Results 31 to 40 of about 92,132 (290)

Myeloperoxidase G-463A and CYBA C242T genetic variants in gestational diabetes mellitus

Vascular Biology, 2023
Oxidative stress plays an important role in the pathophysiology of gestational diabetes mellitus (GDM). We investigated the relationship between NADPH oxidase p22phox subunit (CYBA) C242T (rs4673) and myeloperoxidase (MPO) G-463A (rs2333227) genetic ...
Chenyu Jiang, Mi Zhou, Huai Bai, Meng Chen, Chunyi Yang, Kaifeng Hu, Yujie Wu, Qingqing Liu, Yangyu Zhao, Xinghui Liu, Ping Fan   +10 more
doaj   +1 more source

Serum myeloperoxidase: a novel biomarker for evaluation of patients with acute coronary syndrome.

, 2009
Objectives Myeloperoxidase, an abundant leucocyte enzyme, is elevated in culprit lesions that have ruptured in patients with sudden cardiac injury. Multiple lines of evidence suggest an association between myeloperoxidase and inflammation and acute ...
Gururajan, P., Sarasabharati, A., Nayar, P., Babu, S., Victor, D., Cherian, K.M., Gurumurthy, P.   +6 more
core   +1 more source

Role of Bifidobacterium infantis in the Treatment of Duodenal and Colon Inflammation in Induced Ulcerative Colitis

The Iraqi Journal of Veterinary Medicine, 2022
This study aimed to investigate the potential protective role of Bifidobacterium (B.) infantis in alleviating ‎‎induced duodenal and colon inflammation associated with ulcerative colitis (UC).
Majida Al-Qayim, Ali Muhsin Al-Rudaini, Mehmet Sezgin, Inam Badr Falih   +3 more
doaj   +1 more source

Add-On Cyclic Angiotensin-(1-7) with Cyclophosphamide Arrests Progressive Kidney Disease in Rats with ANCA Associated Glomerulonephritis

Cells, 2022
Rapidly progressive crescentic glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies (ANCA-GN) is a major cause of renal failure. Current immunosuppressive therapies are associated with severe side effects, intensifying the need for ...
Domenico Cerullo, Daniela Rottoli, Daniela Corna, Mauro Abbate, Ariela Benigni, Giuseppe Remuzzi, Carlamaria Zoja   +6 more
doaj   +1 more source

Myeloperoxidase in human intracranial aneurysms: preliminary evidence

, 2015
BACKGROUND AND PURPOSE: Noninvasive imaging identifying a predictive biomarker of the bleeding risk of unruptured intracranial aneurysms (UIAs) is needed. We investigated a potential biomarker of UIA instability, myeloperoxidase, in human aneurysm tissue.
Vedantham, Srinivasan, Brooks, Christopher S., Bogdanov, Alexei A. Jr., Weaver, John P., Puri, Ajit S, Gounis, Matthew J, Wakhloo, Ajay K.   +6 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Antioxidant Strategies to Modulate NETosis and the Release of Neutrophil Extracellular Traps during Chronic Inflammation

Antioxidants, 2023
Extracellular traps are released by neutrophils and other immune cells as part of the innate immune response to combat pathogens. Neutrophil extracellular traps (NETs) consist of a mesh of DNA and histone proteins decorated with various anti-microbial ...
Line A. E. Hallberg, Kristine Barlous, Clare L. Hawkins   +2 more
doaj   +1 more source

Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodeling

, 2017
Rationale: Ventricular arrhythmias remain the leading cause of death in patients suffering myocardial ischemia. Myeloperoxidase, a heme enzyme released by polymorphonuclear neutrophils, accumulates within ischemic myocardium and has been linked to ...
Florian G. Deuschl, Hazen, Stanley L., Rudolph, Tanja K., Klinke, Anna, Kerkenpa, Christina, Gabriel Peinkofer, Mehrkens, Dennis, Dennis Mehrkens, Maass, Martina, Adam, Matti, Tang, W.H. Wilson, Volker Rudolph, Saric, Tomo, Wu, Yuping, Jan Gesenberg, Manchanda, Kashish, Anna Klinke, Lau, Denise, Johanna Schneider, Kai Friedrichs, Schneider, Johanna, Tomo Saric, Peinkofer, Gabriel, Stephan Baldus, Martin Mollenhauer, Deuschl, Florian G., Thomas Eschenhagen, Lisa Remane, W.H. Wilson Tang, Ravekes, Thorben, Martina Maass, Denise Lau, Tanja K. Rudolph, Eschenhagen, Thomas, Mollenhauer, Martin, Marcel Halbach, Kubala, Lukas, Matti Adam, Halbach, Marcel, Remane, Lisa, Jenny Krause, Rudolph, Volker, Christina Kerkenpaß, Lukas Kubala, Friedrichs, Kai, Thorben Ravekes, Krause, Jenny, Yuping Wu, Lange, Max, Baldus, Stephan, Stanley L. Hazen, Max Lange, Geertz, Birgit, Gesenberg, Jan, Birgit Geertz, Kashish Manchanda   +55 more
core   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source