Results 201 to 210 of about 3,573,775 (294)
Long Term Therapy of Chronic Heart Failure
Chronic Heart Failure (CHF), also known as Congestive Heart Failure, remains a major global health burden, requiring a thorough understanding of its complex pathophysiology and treatment.Akmal, Mustafa Ahmedcore Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model
Advanced Science, EarlyView.Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen +16 morewiley +1 more sourceDual‐Functional Silent‐Region SERS Nanoplatform for Real‐Time Bacterial Tracking and Wound Healing Therapy
Advanced Science, EarlyView.ABSTRACT
Bacterial wound infections, particularly those caused by Escherichia coli and Pseudomonas aeruginosa, are difficult to treat due to biofilm formation, multidrug resistance, and chronic inflammation. Here, we report a multifunctional nanoplatform based on a surface‐enhanced Raman scattering (SERS) probe that enables simultaneous photodynamic ...Hanbin Deng, Rui Wang, Dianqi Zhang, Wei Zhang, Jaebum Choo, Fabiao Yu, Shaowen Cheng +6 morewiley +1 more sourceA Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions
Advanced Science, EarlyView.An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao +15 morewiley +1 more sourcePEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation
Advanced Science, EarlyView.This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You +15 morewiley +1 more sourceAn Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance
Advanced Science, EarlyView.A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren +11 morewiley +1 more sourceAcute/Chronic respiratory failure
Intensive Care Medicine, 1992 De La Cruz, C., Criado, A., Diaz, L., Seiz, A., Vidaur, P. L., Fraile, J. R., Filos, K. S., Goudas, L. C., Dougenis, D., Tassoudis, V., Patroni, O., Winkler, W. -B., Karnik, R., Seelmann, O., Havlicek, J., Stany, J., Becker, H., Peter, J. H., Pitzer, W., Schneider, H., Wichert, P. V., De Blasi, R. A., Conti, G., Mattia, C., Mega, A. M., Ferrari, M., Gasparetto, A., Steltzer, H., Hiesmayr, M., Krafft, P., Petcold, R., Strasser, K., Hammerle, A. F., Capellier, G., Liauw, S., Wintoh, T., Marshall, J., Demajo, W., Barale, F., Walker, P. M., Dugernier, T., Laterre, P. F., Deby-Dupont, G., Lamy, M., Reynaert, M. S., Navarrete, P., Vázquez, G., Rivera, R., Fernandez, E., Mérida, A., Boch, J. N., Eibenberger, K., Herold, C., Schlick, W., van der Heijde, R. M. J. L., Grotjohan, H. P., Versprille, A., Wagenvoort, C. A., Raijmakers, P. G. H. M., Groeneveld, A. B. J., Schneider, A. J., Rauwerda, J. A., Teule, G. J. J., Thija, L. G., Singer, M., Vermaat, J., Hall, G., Latter, G., Patel, M., Jansen, J. R. C., Bordet, F., Mercatello, A., Coronel, B., Bret, M., Tlgaud, J. D., Archimbaud, E., Moskovtchenko, J. F., Gregorakos, L., Katsanos, Ch., Michalopoulos, A., Malessios, V., Mavropanou, D., Nicolopoulos, J., Karageorgiou, K., Tognet, E., Polo, P., Devaux, Y., Fière, D., Valta, P., Takala, J., De Blasio, F., Iannuzzi, E., De Sio, A., Ferraro, F., Schiraldi, F., Mostarda, G. F., Spannbrucker, N., Kiesow, U., Kleinschmidt, R., Reper, P., Marion, E., Van Hille, F., De Neef, H., Heymans, W., Ysebaert, D., Van Hoof, R., Vanderkelen, A., Elsen, M., Gregoretti, C., Beltrame, F., Conti, G., Burbi, L., Antonaglia, V., Lucangelo, U., Biolino, P., Giugiaro, P. M., Sasso, F., Schneider, H., Becker, H., Cassel, W., Peter, J. H., von Wichert, P., Ludwigs, Ulf, Klingstedt, Christer, Baehrendtz, Svante, Hedenstierna, Göran, Gomez, V., De la Casa, R., Anon, J. M., Pascual, C., Jimenez, M., Yus, S., Angouridakis, P., Sofianos, B., Anastasaki, M., Frantzeskos, G., Askitopoelou, B., Priem, R., Schultheiss, R., Cedzich, C., Rabbat, A., Garrouste, M. T., Nahmias, G., Le Gall, J. R., Schlemmer, B., Wegenius, Göran, Matte, P., Jacquet, L., Ceriani, R., Goenen, M., Roeseler, J., Palavecino, L., Dougnac, A., Reynaert, H., Avila, A., Oliphant, L., Ward, C., Spitzer, Sh., Fink, G., Putensen, C., Leon, M., Putensen-Himmer, G. +161 moreopenaire +2 more sourcesA Dual‐Modal Wearable PPG Smartwatch with AI‐Enhanced Correction for High‐Accuracy and Continuous AF Burden Assessment
Advanced Science, EarlyView.ABSTRACT
Atrial fibrillation (AF) increases the risk of stroke and heart failure, yet accurate quantification of AF burden in daily life remains difficult. Although smartwatch photoplethysmography (PPG) supports continuous monitoring, complex rhythms and signal noise can impair burden estimation.Song Zuo, Jinglei Wang, Xin Wang, Han Feng, Yize Zhao, Fadong Li, Shaobin Wei, Le Zhou, Zixu Zhao, Songjie Chen, Xiangyi Kong, Jue Wang, Liu He, Shijun Xia, Xin Li, Junmeng Zhang, Xiaoxia Liu, Xueyuan Guo, Ning Zhou, Songnan Li, Chenxi Jiang, Ribo Tang, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Wenwu Zhu, Changsheng Ma +27 morewiley +1 more source
