Results 211 to 220 of about 1,166,644 (417)

Comparison of Hemodynamic Effects of Glucagon and Ketamine in Patients with Chronic Renal Failure [PDF]

open access: bronze, 1972
G. H. Hobika   +5 more
openalex   +1 more source

Solanidine‐derived CYP2D6 phenotyping elucidates phenoconversion in multimedicated geriatric patients

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Phenoconversion, a genotype‐phenotype mismatch, challenges a successful implementation of personalized medicine. The aim of this study was to detect and determine phenoconversion using the solanidine metabolites 3,4‐seco‐solanidine‐3,4‐dioic acid (SSDA) and 4‐OH‐solanidine as diet‐derived cytochrome P450 2D6 (CYP2D6) biomarkers in a ...
Jens Andreas Sarömba   +9 more
wiley   +1 more source

The effect of severe renal impairment on the pharmacokinetics, safety and tolerability of balcinrenone

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this phase 1 trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone (previously AZD9977) in participants with severe renal impairment vs. those with normal renal function. Methods Participants with severe renal impairment (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73 m2) not on dialysis were ...
Chandrali S. Bhattacharya   +10 more
wiley   +1 more source

Novel Approaches in Chronic Renal Failure without Renal Replacement Therapy: A Review. [PDF]

open access: yesBiomedicines, 2023
Martínez-Hernández SL   +4 more
europepmc   +1 more source

USE OF 1 ALPHA-HYDROXYVITAMIN D3 ON CHILDREN WITH CHRONIC RENAL FAILURE [PDF]

open access: bronze, 1974
James C.M. Chan   +4 more
openalex   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia   +4 more
wiley   +1 more source

Early Sympathetic Activation in the Initial Clinical Stages of Chronic Renal Failure

open access: yesHYPERTENSION, 2011
G. Grassi   +7 more
semanticscholar   +1 more source

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