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T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Respiratory muscle function in chronic respiratory failure.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, 1994 openaire +1 more source
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2020
Abstract Chronic respiratory failure describes a clinical state when the arterial Po2 breathing air is less than 8.0 kPa, which may or may not be associated with hypercapnia (defined as Pco2 more than 6.0 kPa (45 mm Hg)). Four processes cause arterial hypoxaemia due to inefficient pulmonary gas exchange—ventilation–perfusion (V/Q ...
Michael I. Polkey, P.M.A. Calverley
openaire +1 more source
Abstract Chronic respiratory failure describes a clinical state when the arterial Po2 breathing air is less than 8.0 kPa, which may or may not be associated with hypercapnia (defined as Pco2 more than 6.0 kPa (45 mm Hg)). Four processes cause arterial hypoxaemia due to inefficient pulmonary gas exchange—ventilation–perfusion (V/Q ...
Michael I. Polkey, P.M.A. Calverley
openaire +1 more source
Chronic respiratory failure in bronchopulmonary dysplasia
Pediatric Pulmonology, 2021AbstractAlthough survival has improved dramatically for extremely preterm infants, those with the most severe forms of bronchopulmonary dysplasia (BPD) fail to improve in the neonatal period and go on to develop chronic respiratory failure. When careful weaning of respiratory support is not tolerated, the difficult decision of whether or not to pursue ...
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Acute and chronic respiratory failure
2014Respiratory failure (RF) can be attributed to a plethora of neuromuscular diseases (NMDs) and manifests clinically in a multitude of overt or more subtle ways. The basic principles of pathophysiology, diagnosis and treatment of neurologic diseases and of RF apply concomitantly to this subset of patients.
Sabin, Oana, Jayanta, Mukherji
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2010
Chronic respiratory failure describes a clinical state when the arterial P o 2 breathing air is less than 8.0 kPa, which may or may not be associated with hypercapnia (defined as P co 2 more than 6.0 kPa (45 mmHg)).
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Chronic respiratory failure describes a clinical state when the arterial P o 2 breathing air is less than 8.0 kPa, which may or may not be associated with hypercapnia (defined as P co 2 more than 6.0 kPa (45 mmHg)).
openaire +2 more sources
Chronic respiratory failure – pathophysiology
2020Respiratory failure is a condition in which the respiratory system fails in one or both of its gas-exchanging functions – oxygenation and carbon dioxide elimination. Although the causes of respiratory failure are diverse, they share common underlying mechanisms and management strategies for diagnosis and treatment.
Mafalda Vanzeller +2 more
openaire +1 more source
Chronic Respiratory Failure and Neuromuscular Disease
Pediatric Clinics of North America, 2009The outlook for children with respiratory complications of neuromuscular disease has improved significantly in the past 15 years. This has been the result of many advances in clinical care, including improved monitoring of lung function and hypoventilation during sleep; coordinated respiratory care by experienced physicians with access to specialized ...
Kennedy, J., Martin, A.
openaire +3 more sources