Results 151 to 160 of about 435,562 (349)

Tumor Microenvironment‐Responsive Nanoreactor Induces Disulfidptosis in Pancreatic Cancer via Metabolic Interference and Redox Catalysis

Advanced Science, EarlyView.
Schematic illustration of a tumor microenvironment‐responsive nanoreactor for imaging‐guided induction of disulfidptosis in pancreatic cancer via metabolic interference and redox catalysis. (A) Stepwise fabrication of Pht@HMnO2‐HA, including MnO2 growth on a SiO2 template, template removal to form hollow mesoporous MnO2, Pht loading, and subsequent ...
Rui Fu, Qing Li, Guanzhong Zhao, Qingyan Gao, Huantong Chen, Khemayanto Hidayat, Jiaying Xu, Liqiang Qin, Chunhong Hu, Yu Chong, Su Hu   +10 more
wiley   +1 more source

Prevalence of chronic disease comorbidity among the elderly population in Jiangsu province, 2021: a cross-sectional survey

Zhongguo gonggong weisheng
ObjectiveTo investigate the prevalence of chronic disease comorbidity among the elderly population in Jiangsu province to provide evidence for the development of chronic disease management strategies.
Weihao WANG, Dakang JI, Chenghao XUE, Haijian GUO, jinshui XU, Yuxuan WU, Rouzi Zulipikaer, Bei WANG   +7 more
doaj   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Baseline characteristics of the Chronic Renal Insufficiency Cohort study Analytic sample.

, 2018
Baseline characteristics of the Chronic Renal Insufficiency Cohort study Analytic sample.
Meda E. Pavkov (3154854), Sundar S. Shrestha (3143406), Dawei Xie (5873771), Thomas J. Hoerger (3154857), Amanda H. Anderson (5873768), Hsiang-Yu Chen (2321644), Benjamin O. Yarnoff (3154848), Siobhan K. Simpson (5873765), Nilka R. Burrows (3154863)   +8 more
core   +1 more source

Effect of Lactulose on the Intestinal Flora of Elderly Constipation Patients With Chronic Renal Insufficiency

AGING MEDICINE, EarlyView.
This study investigates the regulatory effects of lactulose and polyethylene glycol (PEG) on the composition of gut microbiota in elderly constipation patients with chronic renal insufficiency by comparing the changes in microbial abundance. Both lactulose and PEG significantly modulate the gut microbiota structure, though their specific mechanisms and
Jianxia Ma, Jun Wang, Tianran Han, Zhifang Shao, Weiqi Zhang, Ke Wang, Qinlian Zeng, Kangwei Liu, Yuanwen Chen, Songbai Zhen, Jianfeng Yao   +10 more
wiley   +1 more source

Urinary Peptide Levels in Patients with Chronic Renal Failure

, 2010
Introduction: Peptide levels in urine are found to be decreased in renal failure. In the current study urinary peptide levels were determined in chronic renal failure (CRF) patients.
Supriya M, Phani, Nagaraj M, M, Supriya, Nagaraj M Phani, Kavya R, Mungli, Prakash, R, Kavya, Mungli Prakash   +7 more
core  

Biomarkers of Sarcopenia: Current Status and Future Perspectives

AGING MEDICINE, EarlyView.
In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo, Wenhan Li, Yi Zhang, Mengchen Liu, Kemeng Zhang, Sui Huang, Ping He   +6 more
wiley   +1 more source

Chronic renal insufficiency can cause early anemia: A cross-sectional study

National Journal of Physiology, Pharmacy and Pharmacology
Background: Chronic renal insufficiency has emerged as a global health issue, causing significant morbidity and mortality. Anybody can develop anemia but it is very common in people with chronic kidney disease (CKD).
Ravi Kishore Reddy Vintha, Mohammad Amzarul, Ausaf Ahmad, Sara Siddiqui   +3 more
doaj   +1 more source

Creatinine clearance versus serum creatinine as a risk factor in cardiac surgery

, 2003
Walter JA, Mortasawi A, Arnrich B, et al. Creatinine clearance versus serum creatinine as a risk factor in cardiac surgery. BMC Surgery. 2003;3(1): 4.BACKGROUND: Renal impairment is one of the predictors of mortality in cardiac surgery.
Mortasawi, Amir, Inez Frerichs, Albert, Alexander, Mortasawi Amir, Rosendahl Ulrich, Frerichs, Inez, Alexander Albert, Ulrich Rosendahl, Jürgen Ennker, Amir Mortasawi, Walter, Jörg, Arnrich, Bert, Rosendahl, Ulrich, Frerichs Inez, Albert Alexander, Arnrich Bert, Ennker Jürgen, Jörg Walter, Bert Arnrich, Walter, Jörg A., Walter Jörg, Ennker, Jürgen   +21 more
core   +1 more source

“Intrapericardial Approach” for Venous Outflow Reconstruction in Living‐Donor Liver Transplantation for Budd‐Chiari Syndrome: Surgical Techniques and LongTerm Outcomes

Annals of Gastroenterological Surgery, EarlyView.
Unlike deceased‐donor liver transplantation, living‐donor liver transplantation (LDLT) for Budd‐Chiari Syndrome (BCS) presents distinctive challenges in hepatic venous (HV)‐outflow reconstruction because diseased HV–inferior vena cava (IVC) cannot be entirely replaced with healthy donor vessels.
Koichiro Hata, Tetsuya Tajima, Satoshi Ogiso, Shinji Uemoto, Etsuro Hatano   +4 more
wiley   +1 more source