Results 221 to 230 of about 620,869 (306)

A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside

Advanced Science, EarlyView.
(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin, Zijian Yan, Jiayi Chen, Xiaochao Wang, Ruibin Lin, Yunqi Fu, Zhaoying Lv, Bohui Wu, Xuewei Cao, Renjian Xie, Ming Dong, Chenxiao Zheng, Li Ren   +12 more
wiley   +1 more source

Smartly Assembled near‐Micron RF‐Responsive Agents Bridge Transarterial Embolization and Immunothermal Potentiation

Advanced Science, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) remains a significant clinical challenge due to the limited efficacy of conventional treatments like surgery, radiofrequency ablation (RFA), and transarterial embolization (TAE). Here, we develop an innovative TAE and immunothermal therapy strategy based on smartly assembled near‐micron layered double hydroxide ...
Qitao Hu, Junkang Ding, Lingxiao Zhang, Zhou Tian, Cheng Zeng, Shaomin Zou, Wenjing Zhang, Tangye Zeng, Zhencang Gao, Zhouyi Sun, Gang Liu, Weiyu Chen, Zhe Tang   +12 more
wiley   +1 more source

Artificial Piezoelectric Interface Enables Ultrafast Interfacial Ion Kinetic for Highly‐Sensitive Piezoionic Sensors

Advanced Science, EarlyView.
This study proposes a piezoelectric interface modification strategy to amplify the piezoionic effect. The piezoelectric interface generates an intrinsic electric field, which not only drives rapid ion migration but also concentrates polarized ions on the interface. The flexible sensor delivers superior performance, such as a quick response rate, strong
Yanyu Chen, Xingyue Ling, Rizhong Gao, Xiaohong Zhang, Xi Chen, Chao Lu   +5 more
wiley   +1 more source

[Chronic respiratory failure].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1991
openaire   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Internet of things-based management versus standard management of home noninvasive ventilation in COPD patients with hypercapnic chronic respiratory failure: a multicentre randomized controlled non-inferiority trial. [PDF]

EClinicalMedicine
Jiang W, Jin X, Du C, Gu W, Gao X, Zhou C, Tu C, Chen H, Li H, Shen Y, Zhang Y, Ge X, Sun Y, Zhou L, Yu S, Zhao K, Cheng Q, Zhu X, Liao H, Bai C, Song Y.   +20 more
europepmc   +1 more source

Acute/Chronic respiratory failure

Intensive Care Medicine, 1992
De La Cruz, C., Criado, A., Diaz, L., Seiz, A., Vidaur, P. L., Fraile, J. R., Filos, K. S., Goudas, L. C., Dougenis, D., Tassoudis, V., Patroni, O., Winkler, W. -B., Karnik, R., Seelmann, O., Havlicek, J., Stany, J., Becker, H., Peter, J. H., Pitzer, W., Schneider, H., Wichert, P. V., De Blasi, R. A., Conti, G., Mattia, C., Mega, A. M., Ferrari, M., Gasparetto, A., Steltzer, H., Hiesmayr, M., Krafft, P., Petcold, R., Strasser, K., Hammerle, A. F., Capellier, G., Liauw, S., Wintoh, T., Marshall, J., Demajo, W., Barale, F., Walker, P. M., Dugernier, T., Laterre, P. F., Deby-Dupont, G., Lamy, M., Reynaert, M. S., Navarrete, P., Vázquez, G., Rivera, R., Fernandez, E., Mérida, A., Boch, J. N., Eibenberger, K., Herold, C., Schlick, W., van der Heijde, R. M. J. L., Grotjohan, H. P., Versprille, A., Wagenvoort, C. A., Raijmakers, P. G. H. M., Groeneveld, A. B. J., Schneider, A. J., Rauwerda, J. A., Teule, G. J. J., Thija, L. G., Singer, M., Vermaat, J., Hall, G., Latter, G., Patel, M., Jansen, J. R. C., Bordet, F., Mercatello, A., Coronel, B., Bret, M., Tlgaud, J. D., Archimbaud, E., Moskovtchenko, J. F., Gregorakos, L., Katsanos, Ch., Michalopoulos, A., Malessios, V., Mavropanou, D., Nicolopoulos, J., Karageorgiou, K., Tognet, E., Polo, P., Devaux, Y., Fière, D., Valta, P., Takala, J., De Blasio, F., Iannuzzi, E., De Sio, A., Ferraro, F., Schiraldi, F., Mostarda, G. F., Spannbrucker, N., Kiesow, U., Kleinschmidt, R., Reper, P., Marion, E., Van Hille, F., De Neef, H., Heymans, W., Ysebaert, D., Van Hoof, R., Vanderkelen, A., Elsen, M., Gregoretti, C., Beltrame, F., Conti, G., Burbi, L., Antonaglia, V., Lucangelo, U., Biolino, P., Giugiaro, P. M., Sasso, F., Schneider, H., Becker, H., Cassel, W., Peter, J. H., von Wichert, P., Ludwigs, Ulf, Klingstedt, Christer, Baehrendtz, Svante, Hedenstierna, Göran, Gomez, V., De la Casa, R., Anon, J. M., Pascual, C., Jimenez, M., Yus, S., Angouridakis, P., Sofianos, B., Anastasaki, M., Frantzeskos, G., Askitopoelou, B., Priem, R., Schultheiss, R., Cedzich, C., Rabbat, A., Garrouste, M. T., Nahmias, G., Le Gall, J. R., Schlemmer, B., Wegenius, Göran, Matte, P., Jacquet, L., Ceriani, R., Goenen, M., Roeseler, J., Palavecino, L., Dougnac, A., Reynaert, H., Avila, A., Oliphant, L., Ward, C., Spitzer, Sh., Fink, G., Putensen, C., Leon, M., Putensen-Himmer, G.   +161 more
openaire   +2 more sources

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Wireless, Adaptable and Fully Implantable Battery‐powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents

Advanced Science, EarlyView.
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh, Adan Moallemi, Elham Mohseni Vadeghani, Samuel Tretjakov, Brianna Tsuyuki, Alexander Golab, Benjamin Rever, Wolfram Tetzlaff, Dena Shahriari   +8 more
wiley   +1 more source