Results 201 to 210 of about 4,199,988 (295)

The importance of advance care planning for children with chronic respiratory failure. [PDF]

Pediatr Pulmonol, 2020
Miles AH, Turnbull AE, Sterni LM.
europepmc   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Long Term Therapy of Chronic Heart Failure

Chronic Heart Failure (CHF), also known as Congestive Heart Failure, remains a major global health burden, requiring a thorough understanding of its complex pathophysiology and treatment.
Akmal, Mustafa Ahmed
core  

Does PaCO₂ correction have an impact on survival of patients with chronic respiratory failure and long-term non-invasive ventilation? [PDF]

Heliyon
Thomas A, Jaffré S, Guardiolle V, Perennec T, Gagnadoux F, Goupil F, Bretonnière C, Danielo V, Morin J, Blanc FX.   +9 more
europepmc   +1 more source

Acute/Chronic respiratory failure

Intensive Care Medicine, 1992
De La Cruz, C., Criado, A., Diaz, L., Seiz, A., Vidaur, P. L., Fraile, J. R., Filos, K. S., Goudas, L. C., Dougenis, D., Tassoudis, V., Patroni, O., Winkler, W. -B., Karnik, R., Seelmann, O., Havlicek, J., Stany, J., Becker, H., Peter, J. H., Pitzer, W., Schneider, H., Wichert, P. V., De Blasi, R. A., Conti, G., Mattia, C., Mega, A. M., Ferrari, M., Gasparetto, A., Steltzer, H., Hiesmayr, M., Krafft, P., Petcold, R., Strasser, K., Hammerle, A. F., Capellier, G., Liauw, S., Wintoh, T., Marshall, J., Demajo, W., Barale, F., Walker, P. M., Dugernier, T., Laterre, P. F., Deby-Dupont, G., Lamy, M., Reynaert, M. S., Navarrete, P., Vázquez, G., Rivera, R., Fernandez, E., Mérida, A., Boch, J. N., Eibenberger, K., Herold, C., Schlick, W., van der Heijde, R. M. J. L., Grotjohan, H. P., Versprille, A., Wagenvoort, C. A., Raijmakers, P. G. H. M., Groeneveld, A. B. J., Schneider, A. J., Rauwerda, J. A., Teule, G. J. J., Thija, L. G., Singer, M., Vermaat, J., Hall, G., Latter, G., Patel, M., Jansen, J. R. C., Bordet, F., Mercatello, A., Coronel, B., Bret, M., Tlgaud, J. D., Archimbaud, E., Moskovtchenko, J. F., Gregorakos, L., Katsanos, Ch., Michalopoulos, A., Malessios, V., Mavropanou, D., Nicolopoulos, J., Karageorgiou, K., Tognet, E., Polo, P., Devaux, Y., Fière, D., Valta, P., Takala, J., De Blasio, F., Iannuzzi, E., De Sio, A., Ferraro, F., Schiraldi, F., Mostarda, G. F., Spannbrucker, N., Kiesow, U., Kleinschmidt, R., Reper, P., Marion, E., Van Hille, F., De Neef, H., Heymans, W., Ysebaert, D., Van Hoof, R., Vanderkelen, A., Elsen, M., Gregoretti, C., Beltrame, F., Conti, G., Burbi, L., Antonaglia, V., Lucangelo, U., Biolino, P., Giugiaro, P. M., Sasso, F., Schneider, H., Becker, H., Cassel, W., Peter, J. H., von Wichert, P., Ludwigs, Ulf, Klingstedt, Christer, Baehrendtz, Svante, Hedenstierna, Göran, Gomez, V., De la Casa, R., Anon, J. M., Pascual, C., Jimenez, M., Yus, S., Angouridakis, P., Sofianos, B., Anastasaki, M., Frantzeskos, G., Askitopoelou, B., Priem, R., Schultheiss, R., Cedzich, C., Rabbat, A., Garrouste, M. T., Nahmias, G., Le Gall, J. R., Schlemmer, B., Wegenius, Göran, Matte, P., Jacquet, L., Ceriani, R., Goenen, M., Roeseler, J., Palavecino, L., Dougnac, A., Reynaert, H., Avila, A., Oliphant, L., Ward, C., Spitzer, Sh., Fink, G., Putensen, C., Leon, M., Putensen-Himmer, G.   +161 more
openaire   +2 more sources

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Predicting Single‐Cell Perturbation Responses Across Biological Contexts With a Deep Generative Model Integrating Optimal Transport

Advanced Science, EarlyView.
Single‐cell perturbation responses are predicted across held‐out biological contexts using scPILOT, a query‐conditioned two‐stage latent response‐transfer framework. A shared latent representation supports cell‐level response estimation by latent optimal transport, followed by Leiden‐localized query‐specific transfer and adaptive weighting.
Jialiang Wang, Ziqi Liu, Zhengqian Zhang, Yikun Cao, Junjun Ren, Peng Cheng, Jingjing Tian, Lingyun Xie, Xin Lu, Zhanwei Du, Yongzhuang Liu   +10 more
wiley   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source