Results 91 to 100 of about 4,338,055 (298)

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

RESISTANT HYPERTENSION IN CHRONIC RENAL FAILURE

The Iraqi Journal of Medical Sciences, 2016
Background:Several factors involved in the pathogenesis of hypertension among chronic renal failure patients including sodium and water retention, increased activity of vasoconstrictive systems, decrease activity of vasodilatory systems, increased ...
Jawad K. Manuti
doaj   +4 more sources

Contractile responses of urinary bladder in an experimental model of chronic renal failure

Biomolecules & Biomedicine, 2012
Chronic kidney disease is a public health problem with increasing prevalence caused by diabetes, hypertension and glomerulonephritis. Number of publications investigate the lower urinary tract dysfunction due to CKD is limited.
Hüseyin Biçer, Esat Korgali, Gökhan Gökçe, Semih Ayan, Şahin Yıldırım, E. Yener Gültekin   +5 more
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Progression of Chronic Renal Failure [PDF]

Archives of Internal Medicine, 2003
Chronic renal failure is characterized by a persistently abnormal glomerular filtration rate. The rate of progression varies substantially. Several morphologic features are prominent: fibrosis, loss of native renal cells, and infiltration by monocytes and/or macrophages.
openaire   +2 more sources

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Dual‐Responsive Hydrogels Integrate Bioelectrical Stimulation and Piezo‐Photocatalysis for Regenerative Treatment of Infected Wounds

Advanced Science, EarlyView.
A wireless, dual‐responsive hydrogel (PVA/(PVDF‐TrFE)/BiOClBr@PDA) is developed to promote efficient regeneration of infected wounds by integrating piezoelectric stimulation with piezo‐photocatalytic pathways. Under simultaneous light and ultrasonic stimulation, the hydrogel generates therapeutic electrical cues and reactive oxygen species, disrupting ...
Baoying Dai, Wenxuan Qie, Xiaoye Li, Jingben Zheng, Ao He, Heng Dong, Jiangjiang Yan, Hao Zhang, Ziheng Pan, Hang Yin, Chuyi Zhou, Rui Kong, Hao Wang, Binghan Dai, Yannan Xie, Zhiqun Lin   +15 more
wiley   +1 more source

Frequency-reduction strategy of roxadustat in patients undergoing peritoneal dialysis: a multi-center retrospective cohort study

Frontiers in Medicine
BackgroundAlthough dose reduction is the guideline-recommended tapering strategy for roxadustat to maintain target hemoglobin levels in peritoneal dialysis (PD) patients during the maintenance phase, reducing the administration frequency represents ...
Xi Mi, Xi Mi, Xi Mi, Xi Mi, Xi Mi, Guanying Lin, Guanying Lin, Guanying Lin, Guanying Lin, Guanying Lin, Yijing Fang, Yijing Fang, Yijing Fang, Yijing Fang, Yijing Fang, Lu Zhu, Yanhong Lin, Yanhong Lin, Yanhong Lin, Yanhong Lin, Yanhong Lin, Tingting Zhang, Tingting Zhang, Tingting Zhang, Tingting Zhang, Tingting Zhang, Xiaohong Zhong, Xiaohong Zhong, Xiaohong Zhong, Xiaohong Zhong, Xiaohong Zhong, Xiaoyan Su, Xiaoyan Su, Xianrui Dou, Jun Ai, Jun Ai, Jun Ai, Jun Ai, Jun Ai   +38 more
doaj   +1 more source

Being adolescent with chronic renal failure: a view through existential phenomenology

Escola Anna Nery, 2018
Objective: To understand adolescent's experiences with chronic renal failure disease, attended in a pubic teaching hospital at São Paulo state.
Marcela Astolphi de Souza, Luciana de Lione Melo   +1 more
doaj   +1 more source

Parasites and chronic renal failure.

Journal of renal injury prevention, 2014
Suppression of the human immune system results in an increase in susceptibility to infection by various infectious agents. Conditions such as AIDS, organ transplantation and chronic renal insufficiency (CRI) are the most important cause of insufficient immune response against infections.
Mohammadi Manesh, Reza, Hosseini Safa, Ahmad, Sharafi, Seyedeh Maryam, Jafari, Rasool, Bahadoran, Mehran, Yousefi, Morteza, Nasri, Hamid, Yousofi Darani, Hossein   +7 more
openaire   +2 more sources