Results 51 to 60 of about 4,487,488 (290)

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Association of Low body Mass Index with Respiratory Failure in Chronic Obstructive Pulmunary Disease

Journal of Nepal Health Research Council, 2021
Background: Various studies have shown that low body mass index co-relates with the severity of Chronic obstructive pulmonary disease. The reduced body mass index in these patients is thought to be due to nutritional abnormality and raised circulating ...
Ritamvara Oli, Jai Krishna Mishra, Govind Narayan Srivastava, Saurabh Mishra   +3 more
doaj   +1 more source

Systems for the management of respiratory disease in primary care - an international series: United Kingdom [PDF]

, 2010
INTRODUCTION: The UK National Health Service (NHS) is essentially publicly funded through general taxation. Challenges facing the NHS include the rise in prevalence of long-term conditions and financial pressures.
Allison Worth, Mark Levy, Worth, Allison, Levy, Mark L., Fletcher, Monica, Pinnock, Hilary, Aziz Sheikh, Monica Fletcher, Hilary Pinnock, Pinnock, Hilary; id_orcid, Hoskins, Gaylor, Levy, Mark, Gaylor Hoskins, Sheikh, Aziz, Levy, Mark L   +14 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Respiratory failure

, 2019
Respiratory failure is a common complication of acute cardiorespiratory disease and exacerbations of chronic respiratory disease. It can be a feature of advanced chronic cardiac, respiratory and neurological diseases.
Creagh-Brown, Ben
core   +1 more source

ERS Clinical Practice Guidelines: high-flow nasal cannula in acute respiratory failure. [PDF]

, 2021
BACKGROUND High-flow nasal cannula (HFNC) has become a frequently used non-invasive form of respiratory support in acute settings, however evidence supporting its use has only recently emerged.
Heunks, Leo, Thille, Arnaud W, Ferrer, Miguel, Ergan, Begüm, Navalesi, Paolo, Chatwin, Michelle, Tonia, Thomy, Longhini, Federico, Scala, Raffaele, Sotgiu, Giovanni, Frat, Jean-Pierre, Pisani, Lara, Winck, João Carlos, Oczkowski, Simon, Renda, Teresa, Nava, Stefano, Bos, Lieuwe, Gregoretti, Cesare, Windisch, Wolfram, Boyd, Jeanette, Uğurlu, Aylin Ozsancak, Ozsancak Uğurlu, Aylin, Teresa Renda, Wolfram Windisch, Arnaud W. Thille, Jean-Pierre Frat, Michelle Chatwin, Leo Heunks, Federico Longhini, Stefano Nava, Paolo Navalesi, Begüm Ergan, João Carlos Winck, Thomy Tonia, Cesare Gregoretti, Miguel Ferrer, Raffaele Scala, Simon Oczkowski, Lara Pisani, Jeanette Boyd, Giovanni Sotgiu, Aylin Ozsancak Uğurlu, Lieuwe Bos   +42 more
core   +3 more sources

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Computed Tomography Images of Fibrotic Pulmonary Sarcoidosis Leading to Chronic Respiratory Failure

, 2020
Background: There is currently no consensus on the morphology of severe fibrotic pulmonary sarcoidosis, and we examined computed tomography (CT) findings and progression.
Takeshi Kawanobe, Noriharu Shijubo, Tamiko Takemura, Takeshi Johkoh, Michiru Sawahata, Masashi Bando, Koichi Hagiwara, Tetsuo Yamaguchi, Fumikazu Sakai, Chiyoko Kono, Satoshi Konno, Yosikazu Nakamura   +11 more
core   +1 more source