injury. Multiple lines of evidence suggest an association between myeloperoxidase and inflammation and acute ...
Gururajan, P. +6 more
core +1 more source
Myeloperoxidase inhibition ameliorates plaque psoriasis in mice [PDF]
, 2021 Plaque psoriasis is a common inflammatory condition of the skin characterized by red, flaking lesions. Current therapies for plaque psoriasis target many facets of the autoimmune response, but there is an incomplete understanding of how oxidative damage ...
Neu, Savannah D. +11 more
core +1 more source
The Iraqi Journal of Veterinary Medicine, 2022 This study aimed to investigate the potential protective role of Bifidobacterium (B.) infantis in alleviating induced duodenal and colon inflammation associated with ulcerative colitis (UC).
Majida Al-Qayim +3 more
doaj +1 more source
Cells, 2022 Rapidly progressive crescentic glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies (ANCA-GN) is a major cause of renal failure. Current immunosuppressive therapies are associated with severe side effects, intensifying the need for ...
Domenico Cerullo +6 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Antioxidants, 2023 Extracellular traps are released by neutrophils and other immune cells as part of the innate immune response to combat pathogens. Neutrophil extracellular traps (NETs) consist of a mesh of DNA and histone proteins decorated with various anti-microbial ...
Line A. E. Hallberg +2 more
doaj +1 more source
Modification of the Method for Determining Myeloperoxidase in Blood Neutrophils [PDF]
, 2021 Myeloperoxidase is a heme-containing peroxidase expressed primarily in neutrophils and to a lesser extent in monocytes. Determining the activity of myeloperoxidase in blood cells is one of the tests of the immune status of animals.
E. Ageeva, Elizaveta +5 more
core +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Neutrophil NET Formation with Microbial Stimuli Requires Late Stage NADPH Oxidase Activity
Antioxidants, 2021 Neutrophils respond to a range of stimuli by releasing extracellular traps (NETs), a mesh consisting of chromatin plus granule and cytoplasmic proteins.
Heather A. Parker +4 more
doaj +1 more source